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Elanco Advantage II Flea Treatment for Dogs

Elanco Advantage II Flea Treatment for Dogs

Best price now

$50.99at Chewy.comObserved at 5:33 AM

Compared across 3 stores. Prices are checked against each store and labelled with when.

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Our take on the Elanco Advantage II Flea Treatment for Dogs

Advantage II is a monthly topical flea treatment for dogs from Elanco. It pairs imidacloprid, which kills adult fleas, with pyriproxyfen, which stops eggs and larvae from developing, so it breaks the flea life cycle rather than just killing what is on the dog. It is waterproof after 24 hours, fragrance-free, and approved for dogs at least 7 weeks old. The 6-count box for dogs 21-55 lbs is $50.99 at Chewy.com as of November 4, 2026, the best of three stores listing it new.

Best for
Dog owners treating an active flea problem
Multi-dog homes that need a monthly routine
Dogs that swim or get bathed often
Owners who prefer a topical over an oral pill
Pros
  • Kills adult fleas and stops eggs and larvae from developing
  • Waterproof after 24 hours, so bathing and swimming are fine
  • Fragrance-free formula
  • One dose lasts 30 days
  • Approved for puppies from 7 weeks old
Cons
  • Does not treat ticks or mites
  • Must be reapplied every month
  • Dose is matched to weight, so the 21-55 lb box won't fit small or very large dogs
  • Toxic to cats and must not be used on them
  • Some dogs dislike the oily spot at application

Elanco Advantage II Flea Treatment for Dogs prices at every store

  • WalmartNew

    In stock

    $50.99Free shippingObserved at 5:33 AM
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  • Chewy.comNew

    In stock

    $50.99Free shippingObserved at 5:33 AM
    Visit store
  • PetSmartNew

    In stock

    $52.99+ $6.99 shippingObserved at 5:33 AM
    Visit store

Elanco Advantage II Flea Treatment for Dogs price history

Lowest price we've seen: $50.99 on Nov 4 at Walmart. Tracked across 3 stores since Nov 4.

What reviewers say

Owners generally report that Advantage II clears fleas within a day or two and keeps them away with monthly use. Complaints tend to be about the oily residue at the application site and about fleas returning when doses are skipped.

Pros
  • Fast knockdown of adult fleas
  • Easy to apply between the shoulder blades
  • No strong smell
  • Works well alongside home cleaning
Cons
  • Oily spot that lingers for a day or two
  • Needs strict monthly timing to keep working
  • No tick coverage
  • Not effective for every dog in heavy infestations

Specifications

Targeted Pests
Fleas
Active Ingredient
Imidacloprid, Pyriproxyfen
Administration Method
Topical, Topical treatment, Topical application
Life Stage Age
At least 7 weeks of age
Treatment Frequency
Monthly
Dosage Concentration
0.46% (Pyriproxyfen)
Dosage Duration
30 days
Formulation Type
Topical Solution
Formulation
Waterproof (after 24 hours)
Lifecycle Targeted
Adult fleas, Eggs, Flea eggs, Flea larvae, Adults
Animal Type
Dogs
Treatment Type
Treatment, Prevention
Supply Duration
4 month supply
Supply Amount
6 count
Weight Range
21-55 lbs
Breed Restrictions
DO NOT USE ON CATS
Contains
Imidacloprid, Pyriproxyfen
Free Of
Fragrance
Package Type
Box
Scent
Fragrance-free

Questions and answers

Is Advantage II worth it over a chewable flea pill?
Advantage II is usually cheaper per month and also kills flea eggs and larvae on the dog. Oral pills may suit dogs that hate topical liquids, but many require a prescription. Pick based on whether your dog tolerates a spot-on treatment.
How is it different from Advantage (without II)?
Original Advantage contains only imidacloprid and kills adult fleas. Advantage II adds pyriproxyfen, which stops eggs and larvae from developing, so it also interrupts the life cycle.
Does it kill ticks?
No. Advantage II targets fleas only. If ticks are a concern, you need a separate tick product or a combination treatment.
Can I use it on my cat?
No. The label says do not use on cats, and the dog formula can be toxic to them. Keep treated dogs away from cats until the product has dried.
How soon can my dog swim or get bathed after applying it?
Wait 24 hours. After that the treatment is waterproof and normal bathing and swimming won't wash it off.
When is the price lowest?
Multi-dose boxes like the 6-count usually cost less per dose than single packs. The current best price is $50.99 at Chewy.com as of November 4, 2026, so compare per-dose cost across the three stores listing it.
Where is the Elanco Advantage II Flea Treatment for Dogs cheapest?
At Chewy.com, for $50.99, as of our latest check.
Where can I buy the Elanco Advantage II Flea Treatment for Dogs?
3 stores we checked sell it, including Walmart, Chewy.com, PetSmart.