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A 0.7 fl oz spot treatment cream built on 5.5% micronized benzoyl peroxide, aimed at individual pimples rather than whole-face use. La Roche-Posay markets it for sensitive skin and cites clinical grading of clearer skin in 1 day and up to 63% fewer inflammatory breakouts in 1 week. The best new price is $24.97 at Walmart as of November 7, 2026, with 4 stores listing it new.
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Lowest price we've seen: $24.99 on Nov 7 at Ulta Beauty. Tracked across 3 stores since Nov 7.
Rated 4.7 out of 5 from 462 ratings, buyers largely report fast visible shrinking of individual pimples. Complaints center on dryness, irritation and bleaching of fabrics, which are expected benzoyl peroxide trade-offs.
La Roche-Posay Effaclar BPO 5.5% is a benzoyl peroxide acne spot treatment cream for targeted breakouts, in a 0.7 fl oz size. This acne spot treatment uses 5.5% micronized benzoyl peroxide that starts killing acne-causing bacteria on contact and penetrates deeper into pores for focused blemish clearing. In clinical grading, the formula delivered visibly clearer skin and a reduction of breakouts in just 1 day, with up to a 63% reduction in inflammatory acne in 1 week, making it a fast-acting option for active blemishes. Apply a thin layer directly to affected areas once or twice daily as directed. Because benzoyl peroxide can increase sun sensitivity and may bleach fabrics, use sunscreen during the day and take care around towels and clothing. For shoppers who want a strong, targeted benzoyl peroxide spot treatment from a dermatologist-recommended brand, this Effaclar BPO cream focuses on clearing individual breakouts quickly.
