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Simparica Chewable Tablets for Dogs vs NexGard Chewable Flea Treatment for Dogs

Both are monthly beef-flavored chews that kill fleas and ticks, and both rate 4.7. Simparica starts killing fleas faster (about 3 hours vs about 4) and ticks within 8 hours, and it is labeled for dogs from 6 months and 2.8 lb. NexGard is labeled from 8 weeks and 4 lb, so it fits younger puppies, and it has a much larger review base. Pick Simparica for speed and a lower weight floor; pick NexGard for puppies under 6 months or if your dog needs a protein-free chew.

  • Choose the Simparica if you want the fastest flea kill and a chew your dog can take from 2.8 lb and 6 months of age.
  • Choose the NexGard if you have a puppy as young as 8 weeks or a dog with food sensitivities who needs a protein-free chew.

Prices

  • Simparica Chewable Tablets for Dogs: $28.60 at Amazon (last seen Nov 10)
  • NexGard Chewable Flea Treatment for Dogs: $20.74 at Bandana Rx (last seen Nov 10)
  • Difference: the NexGard Chewable Flea Treatment for Dogs is $7.86 cheaper than the Simparica Chewable Tablets for Dogs at the latest prices (Nov 10)
Simparica
Simparica Chewable Tablets for Dogs

Simparica Chewable Tablets for Dogs

4.7(4,700 ratings)
$28.60at AmazonChecked 19 h ago
See all prices and details
Visit Amazon

As an Amazon Associate, Deal.ai earns from qualifying purchases.

Pros
  • Kills fleas within 3 hours, the fastest of the two
  • Kills ticks within 8 hours
  • Works for dogs as small as 2.8 lb
  • Chewable tablet most dogs take without a fight
  • Also helps control flea allergy dermatitis
Cons
  • Not labeled for puppies under 6 months
  • No stated waterproof or swimming claim
  • Smaller review base than NexGard
  • Prescription required
NexGard
NexGard for Dogs

NexGard Chewable Flea Treatment for Dogs

NexGard for Dogs

4.7(25,000 ratings)
$20.74at Bandana RxChecked 20 h ago
See all prices and details
Visit Bandana Rx
Pros
  • Labeled for puppies from 8 weeks and 4 lb
  • Free of animal proteins, useful for food-sensitive dogs
  • Kills fleas before they lay eggs
  • Waterproof claim covers bathing and swimming
  • Large review base of about 25,000 ratings
Cons
  • Flea kill starts about an hour later than Simparica
  • Higher minimum weight of 4 lb
  • Prescription required

What separates them

Simparica Chewable Tablets for DogsNexGard Chewable Flea Treatment for Dogs
Active ingredientSarolaner (isoxazoline)Afoxolaner (isoxazoline)
Flea kill speedStarts killing fleas within 3 hoursStarts killing fleas within about 4 hours
Tick kill speedStarts killing ticks within 8 hoursKills ticks on administration; label does not state an 8-hour figure
Minimum age6 months and older8 weeks and older
Minimum weight2.8 lb4 lb
Protein contentBeef-flavored chew; label does not claim protein-freeBeef-flavored but formulated free of animal proteins
Review base4.7 from about 4,700 ratings4.7 from about 25,000 ratings
Waterproof claimLabel does not state a bathing or swimming claimLabel states it is not affected by bathing or swimming

Price history

$33.95$20.74
Nov 4Nov 11
  • Simparica Chewable Tablets for Dogs: lowest $24.71 on Nov 4 at Petco.com; $28.60 on Nov 11.
  • NexGard Chewable Flea Treatment for Dogs: lowest $20.74 on Nov 11 at Bandana Rx.

Prices at every store

Simparica Chewable Tablets for Dogs

  • Chewy.comNew

    In stock

    $28.60+ $4.95 shippingChecked 19 h ago
    Visit Chewy.com
  • AmazonNew

    Availability unknown

    As an Amazon Associate, Deal.ai earns from qualifying purchases.

