Which is better for a burn?

Neosporin + Pain Relief. It adds a numbing ingredient that eases the sting of minor burns, while Original only fights infection.

Is the + Pain Relief version worth the extra cost?

If the wound hurts, yes. It costs $9.99 at Amazon versus $4.98 for Original at Lowe's as of November 7, 2026, but you get pain relief and twice the volume.

Can I use either on a child?

Both are for minor cuts, scrapes and burns, but ask a doctor before using either on young children, and avoid the pain-relief version if your child reacts to numbing ingredients.

The + Pain Relief tube is 1 oz versus 0.5 oz for Original, so it lasts about twice as long at the same application rate. Both should be replaced when expired.

Do they work the same against infection?

Yes. Both use neomycin, bacitracin and polymyxin B, and Original's label claims it kills 99.9% of germs in as little as 15 minutes in lab studies.

Which is better for scars?

Original. Neosporin markets HeliDerm Technology to keep the wound hydrated and minimize the appearance of scars; the + Pain Relief label makes no scar claim.

Neosporin Original Antibiotic Ointment vs Neosporin + Pain Relief Ointment

Buy Neosporin Original if you want the cheapest, simplest infection protection for minor cuts and scrapes. Buy Neosporin + Pain Relief if the wound stings or you want lidocaine-style numbing on burns and scrapes, and you don't mind paying more. On November 7, 2026, Original is $4.98 for 0.5 oz at Lowe's, while + Pain Relief is $9.99 at Amazon for a 1 oz tube (listed as a 3-piece pack). Per ounce, Original is the better value; + Pain Relief buys comfort.

Today the Neosporin Original Antibiotic Ointment costs $5.01 less at its best price.

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