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Simparica Trio is a once-a-month prescription chew from Zoetis that combines three active ingredients in one dose: sarolaner for fleas and ticks, moxidectin for heartworm and hookworm, and pyrantel for roundworm and hookworm. It is FDA-approved to kill deer ticks, which reduces the risk of the infections that cause Lyme disease. It is the first product of its kind to cover fleas, ticks, heartworm and intestinal worms in a single monthly chew, so it replaces a separate flea/tick product and a heartworm preventive. It suits owners who want one monthly dose instead of several, and puppies from 8 weeks and 2.8 lbs can take it.
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Lowest price we've seen: $38.90 on Nov 15 at Allivet Pet Pharmacy. Tracked across 3 stores since Nov 15.
Owners generally report that dogs take the liver-flavored chew readily and that it replaces two or three separate products. Complaints center on dogs that refuse the taste and on digestive upset in some dogs.
Simparica Trio is a once-a-month chewable tablet for dogs. It has a liver flavor and is given by mouth. It combines three ingredients: sarolaner, moxidectin and pyrantel.
It protects dogs against heartworm disease, ticks and fleas, roundworms and hookworms. It is FDA-approved to block infections that may cause Lyme disease by killing deer ticks. Fleas are killed within 4 to 8 hours after treatment, and 98.9% of pre-existing paralysis ticks are killed within 24 hours.
Dosing is by weight, and a veterinarian sets the dose and course of treatment. It is safe for puppies as young as 8 weeks old that weigh at least 2.8 lbs. Dogs should be tested for existing heartworm infection before they are given it, because it is not effective against adult heartworms. It is not for use in humans.
