This book is Book 6 in the 100 Essential Medical Papers series. It selects 105 landmark studies that have shaped the history of anorexia nervosa and eating-disorder research, and it explains their key findings in a clear and accessible way.
It treats anorexia nervosa as a complex illness that extends beyond psychiatry. The topics include life-threatening medical complications, refeeding syndrome, suicide risk, family dynamics, comorbid obsessive-compulsive disorder and autism spectrum disorder, and genetic, neurological and metabolic factors.
The studies include randomized controlled trials of Family-Based Treatment for adolescent AN, the StRONG trial on refeeding, and ANTOP, which compares major psychotherapies for adults. They also include a large randomized trial of olanzapine, meta-analyses on mortality in eating disorders, and genome-wide association studies that helped redefine anorexia nervosa as a "metabo-psychiatric disorder."
- Author
- Medical Evidence 100 Editorial Team
- Series
- 100 Essential Medical Papers, Book 6
- Papers covered
- 105 landmark studies
- Subject
- Anorexia nervosa
- Diagnosis topics
- Diagnosis, epidemiology, long-term outcomes, atypical anorexia nervosa, severe and enduring anorexia nervosa (SE-AN)
- Medical topics
- Mortality, suicide and self-harm; cardiovascular, kidney and electrolyte, endocrine and bone complications; pregnancy; refeeding syndrome and nutritional rehabilitation
- Treatment topics
- Family-Based Treatment (FBT), CBT-E, MANTRA, SSCM, olanzapine and SSRIs, virtual reality, Cognitive Remediation Therapy (CRT), Deep Brain Stimulation (DBS)
- Comorbidity topics
- Autism spectrum disorder, OCD, depression, PTSD
- Other topics
- Compulsory treatment, palliative care and "terminal anorexia nervosa"; healthcare disparities, barriers to treatment, health economics; GWAS, neuroimaging, cognition, gut microbiome, multi-omics
- Intended readers
- Physicians, psychologists, nurses, dietitians, clinical psychologists, medical students, residents