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Zoetis
Zoetis Simparica Trio Chewable Tablets for Dogs

Zoetis Simparica Trio Chewable Tablets for Dogs

Best price now

$39.47at AmazonChecked 7 h ago

64% under what the other stores charge

Compared across 4 stores. Prices are checked against each store and labelled with when. As an Amazon Associate, Deal.ai earns from qualifying purchases.

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Price facts

  • Lowest price today: $39.47 at Amazon (checked Nov 11, 2026).
  • Checked at 4 stores.

Our take on the Zoetis Simparica Trio Chewable Tablets for Dogs

Simparica Trio is a once-monthly liver-flavored chew that combines flea, tick, heartworm, roundworm, hookworm and flea tapeworm protection in one dose. It was the first combination preventive FDA-approved to kill six tick species, including the deer tick that can carry Lyme disease, and it starts killing fleas within 4 hours. It suits owners who want a single monthly chew instead of separate flea, tick and heartworm products, and it is approved for puppies from 8 weeks and 2.8 pounds. Owners report dogs usually take it like a treat, though some dogs refuse it and a few still find fleas or ticks in peak season.

Best forOwners who want one monthly chew instead of separate flea, tick and heartworm prPuppies from 8 weeks and 2.8 poundsDogs in tick-heavy or wooded areasMulti-dog households on a monthly routine
Pros
  • One monthly chew covers fleas, ticks, heartworm, roundworms, hookworms and flea tapeworm
  • Kills fleas fast and before they lay eggs
  • FDA-approved for six tick species, including deer ticks
  • Liver-flavored chew that most dogs eat willingly
  • Can be given with or without food
Cons
  • Some dogs refuse the chew and it has to be crushed or hidden in food
  • A few owners still find fleas or ticks in summer
  • Prescription required, so a vet visit comes first
  • Not for dogs under 2.8 pounds or under 8 weeks

Zoetis Simparica Trio Chewable Tablets for Dogs prices at every store

  • Chewy.comNew

    In stock

    $39.47+ $4.95 shippingChecked 7 h ago
    Visit Chewy.com
  • Allivet Pet PharmacyNew

    In stock

    $108.73Free shippingChecked 7 h ago
    Visit Allivet Pet Pharmacy
  • Tractor Supply CompanyNew

    In stock

    $108.73+ $6.95 shippingChecked 7 h ago
    Visit Tractor Supply Company
  • AmazonNew

    Availability unknown

    As an Amazon Associate, Deal.ai earns from qualifying purchases.

    $39.47Checked 7 h ago
    Visit Amazon

Zoetis Simparica Trio Chewable Tablets for Dogs price history

Lowest price we've seen: $39.47 on Nov 11 at Chewy.com. Tracked across 4 stores since Nov 11.

What reviewers say

Owners mostly report that Simparica Trio keeps dogs free of fleas and ticks, including in wooded and field areas, and that most dogs take the chew easily. Complaints center on picky dogs refusing it and occasional fleas or ticks still showing up in peak season.

What people mention
  • Flea and tick controlPraisedOwners say it keeps dogs clear of fleas and ticks, including in wooded and field areas.
  • Ease of dosingMixedMost dogs eat the liver-flavored chew like a treat, but some refuse it and owners have to crush or hide it.
  • Side effectsPraisedMany reviewers report no side effects in their dogs.
  • Breakthrough fleasCriticisedA few owners still find ticks or fleas on their dogs occasionally in summer.
  • CostCriticisedOne reviewer finds the monthly chew very expensive.

From Allivet Pet Pharmacy

  • First FDA-approved combo preventative of its kind: one monthly chew protects against fleas, ticks and heartworms
  • #1 vet-prescribed combo preventative
  • Kills fleas before they can lay eggs; starts killing fleas within 4 hours with 100% effectiveness in 8 hours
  • First combination preventative FDA-approved to kill six types of ticks, including the deer tick that may carry Lyme infections
  • Treats and controls roundworms and hookworms; prevents flea tapeworms by killing fleas
  • Liver-flavored chew given once a month, with or without food; 9 out of 10 dogs voluntarily consumed it in a study
Sizes
2.8-5.5 lbs Gold, 11.1-22 lbs Caramel, 22.1-44 lbs Blue, 44.1-88 lbs Green, 88.1-132 lbs Brown
Materials
Active ingredients: Sarolaner, Moxidectin, Pyrantel
Sizing
Dose by body weight; approved for dogs 8 weeks and older weighing at least 2.8 lbs.
Guarantee
100% satisfaction guarantee on protection; call Zoetis' medical support team at 1-888-ZOETIS1 if protection seems insufficient.
Returns
Unable to accept returned prescription drugs due to federal and state laws.
Shipping
Usually shipped in 1-3 business days; free 1-3 day standard shipping on qualifying orders (excludes expedited, Hawaii and Alaska).
Packs
Sold as 1 Month, 3 Month, 6 Month or 12 Month Supply
Size chart
Body WeightSarolaner per Tablet (mgMoxidectin per Tablet (mPyrantel per Tablet (mg)Number of Tablets Admini
2.8 to 5.5 lbs3.00.0612.51
5.5 to 11 lbs6.00.12251
11-22 lbs120.24501
22-44 lbs240.481001
44-88 lbs480.962001
88-132 lbs721.443001

