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Neosporin + Lidocaine Antibiotic Ointment vs Neosporin Original Antibiotic Ointment

Buy Neosporin Original if you want plain infection protection at the lowest price: $4.98 at Lowe's as of November 7, 2026, versus $8.28 at Walmart for the + Lidocaine tube. Buy the + Lidocaine version if numbing a painful cut, scrape or minor burn matters more than the $3.30 difference. Both are 0.5 oz triple-antibiotic ointments from the same brand, so the real choice is pain relief versus price.

Today the Neosporin Original Antibiotic Ointment costs $3.51 less at its best price.

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Neosporin
Neosporin + Lidocaine Pain Relieving Antibiotic

Neosporin + Lidocaine Antibiotic Ointment

Neosporin + Lidocaine Pain Relieving Antibiotic

4.8(684 ratings)
$8.49at AmazonObserved at 7:52 AM
See all prices and details
Visit Amazon

Choose the Neosporin + Lidocaine if you are treating a painful minor cut, scrape or burn and want fast-acting lidocaine to numb it while the antibiotics prevent infection.

Pros
  • Lidocaine numbs painful minor cuts, scrapes and burns
  • Same triple-antibiotic infection protection as Original
  • Highest rating in this pair, 4.8 from 684 ratings
  • Works for minor burn care, not just cuts
Cons
  • Costs $3.30 more per 0.5 oz tube
  • Lidocaine can sting or irritate sensitive skin
  • No scar-minimizing claim
  • Not for children under 2 without a doctor
Neosporin
Neosporin Original Antibiotic Ointment, 0.5 oz

Neosporin Original Antibiotic Ointment

Neosporin Original Antibiotic Ointment, 0.5 oz

4.6(424 ratings)
$4.98at Lowe'sObserved at 9:00 AM
See all prices and details
Visit Lowe's

Store links may earn us a commission. Price via Klarna.

Choose the Neosporin Original if you want the standard triple-antibiotic ointment for everyday first aid and would rather pay $4.98 than $8.28.

Pros
  • Lowest price: $4.98 for 0.5 oz
  • Kills 99.9% of germs in 15 minutes in lab studies
  • HeliDerm Technology supports healing and helps minimize scars
  • The standard tube most first aid kits carry
Cons
  • No pain relief; application can sting an open wound
  • Lower rating than the + Lidocaine version
  • Same neomycin allergy risk as the other tube
  • Small 0.5 oz tube runs out fast on larger wounds

What separates them

Neosporin + Lidocaine Antibiotic OintmentNeosporin Original Antibiotic Ointment
Price (0.5 oz)$8.28 at Walmart as of November 7, 2026$4.98 at Lowe's as of November 7, 2026
Pain reliefContains lidocaine for maximum-strength numbingNo numbing agent
AntibioticsBacitracin zinc, neomycin sulfate, polymyxin B sulfateBacitracin zinc, neomycin sulfate, polymyxin B sulfate
Infection protection24 hours24 hours; kills 99.9% of germs in 15 minutes in lab studies
Scar appearanceNot claimedHelps minimize the appearance of scars; HeliDerm Technology
Rating4.8 out of 5 from 684 ratings4.6 out of 5 from 424 ratings
Stores stocking it new7 stores6 stores
Best forPainful wounds and minor burnsRoutine cuts, scrapes and first aid kits

Price history

  • Neosporin + Lidocaine Antibiotic Ointment: lowest $8.49 on Nov 7 at Target.
  • Neosporin Original Antibiotic Ointment: lowest $4.88 on Nov 7 at Walmart.

Prices at every store

Neosporin + Lidocaine Antibiotic Ointment

  • TargetNew

    In stock

    $8.49+ $5.99 shippingObserved at 9:00 AM
    Visit Target
  • WalgreensNew

    In stock

    $8.99+ $5.99 shippingObserved at 9:00 AM
    Visit Walgreens
  • Walgreens.comNew

    In stock

    $8.99+ $5.99 shippingObserved at 7:51 AM
    Visit Walgreens.com
  • AmazonNew

    Availability unknown

    As an Amazon Associate, Deal.ai earns from qualifying purchases.

    $8.49Observed at 7:52 AM
    Visit Amazon

Also available at

  • CVS PharmacyCheck price at CVS Pharmacy
  • WalmartCheck price at Walmart

Store links may earn us a commission. Some prices via Klarna.

