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Neosporin Original is a triple-antibiotic ointment for minor cuts, scrapes and burns. It claims 24-hour infection protection and kills 99.9% of germs in as little as 15 minutes in lab studies, and its HeliDerm base keeps the wound hydrated to help reduce scarring. The 0.5 oz tube is the small size meant for a medicine cabinet or travel kit. At $4.98 at Lowe's as of November 7, 2026, it sits at the low end of what this size typically costs.
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Lowest price we've seen: $4.88 on Nov 7 at Walmart. Tracked across 9 stores since Nov 7.
Rated 4.6 out of 5 from 424 ratings, buyers treat it as a dependable staple for minor wounds. Complaints center on the greasy texture and skin reactions in people sensitive to neomycin.
Neosporin Original First Aid Antibiotic Ointment is a Triple Antibiotic Ointment for minor wound care. This topical antibiotic provides long-lasting, 24-hour infection protection, killing 99.9% of germs in as little as 15 minutes in lab studies. It helps prevent infection and minimize the appearance of scars in minor cuts, scrapes, and burns. The wound care treatment features HeliDerm Technology, which creates a nourishing environment to help support the skin's natural healing process by helping the skin stay hydrated as it heals for healthier-looking results. Neosporin is a Number 1 Doctor Recommended Brand* and suitable for medicine cabinets at home, first aid kits for on-the-go care, and emergency kits for travel. Clean the wound, then apply a small amount of Neosporin Original Ointment on the affected area 1-3 times daily before applying a BAND-AID Brand Adhesive Bandage for extra protection. *IQVIA ProVoice Survey November 2025