About the Zoetis Simparica Trio Chewable Tablets for Dogs

Simparica Trio is a once-monthly, liver-flavored chewable tablet for dogs. It protects against heartworm disease, ticks, fleas, flea tapeworms, roundworms, and hookworms. The active ingredients are sarolaner, moxidectin, and pyrantel.

It kills fleas before they can lay eggs. It starts killing fleas within 4 hours, with 100% effectiveness in 8 hours. It was the first combination preventative FDA-approved to kill six types of ticks, including the deer tick that may carry Lyme infections. It treats and controls roundworms and hookworms, and it prevents flea tapeworms by killing fleas.

The chew can be given with or without food. Dose by body weight. It is approved for puppies 8 weeks and older weighing at least 2.8 pounds. In a study, 9 out of 10 dogs voluntarily consumed it.

Animal
Dog
Active ingredients
Sarolaner, moxidectin, pyrantel
Form
Liver-flavored chewable tablet
Dosing
Once a month, with or without food
Minimum age
8 weeks
Minimum weight
2.8 lbs
Protects against
Heartworm, ticks, fleas, flea tapeworms, roundworms, hookworms
2.8-5.5 lbs
Gold
11.1-22 lbs
Caramel
22.1-44 lbs
Blue

What buyers say

Buyers like
  • One monthly pill covers heartworm, fleas and ticks
  • No side effects reported by many reviewers
  • Dogs take it easily, often like a treat
  • Keeps dogs free of fleas and ticks, including in wooded or field areas
  • Convenient AutoShip and easy ordering process
  • Trusted for years across multiple pets
Buyers complain about
  • Some dogs refuse the chew and it must be crushed or hidden in food
  • A few reviewers still find ticks or fleas occasionally in summer
  • One reviewer finds it very expensive

Specifications

Animal
Dog

Questions and answers

What does Simparica Trio protect against?
One monthly chew protects against fleas, ticks, heartworm disease, roundworms, hookworms and flea tapeworms. It kills fleas before they can lay eggs and is approved for six tick species, including deer ticks.
How old does my dog need to be for Simparica Trio?
It is approved for puppies as young as 8 weeks old that weigh at least 2.8 pounds. Dogs outside that range need a different product, so ask your vet.
How fast does it start working?
It starts killing fleas within 4 hours, with 100% effectiveness in 8 hours in studies. It is given once a month, with or without food.
Do dogs actually eat the chew?
In a study, 9 out of 10 dogs ate it voluntarily. Some owners still report picky dogs refusing it, in which case it can be crushed or hidden in food.
Is Simparica Trio the same as giving separate flea, tick and heartworm products?
It combines all three in one chew, which is simpler than separate products. It also covers roundworms, hookworms and flea tapeworms, which many standalone flea and heartworm products do not.
Do I need a prescription?
Yes. Simparica Trio is a prescription product, so your vet must approve it for your dog before you can buy it.
Where is the Zoetis Simparica Trio Chewable Tablets for Dogs cheapest?
At Amazon, for $39.47, 64% under what the other stores charge, as of our latest check.
What do buyers say about the Zoetis Simparica Trio Chewable Tablets for Dogs?
Buyers like: One monthly pill covers heartworm, fleas and ticks; No side effects reported by many reviewers; Dogs take it easily, often like a treat. Common complaints: Some dogs refuse the chew and it must be crushed or hidden in food; A few reviewers still find ticks or fleas occasionally in summer.
Where can I buy the Zoetis Simparica Trio Chewable Tablets for Dogs?
4 stores we checked sell it, including Chewy.com, Allivet Pet Pharmacy, Tractor Supply Company, Amazon.

Stores we've priced the Zoetis Simparica Trio Chewable Tablets for Dogs at

  • Chewy.com deals and prices
  • Tractor Supply Company deals and prices

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