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YOUTHFUL Quattro Peptide Face & Eye Serum vs SkinMedica Retinol Complex 0.5

Buy the YOUTHFUL Quattro Peptide if you want a gentle peptide serum you can use twice a day on face, eyes, neck and décolleté, including if your skin is sensitive or retinol has irritated you before. Buy the SkinMedica Retinol Complex if you already tolerate retinoids and want a stronger collagen and cell-turnover treatment for texture and coarse wrinkles. The YOUTHFUL is the easier daily product and covers more areas; the SkinMedica does more for texture but needs a slow start, twice-weekly use and daily SPF.

  • Choose the YOUTHFUL Quattro Peptide if you want a hydrating peptide serum for face and eyes that suits sensitive skin and can be used morning and night.
  • Choose the SkinMedica Retinol Complex if your skin is already used to retinol and you want a stronger treatment for texture, tone and coarse wrinkles.

Prices

  • YOUTHFUL Quattro Peptide Face & Eye Serum: $45.00 at Urban Waxx (checked today)
  • SkinMedica Retinol Complex 0.5: $64.00 at Dermstore.com (last seen Nov 8)
  • Difference: the YOUTHFUL Quattro Peptide Face & Eye Serum is $19.00 cheaper than the SkinMedica Retinol Complex 0.5 at the latest prices (Nov 8 and Nov 9)
YOUTHFUL
YOUTHFUL Quattro Peptide Face & Eye Serum

YOUTHFUL Quattro Peptide Face & Eye Serum

4.9(857 ratings)
$45.00at Urban WaxxVerified
See all prices and details
Visit Urban Waxx
Pros
  • Twice-daily use on face, eyes, neck and décolleté
  • Peptide and hyaluronic acid formula suits sensitive skin
  • No retinol irritation or purge phase
  • Owners report hydration by the next morning and lighter under-eyes
  • Free of PEGs and silicones
Cons
  • Small 0.5 oz bottle
  • No retinol, so slower on coarse wrinkles and texture
  • Overnight use not listed
  • Not marketed for men or kids
SkinMedica
SkinMedica Retinol Complex

SkinMedica Retinol Complex 0.5

SkinMedica Retinol Complex

4.8(350 ratings)
$64.00at Dermstore.comObserved Nov 8, 2026, 6:16 PM
See all prices and details
Visit Dermstore.com
Pros
  • Retinol is a well-studied collagen and cell-turnover ingredient
  • PhytoShield complex aims to cut irritation
  • 1 fl. oz. size
  • Owners rate it highly for texture and tone
Cons
  • Requires a retinol-tolerant skin and a gradual start
  • Twice-weekly use at first, so slower to build up
  • Daily SPF 30 or higher is required
  • Face only, not eyes or neck

What separates them

YOUTHFUL Quattro Peptide Face & Eye SerumSkinMedica Retinol Complex 0.5
Active approach20% quattro-peptide complex plus LSR10 and hyaluronic acid; no retinolRetinol as the main active, with PhytoShield antioxidant complex
Use frequencyDaily, morning and nightTwice a week to start, building tolerance
Application areaFace, eyes, neck and décolletéFace
Skin type fitAll skin types, including sensitive skinAll skin types, but only pre-conditioned by a lower-strength retinoid
Sun care neededNo special sun routine statedSPF 30 or higher required during use
Main benefitFirmness, elasticity and fine lines around eyes and mouthTexture, tone, radiance and coarse wrinkles via cell renewal
Size0.5 oz1 fl. oz.
Free ofPEGs and siliconesNot stated

Price history

$64.00$38.00
Oct 29Nov 9
  • YOUTHFUL Quattro Peptide Face & Eye Serum: lowest $38.00 on Nov 9.
  • SkinMedica Retinol Complex 0.5: lowest $64.00 on Nov 8 at Bluemercury.

Prices at every store

YOUTHFUL Quattro Peptide Face & Eye Serum

  • Urban WaxxNew

    In stockReturn policy

    $45.00Verified
    Visit Urban Waxx
  • EVER SkincareNew

    In stockReturn policy

    $94.00Verified
    Visit EVER Skincare

Also available at

  • AmazonCheck price at Amazon
  • eBayCheck price at eBay
  • EVERCheck price at EVER

Store links may earn us a commission.

