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Seresto Flea & Tick Collar for Dogs vs Vet's Best Topical Flea & Tick Treatment for Dogs

Pick Seresto if you want the longest-lasting, vet-recommended protection and don't mind a collar: one collar covers 8 months, works from 7 weeks of age, and is odorless and non-greasy. Pick Vet's Best if you prefer a plant-based spot-on and want to avoid synthetic insecticides, accepting monthly reapplication and a strong clove-thyme scent. Reviewers rate Seresto highly (4.4 from nearly 9,000 ratings) and report reliable flea and tick control; Vet's Best draws mixed feedback, with some owners citing the smell and inconsistent results.

  • Choose the Seresto collar if you want set-and-forget protection that lasts most of a year and is recommended by vets.
  • Choose the Vet's Best spot-on if you want a natural, plant-oil formula applied monthly instead of wearing a collar.

Prices

  • Seresto Flea & Tick Collar for Dogs: $107.99 at Petsmart (checked today)
  • Vet's Best Topical Flea & Tick Treatment for Dogs: $22.99 at Walmart (checked today)
  • Difference: the Vet's Best Topical Flea & Tick Treatment for Dogs is $85.00 cheaper than the Seresto Flea & Tick Collar for Dogs today
Seresto
Seresto Flea & Tick Collar For Dogs & Puppies Over 18 lbs., 8-Month Protection (2 Count)

Seresto Flea & Tick Collar for Dogs

Seresto Flea & Tick Collar For Dogs & Puppies Over 18 lbs., 8-Month Protection (2 Count)

4.4(8,922 ratings)
$107.99at PetsmartChecked 2 h ago
See all prices and details
Visit Petsmart

Store links may earn us a commission. Price via Klarna.

Pros
  • 8 months of flea and tick protection per collar
  • Kills and repels existing and new infestations
  • Odorless, non-greasy plastic collar
  • Safe for puppies from 7 weeks
  • Vet-recommended and highly rated by owners
Cons
  • Synthetic insecticides, not a natural formula
  • Collar must stay on the dog at all times
  • Some dogs show skin irritation at the collar site
Vet's Best
Vet's Best Topical Flea & Tick Treatment for Dogs

Vet's Best Topical Flea & Tick Treatment for Dogs

3.3(3 ratings)
$22.99at WalmartChecked 2 h ago
See all prices and details
Visit Walmart
Pros
  • Plant-based formula with clove, cinnamon and thyme oils
  • Monthly spot-on is easy to apply
  • Four-month supply in one pack
  • Made in the USA
Cons
  • Needs reapplication every month
  • Strong herbal odor some owners dislike
  • Not for puppies under 12 weeks
  • Cannot ship to AK, CA or HI

What separates them

Seresto Flea & Tick Collar for DogsVet's Best Topical Flea & Tick Treatment for Dogs
ApplicationPlastic collar worn continuouslySpot-on drops between the shoulder blades
Protection duration8 months per collarUp to 1 month per dose
Active ingredientsFlumethrin and imidacloprid (synthetic)Clove, cinnamon and thyme oils (plant-based)
Minimum age7 weeks12 weeks
ScentOdorlessStrong thyme, cinnamon and clove smell
Water resistanceStays effective after bathing and swimmingNot stated as water resistant; reapply monthly
Supply in pack2 collars (16 months total)4 monthly doses
Shipping limitsNo stated state restrictionsCannot ship to AK, CA or HI

Price history

  • Seresto Flea & Tick Collar for Dogs: lowest $107.99 on Nov 11 at Petsmart.
  • Vet's Best Topical Flea & Tick Treatment for Dogs: lowest $19.99 on Nov 11 at Scheels.

Prices at every store

Seresto Flea & Tick Collar for Dogs

  • PetsmartNew

    In stock

    $107.99+ $5.99 shippingChecked 2 h ago
    Visit Petsmart
  • WalmartNew

    In stock

    $115.97Free shippingChecked 2 h ago
    Visit Walmart
  • Tractor Supply CoNew

    Availability unknown

    $115.99Free shippingChecked 2 h ago
    Visit Tractor Supply Co

Store links may earn us a commission. Some prices via Klarna.

All 3 stores and price history →

Vet's Best Topical Flea & Tick Treatment for Dogs

  • WalmartNew

    In stockSold by Petco Animal Supplies, Inc.Returns: Sold by a Walmart Marketplace seller; returns go to the seller under the seller's returns policy.

