Is a 27-inch 1080p screen sharp enough for office work?

It is usable, but text looks softer than on a 24-inch 1080p screen or a 27-inch 1440p or 4K panel. If you read small text all day, a higher-resolution rival is the better pick.

Can I upgrade the RAM or storage later?

On most all-in-ones like this, memory and storage are not meant to be swapped by the user. Buy the configuration you need up front; 32 GB and 1 TB should last years of office use.

Can it run games or edit video?

It uses integrated Intel graphics, so it handles light photo editing and casual games but struggles with modern 3D games and heavy video timelines. A desktop with a dedicated GPU is the better fit for those.

Does it come with a keyboard and mouse?

MSI typically bundles a wired or wireless keyboard and mouse with its Pro all-in-one models, but check the box contents for the specific configuration before buying.

How does it compare with a 24-inch all-in-one?

You get more screen room for side-by-side windows, but at the same 1080p resolution the pixels are spread thinner. The 24-inch model looks sharper; this one gives you more workspace.