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Selegiline Tablets for Dogs, 5-mg

Selegiline Tablets for Dogs, 5-mg

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$59.49at AmazonObserved at 3:51 PM

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Our take on the Selegiline Tablets for Dogs, 5-mg

Selegiline is a prescription MAO-B inhibitor given to older dogs to slow signs of canine cognitive dysfunction, such as confusion, disorientation, house soiling and disrupted sleep. It is also used for some behavioral problems and, in some cases, pituitary-dependent Cushing's disease. It is a daily oral capsule, usually 5 mg for small dogs, and takes several weeks to show effect. The best new price is $59.49 at Amazon as of November 4, 2026, and only one store lists it new, so there is no real price spread to compare.

Best for
Senior dogs showing cognitive decline
Dogs with vet-diagnosed behavioral issues
Owners managing a long-term daily prescription
Small dogs on a 5 mg dose
Pros
  • Targets age-related cognitive decline, not just symptoms
  • Once-daily oral dosing is easy to give
  • Generic versions keep cost lower than brand Anipryl
  • Well studied in veterinary use for senior dogs
Cons
  • Prescription required; not available over the counter
  • Takes 4 to 8 weeks before improvement shows
  • Not safe with certain drugs, including some antidepressants and flea/tick products
  • Non-returnable and non-refundable once dispensed
  • Only one store lists it, so price shopping is limited

Selegiline Tablets for Dogs, 5-mg prices at every store

  • AmazonNew

    Availability unknown

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    $59.49Observed at 3:51 PM
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Also available at

  • HardyPawCheck price at HardyPaw

Selegiline Tablets for Dogs, 5-mg price history

Lowest price we've seen: $30.00 on Nov 4. Tracked across 2 stores since Nov 4.

What reviewers say

Owners of senior dogs often report gradual improvement in awareness and interaction after several weeks, though results vary and some dogs show little change. Veterinarians generally view it as a reasonable first-line option for cognitive dysfunction with a mild side-effect profile.

Pros
  • Noticeable improvement in older dogs' alertness
  • Few side effects for most dogs
  • Easy once-daily capsule
Cons
  • Slow onset; some owners see no change
  • Vomiting or restlessness in a minority of dogs
  • Cost adds up for long-term use

About the Selegiline Tablets for Dogs, 5-mg

Selegiline Tablets for Dogs | Vet Prescribed

Selegiline Tablets for Dogs are some of the most popular veterinary medicine solutions widely used by vets and pet owners alike. They are particularly targeted for aging dogs suffering from disorders such as CDS or Cushing's syndrome and others of the hormonal type as well. It is absorbed efficiently in the dog and works wonderfully as a treatment form for taking trip to the quality of life to the next level. This is most often prescribed when the dog exhibits the typical signs of confusion, disorientation, depression during sleeps and changes in activity.

Prescription items are NON-RETURNABLE and NON-REFUNDABLE.

NOTE: For generic medications, the picture displayed may not depict the actual product. Generic medications may vary from one order to the next by size, color, and shape depending on the manufacturer. Please note product may arrive in a Hardy Paw Pharmacy vial.

Key Benefits:

Supports cognitive function - aids in memory, awareness and behavior of aging dogs

Canine Cognitive Dysfunction - Helps to reduce confusion and disorientation

Dopamine Regulation – Enhances brain chemistry for better mental performance

Convenient Oral Tablet – Easy daily administration

Veterinary Prescribed Treatment – Trusted solution for senior dog care

For which conditions is Selegiline used in the treatment of dogs?

It is given to treat canine cognitive dysfunction (equivalent to dementia) and in some dogs perhaps to combat some forms of Cushing's.

Is a prescription needed for Selegiline Tablets?

Indeed Selegiline is prescribed medicine and must be given by a veterinarian licensed.

How it works

This drug elevates the levels of a messenger chemical of the nervous system called dopamine. Enhanced dopamine levels improve a number of cognitive abilities. Managing Cushing's Disease has generally been focused on suppressing the adrenal glands production and excretion of cortisone, with significant potential for side effects. Selegiline has enabled the possibility of a direct suppression of the pituitary gland.

Dosage & Administration:

Administer this medication to your pet as directed by your veterinarian. Make sure get it to your animal with fresh water. Ask the advice of pharmacist or veterinarian. Please keep the selegiline in original container. Keep in dry place and room temperature. Avoid exposure to heat. Never expose to heat. Do not allow children and animals to come into contact.

Dogs (when referring to the disorder called cognitive dysfunction):

For treating CCD, recommended dosage is generally 0.2mg- 0.45 mg per lb (0.09- 0.2 mg/kg) of the pet's body weight. It can be a period of over a month before one will notice any affect.

Dogs (Cushing's disease):

The standard initial dose for treatment of the Cushings disease is 0.45mgs/lb of the animal's body weight given once every 24 hours (in the morning). If after two months there is no improvement in the condition, the dose can be increased to 0.9mgs/lb of body weight. If no response is achieved after one month it is recommended to reevaluate the animal.

Canine cognitive dysfunction is also treated with selegiline.

Do not administer an increased dose of this medication without prior consent of your veterinarian.

Specifications

Dosage
5
Dosage Unit
mg
Species
Dogs
Age
Senior
Active Ingredients
Selegiline
Administration Method
Oral (Capsules)
Formulation
Capsules
Product Size

Questions and answers

Is selegiline worth it for an older dog?
For a dog with diagnosed cognitive dysfunction, it is one of the few drugs shown to help, and many owners see better awareness and sleep within a few weeks. It will not reverse aging, and response varies by dog.
How long until it works?
Most vets expect 4 to 8 weeks of daily dosing before judging results. Give it consistently and report changes to your vet.
What drugs should not be combined with selegiline?
Avoid combining it with other MAO inhibitors, SSRIs, tramadol or amitraz-based flea and tick products unless your vet approves. Ask your vet to review every medication and supplement your dog takes.
What's in the bottle?
The bottle contains selegiline hydrochloride capsules in the strength your vet prescribed. Generic manufacturers vary, so capsule appearance may differ between orders.
Is this the same as Anipryl?
Yes, selegiline is the active ingredient in Anipryl. Generic versions are typically cheaper and work the same at the same dose.
When is the price lowest?
Only one store lists it new, at $59.49 at Amazon as of November 4, 2026, so there is little price competition. Compare that against your vet's in-clinic price.
Where is the Selegiline Tablets for Dogs, 5-mg cheapest?
At Amazon, for $59.49, as of our latest check.
Where can I buy the Selegiline Tablets for Dogs, 5-mg?
2 stores we checked sell it, including Amazon, HardyPaw.

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    Selegiline
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5 mg
Ingredients
Selegiline hydrochloride
Manufacturer
Generic (brand may vary)
Packaging Type
Bottle