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Bayer
Bayer Advantage II Liquid Dog Flea Drops Imidacloprid/Pyriproxyfen 4

Bayer Advantage II Liquid Dog Flea Drops Imidacloprid/Pyriproxyfen 4

4.4(942 ratings)

Best price now

$48.44at WalmartChecked 5 h ago

Compared across 6 stores. Prices are checked against each store and labelled with when.

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Price facts

  • Lowest price today: $48.44 at Walmart (checked Nov 11, 2026).
  • Checked at 6 stores.

Our take on the Bayer Advantage II Liquid Dog Flea Drops Imidacloprid/Pyriproxyfen 4

Advantage II is a monthly topical flea treatment for dogs weighing 21 to 55 lbs. It combines imidacloprid, which kills adult fleas, with pyriproxyfen, an insect growth regulator that stops eggs and larvae from developing. It also treats chewing lice. Unlike oral chewables such as NexGard or Bravecto, it needs no prescription and works on contact, so fleas die without biting. It does not kill ticks, which is the main reason owners switch to a tick product.

Best forOwners of medium to large dogs with a flea problemHouseholds that prefer a topical over an oral chewDogs that refuse chewable tabletsMulti-dog homes treating fleas on contact
Pros
  • Kills adult fleas, eggs and larvae, breaking the life cycle
  • Starts killing fleas within 12 hours
  • Also treats chewing lice
  • No prescription needed
  • Waterproof after it dries, so swimming and bathing are fine
Cons
  • Does not kill ticks
  • Monthly reapplication needed; it is not a long-acting chew
  • Some dogs itch or get temporary irritation at the application site
  • Greasy spot and a strong smell right after applying
  • Flea resistance to imidacloprid is reported in some areas

Bayer Advantage II Liquid Dog Flea Drops Imidacloprid/Pyriproxyfen 4 prices at every store

  • WalmartNew

    In stock

    $48.44Free shippingChecked 5 h ago
    Visit Walmart
  • WalmartNew

    In stock

    $50.99Free shippingChecked 5 h ago
    Visit Walmart
  • ChewyNew

    In stock

    $50.99Free shippingChecked 5 h ago
    Visit Chewy
  • PetsmartNew

    In stock

    $52.99+ $5.99 shippingChecked 5 h ago
    Visit Petsmart
  • Ace HardwareNew

    In stock

    $64.99Free shippingChecked 5 h ago
    Visit Ace Hardware
  • PetCareRxNew

    In stock

    $67.99Free shippingChecked 5 h ago
    Visit PetCareRx

Store links may earn us a commission. Some prices via Klarna.

Bayer Advantage II Liquid Dog Flea Drops Imidacloprid/Pyriproxyfen 4 price history

Lowest price we've seen: $50.99 on Nov 11 at Walmart. Tracked across 5 stores since Nov 11.

What reviewers say

  • 4.4 / 5942 ratings

Owners rate it highly and many report fleas gone within a day and no reinfestation with monthly use. Complaints center on application-site irritation, the greasy residue and the lack of tick coverage.

What people mention
  • EffectivenessPraisedOwners say fleas are gone within a day and stay gone with monthly dosing.
  • ApplicationMixedEasy to squeeze on, but it leaves a greasy patch and a strong smell.
  • Skin irritationCriticisedA minority report itching, redness or hair loss where the drops go.
  • Tick coverageCriticisedIt kills fleas and lice but not ticks, so tick-prone dogs need another product.
  • ValuePraisedOwners find the multi-pack convenient and cheaper than a vet visit for the same active ingredients.

About the Bayer Advantage II Liquid Dog Flea Drops Imidacloprid/Pyriproxyfen 4

Dog weight
21-55 lb
Pack size
4-pack

Specifications

Food Type
SupplementsSource
Dog Size
Medium (11-25kg), Maxi (26-44kg)Source
No. of Packs (pack)
4Source
Color
Red, WhiteSource

Questions and answers

How often do I apply it?
Once a month. Each pack holds four monthly doses, so one pack covers four months for a single dog.
Does it kill ticks?
No. It kills fleas at all life stages and chewing lice. For ticks, use a product labeled for ticks such as a permethrin collar or an isoxazoline chewable.
Can I bathe my dog after applying it?
Yes, once the solution has dried, usually within a few hours. It stays effective through bathing and swimming.
What weight range does this pack fit?
Dogs from 21 to 55 lbs. Smaller dogs need the 11 to 20 lb version, and puppies must be at least 7 weeks old.
How does it compare with a chewable like NexGard?
The chewable also kills ticks and lasts a month with no residue. Advantage II is non-prescription, works on contact and suits dogs that will not take tablets, but it leaves a topical spot and skips ticks.
What is in the box?
Four single-dose applicator tubes of the 21 to 55 lb formula. No collar or comb is included.
Where is the Bayer Advantage II Liquid Dog Flea Drops Imidacloprid/Pyriproxyfen 4 cheapest?
At Walmart, for $48.44, as of our latest check.
What do buyers say about the Bayer Advantage II Liquid Dog Flea Drops Imidacloprid/Pyriproxyfen 4?
Rated 4.4 out of 5 from 942 ratings.
Where can I buy the Bayer Advantage II Liquid Dog Flea Drops Imidacloprid/Pyriproxyfen 4?
5 stores we checked sell it, including Walmart, Chewy, Petsmart, Ace Hardware, PetCareRx.

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Stores we've priced the Bayer Advantage II Liquid Dog Flea Drops Imidacloprid/Pyriproxyfen 4 at

  • Ace Hardware deals and prices
  • Walmart deals and prices

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