Best single-socket ATX workstation motherboards with DDR4

Top pick: ASUS Pro WS W680-ACE (LGA 1700, ATX). It's the cleanest fit for a single-socket DDR4 workstation: a proper Pro WS board with ECC memory support, plenty of PCIe and M.2 for GPUs and fast storage, and it's widely stocked, so replacement or RMA is easy. Pair it with a 12th–14th gen Intel Core or Xeon E chip.

Who the others suit:

• ASUS Pro WS W680-ACE IPMI — same board with remote management; worth it only if you run it headless or in a rack and need out-of-band access.
• Supermicro X11SRA-O (LGA 2066, C422) — for a Xeon W build where you want ECC RDIMMs and server-grade validation over modern platform features.
• ASRock Rack C422 WS/IPMI — a cheaper route into LGA 2066 with IPMI, but it's a pre-owned listing, so check warranty and seller history.
• ASUS Pro WS W480-ACE — a solid older Xeon W-1200 option if you already have that CPU.

Skip the EPYC and Z440 boards here: they're server/proprietary platforms, not DDR4 ATX workstation boards for a general build.