Is the Dell 6T6TD a good drive for a home NAS?

It works in a NAS with enough bays and cooling, but it is an enterprise 7200 RPM drive. It is louder and draws more power than a 5400-class NAS drive, and it is not on every NAS maker's compatibility list.

Will it work in a Dell PowerEdge server?

The 6T6TD is a Dell-qualified part, so it is the right choice for PowerEdge and PowerVault systems that list it as supported. Check your model's drive compatibility list before buying.

What interface does it use?

It is a SATA 6Gb/s drive in the 3.5-inch form factor. It connects to a standard SATA backplane or controller, not to an SAS-only bay.

At 7200 RPM with an 8TB platter set, expect sequential reads and writes in the high hundreds of MB/s at best, well below SATA SSDs. Random small-file performance is typical of a hard drive.

Does it come with a drive caddy or screws?

It is sold as a bare drive. Dell servers usually need the correct drive carrier or caddy for your chassis, which is a separate part.

Is it worth choosing over a cheaper 8TB desktop drive?

Choose it when your Dell system requires a qualified part or you need 24/7 duty. For a single desktop or light NAS, a consumer or NAS-class 8TB drive is quieter and easier on power.