Is the MSI Modern AM272P good for gaming?

No. It uses integrated Intel graphics and a 65 W power supply, so it handles casual and older titles at low settings but not modern games. A desktop with a dedicated GPU is the better choice for gaming.

Is a 27-inch 1080p screen sharp enough?

It is usable for office work, video and browsing, but text looks less crisp than on a 1440p or 4K panel of the same size. If sharp text matters, look at higher-resolution all-in-ones.

Can I upgrade the RAM and storage?

The RAM is DDR5 SO-DIMM and the 1 TB SSD is replaceable, so upgrades are possible. Check the exact mainboard spec before buying, since listed maximum memory support varies by configuration.

Does it come with a keyboard and mouse?

MSI sells the AM272P as a bare all-in-one in most configurations, so plan on adding a USB or Bluetooth keyboard and mouse. Confirm the bundle with the seller before ordering.

Can I use it as a monitor for a laptop?

It has an HDMI port, but that is an output for a second display rather than a video input. To use the screen with a laptop you need a model with HDMI-in, which this is not.