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La Roche-Posay Retinol B3 Serum vs Dr.Melaxin Cemenrete Cyano Pink Spicule Serum

Buy the La Roche-Posay Retinol B3 if you want a proven, dermatologist-recommended retinol with a niacinamide buffer for fine lines and sensitive skin. Buy the Dr.Melaxin Cemenrete Cyano Pink Spicule Serum set if you want a two-bottle niacinamide and spicule serum for a tightening, exfoliating effect and use it day or night. On price, the La Roche-Posay is $43.39 at StyleVana as of November 7, 2026, and it dropped to $19.99 on November 6, 2026, so watch its price history before buying. No price was given for the Dr.Melaxin set.

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La Roche-Posay
La Roche Posay Retinol B3

La Roche-Posay Retinol B3 Serum

La Roche Posay Retinol B3

4.3(487 ratings)
$43.39
at StyleVana
Observed at 10:52 AM
See all prices and details
Visit StyleVana

Store links may earn us a commission. Price via Klarna.

Choose the La Roche-Posay Retinol B3 if you want a true retinol serum for wrinkles and acne-prone skin, used at night, with fragrance-free, non-comedogenic, sensitive-skin-friendly formulas.

Pros
  • Pure retinol plus gradual-release retinol for lines and wrinkles
  • Niacinamide buffer suits sensitive skin when introduced slowly
  • Fragrance-free, oil-free, paraben-free, non-comedogenic
  • Also lists acne and acne scar concerns
  • Large 3.2 oz bottle
Cons
  • Night use only; needs daily sunscreen
  • Retinol can irritate at first, so start a few nights a week
  • Pricier at $43.39 than its recent $19.99 low
Dr.Melaxin
Dr.Melaxin Cemenrete Cyano Pink Spicule Serum 30ml 2-Piece Set

Dr.Melaxin Cemenrete Cyano Pink Spicule Serum

Dr.Melaxin Cemenrete Cyano Pink Spicule Serum 30ml 2-Piece Set

4.5(457 ratings)
See all prices and details

Choose the Dr.Melaxin Cemenrete Cyano Pink Spicule Serum set if you want a niacinamide and spicule serum you can use morning and night, and you prefer a two-piece set.

Pros
  • Niacinamide plus spicules for a tightening effect
  • Can be used morning and night
  • Free of synthetic fragrance and labeled hypoallergenic
  • Two 30 ml bottles in the set
  • Higher rating, 4.5 out of 5
Cons
  • No retinol, so weaker evidence for wrinkle reduction
  • Spicules can feel prickly on sensitive skin
  • Small 30 ml bottles
  • No price given to judge value

What separates them

La Roche-Posay Retinol B3 SerumDr.Melaxin Cemenrete Cyano Pink Spicule Serum
Active anti-aging ingredientPure retinol plus gradual-release retinol, buffered with vitamin B3 (niacinamide)Niacinamide with spicules and vitamin B12; no retinol
When to useNight only; retinol increases sun sensitivityDay and night
Skin feel and methodLightweight liquid serum, a few dropsSpicules gently stimulate the skin; pink tint
Skin type focusSensitive skin, non-comedogenic, fragrance-freeAll skin types, sensitive skin, free of synthetic fragrance
Acne and scar claimsLists whiteheads, blackheads and acne scarsLists wrinkles only
Size3.2 oz full size30 ml, two-piece set
Ratings4.3 out of 5 from 487 ratings4.5 out of 5 from 457 ratings
Price$43.39 at StyleVana as of November 7, 2026; low of $19.99 on November 6, 2026No price given

Price history

$44.98$19.99
Nov 2Nov 7
  • La Roche-Posay Retinol B3 Serum: lowest $19.99 on Nov 6 at eBay; $43.39 on Nov 7.
  • Dr.Melaxin Cemenrete Cyano Pink Spicule Serum: lowest $44.98 on Nov 2 at YesStyle.com.

Prices at every store

La Roche-Posay Retinol B3 Serum

  • StyleVanaNew

    In stock

    $43.39Free shippingObserved at 10:52 AM
    Visit StyleVana
  • WalmartNew

    In stock

    $44.97Free shippingObserved at 10:52 AM
    Visit Walmart
  • TargetNew

    In stock

    $44.99Free shippingObserved at 10:52 AM
    Visit Target
  • La Roche PosayNew

    In stock

    $44.99+ $8.00 shippingObserved at 10:52 AM
    Visit La Roche Posay

Also available at

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  • WalgreensCheck price at Walgreens
  • eBayCheck price at eBay

Store links may earn us a commission. Some prices via Klarna.

