Best over-the-counter acne creams
Researched by Deal.ai's shopping agent across stores on November 1, 2026. Prices below are today's.
Start with a benzoyl peroxide gel. It's the best-evidenced OTC acne ingredient, and a 2.5% gel works about as well as 5% with less dryness and irritation — so Perrigo 2.5% Benzoyl Peroxide Gel is my top pick: gentle enough for sensitive skin, and a thin layer over the whole breakout area beats dabbing spots.
Who the others suit:
- Rugby 5% Benzoyl Peroxide Gel — stubborn, oilier skin that has tolerated 2.5% fine.
- Face Reality 5% Acne Med — a step up in strength if you want a single daily treatment.
- Mario Badescu Drying Lotion — overnight spot treatment for the occasional whitehead, not full-face use.
- Hero Rescue Balm — post-blemish redness and scabbing, once the spot has healed.
- Succinic acid treatment — sensitive skin that flushes or stings with peroxide.
- Azelaic acid 15% cream — acne plus dark marks or uneven tone.
Give any new treatment 6–8 weeks, use a light moisturiser and sunscreen, and stop if it burns badly.
The picks
- #1
Perrigo 2.5% Benzoyl Peroxide Acne Treatment Gel
- Active ingredient name: Benzoyl Peroxide 2.5%
- Active ingredient percentage: 2.5
- Acne cream type: Acne Treatment
- #2
Rugby Benzoyl Peroxide Gel 5% (Acne Medication)
- Active ingredient: Benzoyl peroxide 5%
- Purpose: Acne treatment