All 7 stores and price history →

Neosporin Original Antibiotic Ointment

  • Lowe'sNew

    In stock

    $4.98Observed at 9:00 AM
    Visit Lowe's
  • Blain's Farm & FleetNew

    In stock

    $4.99Observed at 9:00 AM
    Visit Blain's Farm & Fleet
  • WalmartNew

    In stock

    $4.88+ $6.99 shippingObserved at 7:51 AM
    Visit Walmart
  • TargetNew

    In stock

    $4.99+ $10.99 shippingObserved at 7:51 AM
    Visit Target

Also available at

  • CVS PharmacyCheck price at CVS Pharmacy
  • HerbsproCheck price at Herbspro
  • Walgreens.comCheck price at Walgreens.com

Store links may earn us a commission. Some prices via Klarna.

Specs compared

SpecNeosporin + Lidocaine Antibiotic OintmentNeosporin Original Antibiotic Ointment
multipack_quantity11
colorOtherOther
size0.5 oz0.5 oz
TypePain & Fever—
Active SubstanceNone—
Weight/pack. (oz)0.5—
Dosage FormOintment—
Over-the-counter medicine typePain Relief—
Health concernPain Relief—
BrandNeosporin—
Product lineDual Action—
Age groupAdult—
Show all 31 specsShow fewer specs
SpecNeosporin + Lidocaine Antibiotic OintmentNeosporin Original Antibiotic Ointment
FormOintment—
Symptomspain relief—
Required storage conditionAmbient Storage—
Active ingredient nameBacitracin Zinc—
ManufacturerJohnson & Johnson—
Inactive ingredientsInactive Ingredients—
Product net content parent0.5 Ounces—
Net content statement0.5oz/14.2g—
Product net content uomOunce—

What reviewers say

Neosporin + Lidocaine Antibiotic Ointment

  • 4.8 / 5684 ratings

Users rate it highly for effectiveness and pain relief. Many mention it stings less than plain Neosporin and helps wounds heal quickly. Some report skin irritation or allergic reactions.

What people mention
  • Pain reliefPraisedUsers say the lidocaine numbs pain fast.
  • HealingPraisedMany report wounds heal quickly with no infection.
  • Allergic reactionCriticisedA few users developed a rash or itching after use.
  • StingingMixedSome feel a brief sting when applying, others don't.

Neosporin Original Antibiotic Ointment

  • 4.6 / 5424 ratings

Rated 4.6 out of 5 from 424 ratings, buyers treat it as a dependable staple for minor wounds. Complaints center on the greasy texture and skin reactions in people sensitive to neomycin.

What people mention
  • HealingPraisedBuyers say minor cuts and scrapes clear up fast with it.
  • TextureCriticisedUsers find the ointment greasy and sticky until a bandage goes over it.
  • Skin reactionCriticisedA few buyers report redness or itching, consistent with neomycin sensitivity.
  • ValueMixed

Questions and answers

Which is better for a painful cut or burn?
The + Lidocaine version. It adds lidocaine for numbing on top of the same triple-antibiotic infection protection, so it suits painful cuts, scrapes and minor burns better than Original.
Is the + Lidocaine version worth the extra $3.30?
Only if pain relief matters to you. The antibiotics are identical, so you are paying $8.28 instead of $4.98 for the numbing agent alone.
Do they prevent infection the same way?
Yes. Both use bacitracin zinc, neomycin sulfate and polymyxin B sulfate and claim 24-hour infection protection. Original also states it kills 99.9% of germs in 15 minutes in lab studies.
Which helps with scars?
Original. It claims HeliDerm Technology and helps minimize the appearance of scars; the + Lidocaine version makes no scar claim.
Can I use either on a child?
Both are adult-labeled ointments. Ask a doctor before using either on children under 2, and check for neomycin allergy, which applies to both tubes.
How often do I apply them?
Both are applied a small amount at a time, one to three times daily, after cleaning the wound. Cover with a bandage for extra protection.

More comparisons

  • Neosporin + Lidocaine Pain Relieving Antibiotic vs Neosporin + Pain Relief First Aid Ointment
  • Neosporin Original Antibiotic Ointment, 0.5 oz vs Neosporin + Pain Relief First Aid Ointment
All 6 stores and price history →
Items included
1 Tube of Antibiotic Ointment
—
Retail packagingSingle Piece—
GenderUnisex—
Active Ingredientbacitracin zinc, neomycin sulfate, polymyxin B …—
Treatment TypeBurn care—
ConditionMinor burns—
Application MethodOintment—
Application Frequency1-3 times daily—
Ingredient ListPetrolatum, Zinc, bacitracin zinc, neomycin sul…—
Container TypeTube—
Some feel the 0.5 oz tube is small for what it costs.