Is the HP 500537-B21 worth buying?

Only if you are keeping a ProLiant DL385 G5p alive. At $74.00 at Global One Technology as of November 3, 2026, it is a cheap repair part, but a used complete server with more performance often costs about the same.

Which servers does this processor fit?

HP lists it for the ProLiant DL385 G5p base configuration. It uses AMD Socket F, so it will not fit G6 or later ProLiant models.

How does the Opteron 2378 compare with newer server CPUs?

It is roughly a decade and a half behind. A modern entry Xeon or EPYC core is several times faster per clock and uses less power for far more work.

The listing is for the processor itself. Heatsinks, thermal paste and any required BIOS updates are not included unless the seller states otherwise.

When is this processor cheapest?

Legacy server parts like this tend to fall in price as remaining stock sits. Check the price history before buying, since a single new listing can move the price sharply.

Where is the HP 500537-B21 Processor cheapest?

At Global One Technology, for $74.00, as of our latest check.

Where can I buy the HP 500537-B21 Processor?

7 stores we checked sell it, including CPU Medics, Global One Technology, ServerWorlds, Memory Clearance, GotoDirect.

HP 500537-B21 Processor

Best price now

$74.00at Global One TechnologyObserved Nov 3, 2026, 8:50 AM

Compared across 3 stores. Prices are checked against each store and labelled with when.

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Our take on the HP 500537-B21 Processor

The HP 500537-B21 is a single AMD Opteron 2378 quad-core server processor rated at 2.4 GHz with 6 MB of L3 cache and a 75 W TDP. HP sells it as a spare or upgrade part for the ProLiant DL385 G5p base configuration. It is a 2008-era Shanghai-core chip, so it suits keeping an old G5p running, not new builds. The best new price is $74.00 at Global One Technology as of November 3, 2026, with only one store listing it new.