Is this acrylic sheet strong enough for a table top?

At 0.22 inch thick over 36 inches, it will flex if unsupported. Use a solid base underneath or add support for heavier loads.

How does it compare with glass?

It is lighter and more shatter-resistant than glass, but it scratches more easily and should not be cleaned with harsh solvents.

Yes. Acrylic can be cut and drilled with standard woodworking tools. Go slowly to avoid melting or cracking.

The sheet is 0.22 inch thick, which is a little under a quarter inch.

Use a soft cloth with mild soap and water. Avoid ammonia-based cleaners and abrasive pads, which can haze or scratch the surface.

At The Home Depot, for $137.35, as of our latest check.

$137.35at The Home DepotChecked 18 h ago

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