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Denamarin
Denamarin for Dogs

Denamarin for Dogs

4· 1,500 ratings

Best price now

$44.99at Chewy.comObserved at 3:44 PM

Compared across 3 stores. Prices are checked against each store and labelled with when.

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Our take on the Denamarin for Dogs

Denamarin is a veterinary liver supplement for dogs that combines S-adenosylmethionine (SAMe) with silybin, the active part of milk thistle. It is sold as chewable tablets in a liver flavor and is commonly used to support liver function in dogs with liver disease or elevated liver enzymes. The 30-count box at $44.99 at Chewy.com as of November 4, 2026 is the lowest of the three stores listing it new.

Best forDogs with liver disease or elevated liver enzymesDogs on a vet-prescribed liver support planOwners who want a chewable tablet rather than a capsuleMulti-size households, since dosing scales with weight
Pros
  • Combines SAMe and silybin, two ingredients with the most veterinary evidence behind them
  • Chewable liver-flavored tablet is easier to give than a capsule
  • Silybin is formulated for better absorption than plain milk thistle extract
  • Dosing is weight-based, from small dogs up to dogs over 105 lbs
  • Widely stocked, so refills are easy to find
Cons
  • Requires a vet's guidance; it is not a substitute for treating the underlying cause
  • Tablets must be given on an empty stomach for best absorption, which takes planning
  • A 30-count box runs out fast for large dogs at 4 tablets a day
  • Sold in one box size, so heavy dogs need frequent repurchases
  • Not a cure for liver disease, only support

Denamarin for Dogs prices at every store

  • Chewy.comNew

    In stock

    $44.99Observed at 3:44 PM
    Visit store
  • WalmartNew

    In stockSold by California Pet Pharmacy

    $44.99Observed at 3:44 PM
    Visit store
  • PetCareRxNew

    In stock

    $45.00Observed at 3:44 PM
    Visit store

Also available at

  • PetMedsCheck price at PetMeds
  • Allivet Pet PharmacyCheck price at Allivet Pet Pharmacy
  • Bandana RxCheck price at Bandana Rx
  • Heartland Veterinary Supply and PharmacyCheck price at Heartland Veterinary Supply and Pharmacy
  • Jefferspet.comCheck price at Jefferspet.com
  • PetSmartCheck price at PetSmart
  • Tractor Supply CompanyCheck price at Tractor Supply Company
  • Valley Vet SupplyCheck price at Valley Vet Supply
  • VetRxDirect a Pet PharmacyCheck price at VetRxDirect a Pet Pharmacy

Denamarin for Dogs price history

Lowest price we've seen: $44.99 on Nov 4 at Chewy.com. Tracked across 12 stores since Nov 4.

What reviewers say

Owners and vets generally rate Denamarin well, with a 4 out of 5 average across about 1,500 ratings. Most praise comes from dogs whose liver values improved on recheck bloodwork. Complaints center on cost and on dogs refusing the tablet.

Pros
  • Liver enzyme values often improve on follow-up bloodwork
  • Chewable form is accepted by many dogs
  • Vets recommend it by name, which builds trust
  • Easy to dose by weight
Cons
  • Expensive for ongoing use
  • Some dogs refuse the liver flavor or spit it out
  • Empty-stomach timing is inconvenient
  • Large dogs burn through a box quickly

Specifications

Life Stage
All Lifestages, Adult
Health Benefit
Liver health
Health Concern
Liver Disease
Minerals
Zinc (when administered with Marin Plus for Dogs)
Supplement Type
Liver supplement
Vitamins
Vitamin E (when administered with Marin Plus for Dogs)
Primary Use
Liver health, Liver health support
Animal Type
Dog
Breed Size
All sizes
Active Ingredients
S-Adenosylmethionine, Silybin
Ingredient Highlights
Silybin (a bioactive component of milk thistle extract)
Administration Dosage
4 tablets (Over 105 lbs)
Dosage Strength
225 mg (S-Adenosylmethionine)
Dosage Unit
Tablet
Packaging Count
30 tablets
Packaging Size
30 count
Packaging Type
Box
Formulation Type
Chewable Tablet
Flavor
Liver
Formulation Texture
Chewable
Formulation Highlights
More bioavailable silybin than standardized milk thistle extract
Storage Instructions
Store in a cool, dry area

Questions and answers

Is Denamarin worth it for a dog with elevated liver enzymes?
Many vets consider it the standard liver support supplement, and owners often see enzyme values drop on rechecks. It supports the liver but does not treat the underlying disease, so use it alongside your vet's plan.
How does Denamarin differ from plain milk thistle?
Denamarin pairs silybin with SAMe, while milk thistle products supply silybin alone. Its silybin is also formulated for better absorption than standard milk thistle extract.
How many tablets does my dog need?
Dosing is by weight and set by your vet. The largest listed dose is 4 tablets for dogs over 105 lbs, and smaller dogs take fewer.
Can I give Denamarin with food?
It works best given on an empty stomach, at least an hour before a meal, because absorption drops with food. Ask your vet if your dog cannot tolerate that schedule.
What is in the box?
One box of 30 chewable liver-flavored tablets. Store it in a cool, dry area.
When is Denamarin cheapest?
The best new price was $44.99 at Chewy.com as of November 4, 2026, with three stores listing it new. Compare across stores before each refill, since prices move.
Where is the Denamarin for Dogs cheapest?
At Chewy.com, for $44.99, as of our latest check.
What do buyers say about the Denamarin for Dogs?
Rated 4 out of 5 from 1,500 ratings.
Where can I buy the Denamarin for Dogs?
12 stores we checked sell it, including Chewy.com, Walmart, PetCareRx, PetMeds, Allivet Pet Pharmacy.