All 2 stores and price history →

SkinMedica Retinol Complex 0.5

  • Dermstore.comNew

    In stock

    $64.00Free shippingObserved Nov 8, 2026, 6:16 PM
    Visit Dermstore.com
  • BluemercuryNew

    In stock

    $64.00+ $7.00 shippingObserved Nov 8, 2026, 6:15 PM
    Visit Bluemercury
  • LovelySkin.comNew

    In stock

    $72.00Free shippingObserved Nov 8, 2026, 6:16 PM
    Visit LovelySkin.com
  • BluemercuryNew

    In stock

    $64.00+ $9.95 shippingObserved Nov 8, 2026, 6:16 PM
    Visit Bluemercury

Store links may earn us a commission. Some prices via Klarna.

All 9 stores and price history →

Specs compared

SpecYOUTHFUL Quattro Peptide Face & Eye SerumSkinMedica Retinol Complex 0.5
Key IngredientPeptide, Hyaluronic AcidRetinol
Size0.5 oz1 fl. oz.
Body PartEyes, Face, Neck, décolleté—
FormSerum—
Skin ConcernsLines and wrinkles—
Skin TypeAll skin types—
Active IngredientsPeptide—
ContainsPeptide, Hyaluronic Acid—
Free OfPEGs, Silicones—
SubtypeHydrating serum—
TypeSerum—
Face Treatment TypeSerum—
Show all 30 specsShow fewer specs
SpecYOUTHFUL Quattro Peptide Face & Eye SerumSkinMedica Retinol Complex 0.5
For BabiesNo—
For KidsNo—
For MenNo—
EffectAnti-aging—
Application TimeDaily—
Application MethodApply—
Night / Day UseBoth—
Tattoo CareNo—
Overnight UseNo—
Use HighlightsUnder Eye

What reviewers say

YOUTHFUL Quattro Peptide Face & Eye Serum

  • 4.9 / 5857 ratings

Rated 4.9 out of 5 from 857 ratings, buyers describe skin that looks rejuvenated and hydrated by the next morning. They praise the subtle scent, the under-eye results and tolerance for sensitive skin without retinol side effects.

What people mention
  • HydrationPraisedBuyers say skin feels hydrated and looks rejuvenated by the next morning.
  • Under-eye resultsPraisedReviewers report the under-eye area looks lighter and younger.
  • Sensitive skinPraisedOwners with sensitive skin say it addresses aging concerns without irritation.
  • ScentPraisedThe scent is described as lovely and subtle.

SkinMedica Retinol Complex 0.5

  • 4.8 / 5350 ratings

Rated 4.8 out of 5 across 350 ratings, it draws praise for smoothing texture and softening fine lines without heavy irritation. Most negative comments center on sensitivity during the adjustment period and the cost of keeping up with it.

What people mention
  • IrritationMixedSome users report flaking, redness or stinging when they start or use it too often.
  • TexturePraisedReviewers say skin feels smoother and looks more even after several weeks.
  • Fine linesPraisedMany mention softening of fine lines around the eyes and mouth.
  • AbsorptionPraised
Reviews
  • We Cut Through the Anti-Aging Hype to Find Skin Care You’ll Actually Use

Questions and answers

Which is better for sensitive skin?
The YOUTHFUL. It is peptide-based, has no retinol and is listed for all skin types, while the SkinMedica is only for skin already conditioned with a lower-strength retinoid.
Can I use both together?
Yes, but not in the same routine at first. Use the SkinMedica retinol at night on alternate days and the YOUTHFUL peptide serum in the morning, and add SPF every day.
Which works faster on wrinkles?
Retinol usually shows texture and tone changes over weeks of consistent use, but it starts at twice a week. The YOUTHFUL gives faster hydration and smoothing, with firmness building over time.
Which lasts longer per bottle?
The SkinMedica, at 1 fl. oz. against 0.5 oz. for the YOUTHFUL. But the SkinMedica is used twice a week at first, while the YOUTHFUL is used daily, so the gap in how long each lasts is smaller than the sizes suggest.
Is the SkinMedica worth stepping up to?
Only if your skin already tolerates retinol and texture or coarse wrinkles are your main concern. If you are new to retinoids or have sensitive skin, start with the YOUTHFUL.
Can I use the YOUTHFUL around my eyes?
Yes. It is made for the eye area as well as the face, and owners report lighter-looking under-eyes. The SkinMedica is labeled for the face only.

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Buying guides that pick them

  • Best anti-aging skincare products for mature skin
—
Item Count1—
Product Form—Retinol-based treatment
Application Area—face
Use Frequency—twice a week
Sun Protection—SPF 30 or higher
Content—Retinol
suggestedGender—Unisex
suggestedAge—Adult
Users like that it sinks in quickly and layers under moisturizer and sunscreen.