    $22.99Checked 2 h ago
    Visit Walmart
  • Chewy.comNew

    In stock

    $22.81+ $4.95 shippingChecked 4 h ago
    Visit Chewy.com
  • ScheelsNew

    In stock

    $19.99+ $9.99 shippingChecked 4 h ago
    Visit Scheels
  • Talis UsNew

    Availability unknown

    $22.99Checked 4 h ago
    Visit Talis Us
All 5 stores and price history →

Specs compared

SpecSeresto Flea & Tick Collar for DogsVet's Best Topical Flea & Tick Treatment for Dogs
animal_typeLarge DogDog
colorWhiteOther
size2 Pack16 - 40 lbs
number_of_pieces2—
multipack_quantity1—
count_per_pack2—
No. of Packs (pack)2—
MaterialPlastic—
Weight (lb)0.4—
Targeted Pests—Fleas, Ticks
Active Ingredient—Clove oil, Cinnamon oil, Thyme oil
Administration Method—Spot-on
Show all 39 specsShow fewer specs
SpecSeresto Flea & Tick Collar for DogsVet's Best Topical Flea & Tick Treatment for Dogs
Life Stage Age—12 weeks or older
Treatment Frequency—Monthly
Dosage Concentration—7.5% (Clove Oil)
Dosage Duration—Up to one month
Formulation Type—Drops, Spot-on
Formulation—Plant-based formula
Suitable For Health Status—Safe for Dogs 12 Weeks and Older
Treatment Type—Treatment, Prevention
Supply Duration—4 month supply

What reviewers say

Seresto Flea & Tick Collar for Dogs

  • 4.4 / 58,922 ratings

Owners and reviewers largely rate Seresto highly for convenience and long-lasting flea and tick control, and many say it replaced monthly treatments. A minority report skin irritation, hair loss at the neck, or reduced effectiveness toward the end of the 8 months.

What people mention
  • DurationPraisedOwners like getting months of protection from one collar instead of monthly applications.
  • Skin irritationCriticisedSome owners report redness, itching or hair loss around the neck where the collar sits.
  • Water resistancePraisedReviewers say it keeps working after swimming and baths.
  • EfficacyMixedMany see fewer fleas and ticks, but some report pests returning before the 8 months are up.

Vet's Best Topical Flea & Tick Treatment for Dogs

Owners drawn to a natural option often like the easy tubes and the fact that it avoids harsh chemicals, but reception is split. Many report fleas returning within weeks or the product failing to clear an active infestation, and some mention a lingering scent or skin irritation.

What people mention
  • EffectivenessCriticisedMany owners say fleas persisted or returned, especially where an infestation was already established.
  • ScentMixedSome find the thyme and clove smell pleasant and mild; others say it lingers strongly on the dog.
  • Skin reactionCriticisedA number of owners report redness, scratching or irritation at the application site.
  • ApplicationPraisedThe pinch-and-squeeze tubes are described as quick and easy to part the fur and apply.

Questions and answers

Which is better for a dog that swims or gets bathed often?
Seresto. Its protection is designed to hold up through bathing and swimming for the full 8 months. Vet's Best is a monthly spot-on with no stated water resistance, so frequent wetting can shorten its effect.
Which lasts longer?
Seresto by far. One collar protects for 8 months, and this pack has two collars. Vet's Best covers up to one month per dose, with four doses in the pack.
Is Vet's Best safe for puppies?
Only for puppies 12 weeks and older. Seresto can be used from 7 weeks, so it suits younger puppies.
Is the natural formula as effective?
Owner feedback on Vet's Best is more mixed than on Seresto, which is vet-recommended and backed by years of use. If fleas or ticks are already a serious problem, Seresto is the more reliable choice.
Is Seresto worth stepping up to?
If you want fewer applications, no scent and longer coverage, yes. Choose Vet's Best instead if avoiding synthetic insecticides matters more to you than convenience.
Can I use either around cats?
Vet's Best states it is not for use on cats or kittens. Keep treated dogs and Seresto collars away from cats, and check with your vet before using either in a multi-pet home.

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More comparisons

  • Seresto Flea & Tick Collar For Dogs & Puppies Over 18 lbs., 8-Month Protection (2 Count) vs NexGard Chewables for Small Dogs 10.1–24 lbs (4.1–10 kg)
  • Vet's Best Topical Flea & Tick Treatment for Dogs vs NexGard Chewables for Small Dogs 10.1–24 lbs (4.1–10 kg)

Buying guides that pick them

  • Best flea and tick treatments for dogs under 40 lb
Supply Amount—4.6 Milliliters
Weight Range—Over 40 lbs, Over 40 lbs (large dogs)
Breed Restrictions—Not for use on cats or kittens
Contains—Clove oil, Cinnamon oil, Thyme oil
Free Of—Apple Free
Package Type—Pinch-and-Squeeze tubes
Scent—Thyme, Cinnamon, Clove
Dog weight range—over 40 lbs.
Minimum age—12 weeks or older
Protection duration—up to one month
Supply length—4 month supply
Application type—Pinch-and-Squeeze tubes
Active ingredients—Clove, Thyme and Cinnamon oils
Life stage—Adult
Product type—Spot-On Treatment
Dog size—S, XS, L, M
Weight—0.1 lbs
Package dimensions—6.85x3.62x1.1 inches