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Best over-the-counter acne creams

Researched by Deal.ai's shopping agent across stores on November 1, 2026. Prices below are today's.

Start with a benzoyl peroxide gel. It's the best-evidenced OTC acne ingredient, and a 2.5% gel works about as well as 5% with less dryness and irritation — so Perrigo 2.5% Benzoyl Peroxide Gel is my top pick: gentle enough for sensitive skin, and a thin layer over the whole breakout area beats dabbing spots.

Who the others suit:

  • Rugby 5% Benzoyl Peroxide Gel — stubborn, oilier skin that has tolerated 2.5% fine.
  • Face Reality 5% Acne Med — a step up in strength if you want a single daily treatment.
  • Mario Badescu Drying Lotion — overnight spot treatment for the occasional whitehead, not full-face use.
  • Hero Rescue Balm — post-blemish redness and scabbing, once the spot has healed.
  • Succinic acid treatment — sensitive skin that flushes or stings with peroxide.
  • Azelaic acid 15% cream — acne plus dark marks or uneven tone.

Give any new treatment 6–8 weeks, use a light moisturiser and sunscreen, and stop if it burns badly.

The picks

  1. Perrigo
    Perrigo 2.5% Benzoyl Peroxide Acne Treatment Gel
    #1

    Perrigo 2.5% Benzoyl Peroxide Acne Treatment Gel

    • Active ingredient name: Benzoyl Peroxide 2.5%
    • Active ingredient percentage: 2.5
    • Acne cream type: Acne Treatment
    $15.19at WalmartObserved Nov 1, 2026, 6:43 PMPrices and history →
  2. Rugby
    Rugby Benzoyl Peroxide Gel 5% (Acne Medication)
    #2

    Rugby Benzoyl Peroxide Gel 5% (Acne Medication)

    • Active ingredient: Benzoyl peroxide 5%
    • Purpose: Acne treatment

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  • Dosage form: gel
  • $6.99at Hargraves Online HealthcareObserved Nov 1, 2026, 6:44 PMPrices and history →
  • Face Reality
    Face Reality 5% Acne Med
    #3

    Face Reality 5% Acne Med

    • Active ingredient: Benzoyl Peroxide 5%
    • Skin types: normal and oily skin types
    • Fitzpatrick types: Fitzpatrick Type:1-3
    $29.00at Skin Love CreamObserved Nov 1, 2026, 6:44 PMCompare 3 stores →
  • D
    Drying Lotion
    #4

    Drying Lotion

    • Body Part: Face
    • Form: Lotion
    • Skin Type: All Skin Types
    $18.00at Mario BadescuObserved Nov 1, 2026, 6:44 PMPrices and history →
  • R
    Rescue Balm
    #5

    Rescue Balm

    • Size: 15 ml / 0.5 fl oz
    • Use frequency: once daily
    • Key ingredient: Panthenol
    $12.99at Hero CosmeticsObserved Nov 1, 2026, 6:44 PMPrices and history →
  • S
    Succinic Acid Acne Treatment
    #6

    Succinic Acid Acne Treatment

    • Type: Topical
    • Active Ingredients: Salicylic Acid, Sulfur
    • Sustainability: Cruelty-free
    $10.00at PoshmarkObserved Nov 1, 2026, 6:44 PMCompare 6 stores →
  • A
    Acne Treatment Cream
    #7

    Acne Treatment Cream

    • Active ingredient: AZELAIC ACID 15.00000%
    • Additional active: HYDROXYETHYLPIPERAZINE ETHANE SULFONIC ACID 0.50000%
    $24.99at Zytrell Skin Solutions Inc.Observed Nov 1, 2026, 6:44 PMPrices and history →
  • B
    Benzoyl Peroxide Acne Treatment Cream 5%
    #8

    Benzoyl Peroxide Acne Treatment Cream 5%

    • Active ingredient: Benzoyl Peroxide 5.0%
    • Purpose: Acne Treatment
    • Application frequency: one to three times per day
    $30.00at Dr. Bailey Skin CareObserved Nov 1, 2026, 6:44 PMPrices and history →
  • M
    Maximum Strength Acne Gel Cream
    #9

    Maximum Strength Acne Gel Cream

    • Form: Gel Cream
    • Skin Type: All skin types, Acne-prone skin
    • Skin Concerns: Uneven skin texture, Acne, Blemishes
    $12.00at Ulta BeautyObserved Nov 1, 2026, 6:44 PMCompare 3 stores →
  • F
    Fighter Gel - Breakout Calming Gel
    #10

    Fighter Gel - Breakout Calming Gel

    • Body Part: Skin
    • Form: Gel
    • Skin Type: Oily/acne-prone, Acne-prone skin, All skin types
    $49.00at BanishObserved Nov 1, 2026, 6:44 PMCompare 2 stores →