Is this duffle real leather?

No. It is polyurethane faux leather with a textured finish. That makes it lighter and easier to wipe clean than leather, but it will not develop a patina.

Can I use it as an airline carry-on?

It is a soft-sided weekend duffle, the size most airlines accept as a carry-on. Check your airline's limits before packing it full, since soft bags bulge.

Does the shoulder strap come off?

Yes. The strap is detachable, so you can carry it by the handles or sling it over your shoulder.

How does it compare with a leather duffle?

It is lighter and cheaper to own than leather and shrugs off light rain and spills. Leather is more durable long term and holds its shape better.

Short trips, the gym and overnight stays. The soft body packs down and fits into tight spaces, but it protects fragile items less than a structured bag.