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Desitin
Desitin Daily Defense Baby Diaper Rash Cream with Zinc Oxide

Desitin Daily Defense Baby Diaper Rash Cream with Zinc Oxide

5· 1 rating

Best price now

$6.28at AmazonObserved at 10:13 AM

35% under what the other stores charge

Compared across 3 stores. Prices are checked against each store and labelled with when.

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Our take on the Desitin Daily Defense Baby Diaper Rash Cream with Zinc Oxide

Desitin Daily Defense is a fragrance-free diaper rash cream built on 13% zinc oxide, the standard skin protectant strength for treating and preventing rash. It is hypoallergenic and both pediatrician- and dermatologist-tested, and it skips parabens, phthalates, dyes and fragrance. The 4 oz tube is widely stocked, and the best new price is $6.28 at Amazon as of November 5, 2026, with 3 stores listing it new.

Best forParents treating an active diaper rashDaily prevention on rash-prone skinFragrance-sensitive babiesDiaper bag and nursery stocking
Pros
  • 13% zinc oxide, a proven rash protectant
  • Fragrance-, dye-, paraben- and phthalate-free
  • Hypoallergenic and pediatrician/dermatologist tested
  • Thick cream stays put on the diaper area
  • Low cost per tube at about $6.28
Cons
  • Thick formula can be hard to wipe off
  • Only a 4 oz tube; frequent changers will rebuy often
  • Not a substitute for a doctor visit on severe or yeast rashes
  • No fragrance means a plain, medicinal smell

Desitin Daily Defense Baby Diaper Rash Cream with Zinc Oxide prices at every store

  • eBayNew

    In stock

    $12.33Free shippingObserved at 10:13 AM
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  • StaplesNew

    In stock

    $9.69+ $9.95 shippingObserved at 10:13 AM
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  • AmazonNew

    Availability unknown

    As an Amazon Associate, Deal.ai earns from qualifying purchases.

    $6.28Observed at 10:13 AM
    Visit store

Desitin Daily Defense Baby Diaper Rash Cream with Zinc Oxide price history

Lowest price we've seen: $6.28 on Nov 5 at Amazon. Tracked across 3 stores since Nov 5.

What reviewers say

Reception is thin, with a single 5-out-of-5 rating on record, so treat the score as anecdotal. Desitin's zinc oxide creams are generally well regarded by parents for calming rash quickly.

Pros
  • Soothes rash within a day or two for many users
  • Thick barrier that stays on through the night
  • No fragrance or dye, so less irritation
Cons
  • Hard to spread and wipe off
  • Can leave white residue on diapers and clothing

From Staples

  • 4-ounce tube of Desitin Daily Defense Baby Diaper Rash Cream
  • Works from the first use to soothe, treat and prevent diaper rash
  • Instantly forms a protective layer on baby's skin
  • Made with 13% zinc oxide skin protectant
  • Hypoallergenic, pediatrician-tested and dermatologist-tested formula
  • Free of parabens, phthalates, fragrances and dyes
Materials
13% zinc oxide skin protectant; paraben-, phthalate-, fragrance- and dye-free
Returns
Free returns online and in store, always free
Shipping
Free shipping on qualifying orders

About the Desitin Daily Defense Baby Diaper Rash Cream with Zinc Oxide

Get Desitin Daily Defense Diaper Rash Cream, 4 Oz (2091454) fast at Staples. Free next-day delivery when you spend $35+.

Specifications

Form
Cream
Hypoallergenic
Yes
Active ingredient
Zinc Oxide 13%Source
Purpose
Skin ProtectantSource
Dosage form
creamSource

Questions and answers

Is Desitin Daily Defense worth it over the classic purple Desitin?
Daily Defense is the fragrance-free, dye-free version, which suits sensitive skin. Classic Desitin has a stronger scent and a higher zinc oxide level in some versions, so pick Daily Defense if fragrance is a concern.
How much zinc oxide does it contain?
13%, or 130 mg per gram. That is a standard OTC skin protectant level for diaper rash.
Is it safe for newborns and daily use?
It is an OTC skin protectant labeled for diaper rash and is pediatrician-tested. Ask your pediatrician for babies under 6 weeks or for broken, bleeding skin.
What is in the box?
One 4 oz (136 g) tube of cream. No applicator or other accessories.
When is it cheapest?
The best new price on record is $6.28 at Amazon as of November 5, 2026. Subscribe-and-save and multipacks usually beat single-tube prices.
Where is the Desitin Daily Defense Baby Diaper Rash Cream with Zinc Oxide cheapest?
At Amazon, for $6.28, 35% under what the other stores charge, as of our latest check.
What do buyers say about the Desitin Daily Defense Baby Diaper Rash Cream with Zinc Oxide?
Rated 5 out of 5 from 1 ratings.
Where can I buy the Desitin Daily Defense Baby Diaper Rash Cream with Zinc Oxide?
3 stores we checked sell it, including Staples, eBay, Amazon.

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Administration route
TOPICALSource
Net weight
4.8 Oz (136 g)Source
Free from
parabens, phthalates, dyes and fragranceSource
Storage temperature
20° to 25°C (68°F to 77°F)Source
Zinc oxide strength
130 mg in 1 gSource
Product type
HUMAN OTC DRUGSource
Series or Collection
Daily Defense
Capacity (oz.)
4
Formulation Type
Cream
Selling Quantity
1
Fragrance
Fragrance Free