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Comfortis
Comfortis 810mg for Dogs 40-60 lbs, 6 Pack

Comfortis 810mg for Dogs 40-60 lbs, 6 Pack

4.6· 14 ratings

Best price now

$141.19at California Pet PharmacyObserved at 3:44 PM

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Our take on the Comfortis 810mg for Dogs 40-60 lbs, 6 Pack

Comfortis is a beef-flavored chewable flea tablet for dogs 40.1 to 60 lbs. Each tablet contains 810 mg of spinosad and is given once a month; the box holds a six-month supply. It starts killing fleas within 30 minutes and kills adults before they can lay eggs. The best new price is $141.19 at California Pet Pharmacy as of November 4, 2026, the only new price listed, so there is no recent range to compare it against.

Best forDogs 40-60 lbs with an active flea problemOwners who prefer a chew over a topicalMulti-dog homes that need a six-month supplyDogs that take beef-flavored tablets easily
Pros
  • Kills fleas fast, within 30 minutes of dosing
  • Oral chew, no greasy spot-on residue
  • Monthly dosing, 6 tablets per box
  • Beef flavor most dogs accept
  • Targets adult fleas before egg-laying
Cons
  • No tick or heartworm coverage
  • Prescription required in the US
  • Weight band is narrow: 40.1-60 lbs only
  • Not for puppies under 14 weeks
  • Flea-only protection means a separate tick product

Comfortis 810mg for Dogs 40-60 lbs, 6 Pack prices at every store

  • California Pet PharmacyNew

    In stock

    $141.19Observed at 3:44 PM
    Visit store

Comfortis 810mg for Dogs 40-60 lbs, 6 Pack price history

Lowest price we've seen: $141.19 on Nov 4 at California Pet Pharmacy. Tracked across 1 store since Nov 4.

What reviewers say

Owners rate it 4.6 out of 5 from 14 ratings. Most report fast flea knockdown and easy dosing with the beef chew.

Pros
  • Fleas gone within a day or two
  • Dogs take the chew without a fight
  • No mess compared with topicals
Cons
  • Some dogs refuse the taste
  • Vomiting in a few sensitive dogs
  • Cost per month adds up

Specifications

Targeted Pests
Fleas
Active Ingredient
Spinosad
Administration Method
Oral
Life Stage Age
Puppies 14 weeks or older, Kittens 14 weeks or older
Treatment Frequency
Monthly
Animal Type
Dogs
Dosage Concentration
810 mg Spinosad
Dosage Duration
30 days
Formulation Type
Chewable tablet
Formulation
Beef-flavored
Lifecycle Targeted
Adults (kills fleas before they can lay eggs)
Treatment Type
Treatment, Prevention
Supply Duration
6 Month Supply
Supply Amount
6 tablets
Weight Range
40.1-60 lbs
Contains
Spinosad
Package Type
Box, Box (Blue Box)
Scent
Beef-flavored

Questions and answers

Is Comfortis worth it over a topical?
If your dog has fleas and takes chews well, yes. It kills fleas within 30 minutes and leaves no residue. It does not cover ticks, so add a tick product if you need one.
What weight of dog is this for?
Dogs from 40.1 to 60 lbs. Each tablet is 810 mg of spinosad. Dogs outside that band need a different tablet strength.
How often do I give it?
One chew a month. The six-tablet box covers six months. Give it with food for best absorption.
Can puppies take it?
Only puppies 14 weeks or older. Younger puppies and pregnant or nursing dogs should be dosed under a vet's guidance.
Does it kill ticks or prevent heartworm?
No. Comfortis is flea-only. Use a separate tick and heartworm preventive if your dog is at risk.
When is it cheapest?
The best new price is $141.19 at California Pet Pharmacy as of November 4, 2026. That is about $23.50 per monthly dose. Prices on prescription flea products move with pharmacy stock, so compare before reordering.
Where is the Comfortis 810mg for Dogs 40-60 lbs, 6 Pack cheapest?
At California Pet Pharmacy, for $141.19, as of our latest check.
What do buyers say about the Comfortis 810mg for Dogs 40-60 lbs, 6 Pack?
Rated 4.6 out of 5 from 14 ratings.