All 6 stores and price history →

Dr.Melaxin Cemenrete Cyano Pink Spicule Serum

  • YesStyle.comCheck price at YesStyle.com
Prices and history →

Specs compared

SpecLa Roche-Posay Retinol B3 SerumDr.Melaxin Cemenrete Cyano Pink Spicule Serum
Body PartFaceFace
FormSerumSerum
Skin TypeSensitive skinAll Skin Types
Active IngredientsRetinolNiacinamide
Key IngredientRetinol, Vitamin B3Vitamin B12, Spicules, Pink vitamin (Vitamin B1…
Skin ConcernsWrinklesWrinkles
ContainsRetinol, Vitamin B3Water, Glycerin, Niacinamide, Spicules
Free OfOil-free, Paraben-freeSynthetic fragrances
SubtypeHydrating serum, Anti-aging moisturizerHydrating serum
TypeSerumSerum
Face Treatment TypeSerumSerum
For BabiesNoNo
Show all 36 specsShow fewer specs
SpecLa Roche-Posay Retinol B3 SerumDr.Melaxin Cemenrete Cyano Pink Spicule Serum
For KidsNoNo
For MenYesNo
SizeFull Size30ml
Night / Day UseNightBoth
Tattoo CareNoNo
Use HighlightsUnder EyeUnder Eye
Acne Treatment TypeWhiteheads, Blackheads—
Scar Treatment TypeAcne scars—
Application TimeEvening—
Overnight Use

What reviewers say

La Roche-Posay Retinol B3 Serum

  • 4.3 / 5487 ratings

With 4.3 out of 5 from 487 ratings, most buyers report smoother, brighter skin and find the serum gentler than expected for a retinol. A minority describe irritation, dryness or peeling early on, and some find results slow.

What people mention
  • ToleranceMixedMany say it is gentler than other retinols, but some still get redness and flaking when starting.
  • TexturePraisedBuyers describe a lightweight, fast-absorbing serum that layers well under moisturizer.
  • ResultsMixedUsers report smoother, brighter skin after weeks, though some find the change slow or subtle.
  • IrritationCriticisedA share of reviewers mention stinging, dryness or peeling, especially in the first weeks.

Dr.Melaxin Cemenrete Cyano Pink Spicule Serum

  • 4.5 / 5457 ratings

Rated 4.5 out of 5 from 457 ratings, buyers generally rate it highly. The spicule tingle is the most divisive part of the experience.

What people mention
  • Spicule feelMixedBuyers describe a prickly, tingling sensation when the spicules go on.
  • HydrationPraisedUsers say skin feels moisturized after applying it.
  • FragrancePraisedThe fragrance-free formula is welcomed by sensitive-skin users.
  • FirmnessMixedSome report tighter, firmer skin; others see little change in wrinkles.

Questions and answers

Which is better for wrinkles?
The La Roche-Posay Retinol B3 has actual retinol, the ingredient with the strongest record for fine lines and wrinkles. The Dr.Melaxin relies on niacinamide and spicules for a tightening effect, which is milder.
Can I use the Dr.Melaxin serum with retinol?
Yes, but alternate them. Use the Dr.Melaxin in the morning and the La Roche-Posay retinol at night, and wear sunscreen daily.
Which suits sensitive skin better?
Both are labeled for sensitive skin and fragrance-free. The La Roche-Posay still contains retinol, so start it a few nights a week; the Dr.Melaxin's spicules can also feel prickly.
Is the La Roche-Posay worth $43.39?
It was $19.99 on November 6, 2026, and $43.39 at StyleVana on November 7, 2026. At the low it is a clear buy; at $43.39, compare the six stores before deciding.
Which lasts longer?
The La Roche-Posay is 3.2 oz in one bottle. The Dr.Melaxin set is two 30 ml bottles, about 2 oz total, so the La Roche-Posay lasts longer per bottle.

More comparisons

  • Clinique Even Better Clinical Radical Dark Spot Corrector + Interrupter vs La Roche Posay Retinol B3
Yes
—
Fragrance FreeYes—
GenderUnisex—
TextureLiquid—
Weight (oz)3.2—
ContentHyaluronic Acid, Glycerin, Retinol, Vitamin B, …—
PackagingBottle, Pipette—
Skin ConcernWrinkles, Acne—
No. of Pieces (pcs)1—
Volume (fl oz)1.0—
Effect—Tightening
Application Method—Gently stimulate skin regeneration (with spicul…
Tint Color—Pink
Suitable For—Sensitive Skin
Age Range—Adult