Is 2.5% benzoyl peroxide strong enough?

For single pimples, yes. Studies and dermatologists often find 2.5% works about as well as 5% or 10% with less irritation. Severe or widespread acne needs a fuller routine or a dermatologist.

Can I wear it under makeup?

Yes. The cream is designed to vanish, so it can go under makeup or sunscreen once it dries. Let it set for a minute first.

Will it bleach my clothes?

Benzoyl peroxide can bleach fabric. Let it dry fully and avoid white towels and pillowcases right after applying.

How often should I apply it?

Start once a day on clean, dry skin and build to 1 to 3 times daily if your skin tolerates it. Stop and cut back if peeling or stinging starts.

One 0.75 oz tube of cream. A 2-pack variant is also sold and costs less per tube.

The best new price was $12.99 at eBay as of November 8, 2026, at the low end of its recent range. Multi-packs usually lower the per-tube cost.

Neutrogena On-The-Spot Acne Spot Cream 2.5% Benzoyl Peroxide

Q: Where is the Neutrogena On-The-Spot Acne Spot Cream 2.5% Benzoyl Peroxide cheapest?

At eBay, for $12.99, 18% under what the other stores charge, as of our latest check.

Q: Where can I buy the Neutrogena On-The-Spot Acne Spot Cream 2.5% Benzoyl Peroxide?

5 stores we checked sell it, including CVS Pharmacy, eBay, ATC Medical, Carewell, Quensivo.

Best price now

$12.99at eBayObserved at 7:53 AM

18% under what the other stores charge

Compared across 4 stores. Prices are checked against each store and labelled with when. Store links may earn us a commission.

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Our take on the Neutrogena On-The-Spot Acne Spot Cream 2.5% Benzoyl Peroxide

What reviewers say

Owners of low-strength benzoyl peroxide spot creams generally find them effective on individual pimples with less irritation than stronger gels. Complaints center on dryness with repeated use and on bleaching of fabric.

What people mention

IrritationMixedUsers say 2.5% stings and dries less than stronger benzoyl peroxide, but overuse still flakes the skin.
Fabric bleachingCriticisedOwners report bleached towels and pillowcases where the cream touches fabric.
TexturePraisedThe cream vanishes into skin and layers under makeup without a visible white cast.
SpeedMixedSome see a pimple shrink within a day or two; others find it takes most of a week.

About the Neutrogena On-The-Spot Acne Spot Cream 2.5% Benzoyl Peroxide

Why you'll love it

• Clinically proven to start clearing blemishes from day 1, reducing the anxiety of waiting weeks for results

• Low 2.5% benzoyl peroxide strength treats breakouts effectively without the redness, peeling, or stinging of stronger formulas

• Vanishing, lightweight cream absorbs invisibly so it can be worn under makeup or sunscreen without residue

• Dermatologist-tested by Neutrogena, a heritage drugstore skincare brand parents already trust

• Multi-pack variant offers better per-unit value for households where more than one person treats breakouts

Perfect for

• Spot-treating an emerging pimple the moment it appears to shorten its lifespan

• Daily 1-3x application as part of a morning and nighttime acne routine

• Pre-event emergency treatment before school photos, dates, or job interviews

• Maintaining clear skin between dermatologist visits as an affordable OTC option

• Stocking a travel skincare kit with a TSA-friendly 0.75 oz tube (or two, via the 2-pack)

On-the-Spot Acne Spot Treatment

Fight acne without over-drying your face with Neutrogena On-the-Spot Acne Treatment. This medicated acne spot treatment is lightweight and absorbs quickly into skin. Neutrogena On-the-Spot Acne Spot Treatment contains just 2.5% benzoyl peroxide, yet is clinically proven to be so effective that skin starts getting clearer on day 1 - all without over-drying, stinging or burning skin. This acne-fighting formula goes deep down into pores to kill acne bacteria that causes pimples and helps stop new ones from forming.

CONTAINS BENZOYL PEROXIDE

Treatment is formulated with 2.5% benzoyl peroxide acne medicine, to help treat and prevent acne.

LIGHTWEIGHT & ABSORBS QUICKLY

This spot treatment has clinically proven effectiveness with no burning and won’t dry out skin.

#1 DERMATOLOGIST RECOMMENDED ACNE BRAND

Formulated from the #1 Dermatologist Recommended Acne Brand.

CLEANSE

Start your regimen with a cleanser to help remove the dirt & oil that builds over time.

TREAT

After you cleanse your skin, use Neutrogena On-the-Spot Acne Treatment to help treat & prevent acne without over drying the skin.