Which is better for 3D rendering and video encoding?

The 7980X. Its 64 cores and 128 threads finish multi-threaded renders and encodes faster than the 32-core 9975WX, even though the PRO chip has newer Zen 5 cores.

Which is better for CAD and single-threaded work?

The 9975WX. Zen 5 cores boost to 5.4 GHz versus 5.1 GHz on the 7980X, so per-core tasks like modeling and simulation setup run faster.

Do they use the same motherboard?

Both are sTR5, but the PRO chip is meant for PRO workstation boards with 8-channel RDIMM memory. Check your board's memory and lane support before swapping.

Which supports more memory?

The 9975WX, up to 2TB of ECC RDIMM DDR5 at up to 6400 MT/s. The 7980X tops out at 256GB of quad-channel DDR5 at 5200 MHz.

Is the 9975WX worth it over the 7980X?

Only if you need more than 256GB of memory, many PCIe 5.0 lanes, or faster per-core speed. If raw core count drives your workload, the 7980X does more work per dollar.

AMD Ryzen Threadripper 7980X vs AMD Ryzen Threadripper PRO 9975WX

Buy the Threadripper 7980X if you need maximum multi-core throughput: 64 cores and 128 threads beat the 9975WX's 32 cores and 64 threads for rendering, simulation and code builds. Buy the Threadripper PRO 9975WX if you need huge memory and newer architecture: it supports up to 2TB of RDIMM DDR5 at up to 6400 MT/s, has 8-channel memory, 128 PCIe 5.0 lanes and Zen 5 cores that boost to 5.4 GHz. Both are sTR5 and 350 W, so the platform cost is similar; the choice comes down to core count versus memory capacity and per-core speed.

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