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Neosporin Original is a triple-antibiotic first aid ointment for minor cuts, scrapes and burns. It combines neomycin, bacitracin and polymyxin B to help prevent infection, and the label claims it kills 99.9% of germs in as little as 15 minutes in lab studies. The 0.5 oz tube is a standard medicine-cabinet size. At $4.98 at Lowe's as of November 7, 2026, it sits at the low end of what the 7 stores listing it charge.
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Lowest price we've seen: $4.88 on Nov 7 at Walmart. Tracked across 7 stores since Nov 7.
With 4.8 out of 5 from 5,913 ratings, buyers largely report it works as expected for minor wounds and heals cuts without infection. The main complaints are skin irritation in people sensitive to neomycin and the greasy texture.
Neosporin Original First Aid Antibiotic Ointment is a Triple Antibiotic Ointment for minor wound care. This topical antibiotic provides long-lasting, 24-hour infection protection, killing 99.9% of germs in as little as 15 minutes in lab studies. It helps prevent infection and minimize the appearance of scars in minor cuts, scrapes, and burns. The wound care treatment features HeliDerm Technology, which creates a nourishing environment to help support the skin's natural healing process by helping the skin stay hydrated as it heals for healthier-looking results. Neosporin is a Number 1 Doctor Recommended Brand* and suitable for medicine cabinets at home, first aid kits for on-the-go care, and emergency kits for travel. Clean the wound, then apply a small amount of Neosporin Original Ointment on the affected area 1-3 times daily before applying a BAND-AID Brand Adhesive Bandage for extra protection. *IQVIA ProVoice Survey November 2025