    $28.60Checked 19 h ago
    Visit Amazon
  • PetSupplies4Less.comNew

    Availability unknown

    $69.37Checked Nov 4
    Visit PetSupplies4Less.com
  • Tractor Supply CompanyNew

    Availability unknown

    $69.37Checked Nov 4
    Visit Tractor Supply Company

Also available at

  • Petco.comCheck price at Petco.com
All 14 stores and price history →

NexGard Chewable Flea Treatment for Dogs

  • ubereats.comNew

    In stockMade for another market

    $28.55Checked Nov 9
    Visit ubereats.com
  • Jefferspet.comNew

    In stock

    $37.29Checked 20 h ago
    Visit Jefferspet.com
  • Bandana RxNew

    Availability unknown

    $20.74Checked 20 h ago
    Visit Bandana Rx
  • VetShopMaxNew

    Availability unknown

    $33.95Checked Nov 4
    Visit VetShopMax
All 15 stores and price history →

Specs compared

SpecSimparica Chewable Tablets for DogsNexGard Chewable Flea Treatment for Dogs
AnimalDog—
Targeted Pests—Fleas
Active Ingredient—Afoxolaner
Administration Method—Chewable tablet
Weight Range—8.1-17 lbs
Life Stage Age—Puppies 8 weeks or older
Treatment Frequency—Monthly
Dosage Concentration—68 mg afoxolaner per chewable
Dosage Duration—One full month (30 days)
Formulation Type—Chewable
Formulation—Waterproof, Not affected by bathing or swimming
Lifecycle Targeted—Adult ticks, Adult fleas
Show all 23 specsShow fewer specs
SpecSimparica Chewable Tablets for DogsNexGard Chewable Flea Treatment for Dogs
Animal Type—Dogs
Suitable For Health Status—Dogs with food sensitivities or allergies
Treatment Type—Treatment, Prevention
Supply Duration—1 month supply
Supply Amount—6 chews
Contains—Afoxolaner
Free Of—Animal proteins
Scent—Unscented
Flavor—Beef
Size

What reviewers say

Simparica Chewable Tablets for Dogs

  • 4.7 / 54,700 ratings

Rated 4.7 out of 5 across about 4,700 ratings, with owners reporting strong flea and tick control and dogs taking the chew readily. Complaints are few and mostly about the prescription step and the need for a separate heartworm product.

What people mention
  • EffectivenessPraisedOwners say it clears and prevents fleas and ticks well.
  • TastePraisedDogs take the chew readily, so owners do not have to force it.
  • PrescriptionCriticisedBuyers note it needs a vet prescription before ordering.
  • CoverageMixedOwners point out it covers fleas and ticks but not heartworm.

NexGard Chewable Flea Treatment for Dogs

  • 4.7 / 525,000 ratings

With 4.7 out of 5 from about 25,000 ratings, owners mostly report fast flea control and easy dosing. Complaints center on stomach upset in some dogs and the need for a prescription.

What people mention
  • EffectivenessPraisedOwners say fleas and ticks clear up quickly, often within a day or two.
  • TastePraisedMost dogs eat the beef-flavored chew without fuss.
  • Stomach upsetCriticisedSome owners report vomiting or loose stools after dosing.
  • WaterproofingPraisedBathing and swimming do not seem to reduce protection.

Questions and answers

Which is better for a puppy?
NexGard. It is labeled for puppies from 8 weeks and 4 lb, while Simparica starts at 6 months and 2.8 lb.
Which kills fleas faster?
Simparica, which starts killing fleas within 3 hours against about 4 hours for NexGard.
Does either one stop working after a bath?
NexGard's label states it is not affected by bathing or swimming. Simparica's label does not make that claim.
Is one better for a dog with food allergies?
NexGard is formulated free of animal proteins, which matters for some food-sensitive dogs. Simparica's label does not make that claim.
Do both cover ticks?
Yes. Both are isoxazoline chews that kill fleas and ticks for about a month per dose.
Is it worth stepping up to one over the other?
Only if a specific label difference fits your dog: puppy age, minimum weight, protein-free formulation or faster flea kill. Otherwise they are close.

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More comparisons

  • Simparica Chewable Tablets for Dogs vs Nutri-Vet Guard Plus Flea & Tick Treatment for Dogs
  • Nutri-Vet Guard Plus Flea & Tick Treatment for Dogs vs NexGard for Dogs
—
4-10 lbs, 10.1-24 lbs, 24.1-60 lbs, 60.1-121 lbs
Count—1 Tablet, 3 Tablets, 6 Tablets