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Best flea treatments for dogs

Researched by Deal.ai's shopping agent across stores on November 4, 2026. Prices below are today's.

Top pick: NexGard PLUS — a monthly beef-flavored chew that kills fleas and ticks and also deworms (roundworms), so one tablet covers the three things dogs pick up most. No greasy spot-on, and it's labeled for puppies from 8 weeks. Best if your dog takes tablets easily and you want flea, tick and worm cover in one.

Who the others suit:

  • Bravecto (chew or topical) — if you'd rather dose every 12 weeks than monthly; the topical suits dogs that spit out chews.
  • Simparica / Simparica TRIO / Credelio Quattro — chewables for dogs that need broader parasite cover (TRIO and Quattro add heartworm and intestinal worms).
  • Revolution — a topical that also handles mites and heartworm; good for sensitive dogs or homes with cats.
  • K9 Advantix II / Advantix / Advantage II — budget spot-ons; Advantix repels mosquitoes and ticks too, but is toxic to cats, so skip it in cat households.
  • Flea & Tick Spot On — the cheapest basic fipronil option for a quick flea-only fix.

Whatever you choose, treat every pet in the house and wash bedding, or fleas keep coming back. Prescription options need your vet's OK.

The picks

  1. NexGard
    NexGard PLUS
    #1

    NexGard PLUS

    • Targeted Pests: Fleas, Roundworms, Ticks
    • Active Ingredient: Moxidectin, Afoxolaner, Pyrantel
    • Administration Method: Chewable tablet, Oral
    • Life Stage Age: Puppies as young as 8 weeks of age
    • Treatment Frequency: Monthly
    • Dosage Concentration: 75 mg Afoxolaner
    $115.19at Chewy.comObserved at 5:09 AMCompare 2 stores →
  2. Bravecto
    Bravecto Chews for Dogs
    #2

    Bravecto Chews for Dogs

    • Animal:

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Dog
  • Active ingredient: fluralaner
  • Minimum dose: 11.4 mg/lb (25 mg/kg) body weight
  • Dosing frequency: single dose every 12 weeks
  • Flea protection duration: 12 weeks
  • Tick protection duration: 12 weeks
  • $65.83at Bandana RxObserved at 5:11 AMCompare 2 stores →
  • Bravecto
    Bravecto for Dogs - 12-week dose (Rx)
    #3

    Bravecto for Dogs - 12-week dose (Rx)

    • Animal: Dog
    • Active ingredient: fluralaner
    • Form: topical solution
    • Minimum dose: 11.4 mg/lb (25 mg/kg) body weight
    • Fluralaner concentration: 280 mg
    • Dosing interval: every 12 weeks
    $80.99at AmazonObserved at 5:11 AMPrices and history →
  • Simparica
    Simparica TRIO Chewable Tablets for Dogs
    #4

    Simparica TRIO Chewable Tablets for Dogs

    • Animal: Dog
    • Minimum age: 8 weeks of age and older
    • Dosing frequency: once a month
    • Sarolaner dosage: 0.54 mg/lb (1.2 mg/kg)
    • Moxidectin dosage: 0.011 mg/lb (24 μg/kg)
    • Pyrantel dosage: 2.27 mg/lb (5 mg/kg)
    $234.77at AmazonObserved at 5:09 AMCompare 2 stores →
  • Credelio
    Credelio Quattro Chewable Tablets for Dogs
    #5

    Credelio Quattro Chewable Tablets for Dogs

    • Animal: Dog
    • Active ingredients: lotilaner, moxidectin, praziquantel, and pyrantel chewable tablets
    • Tablet form: flavored chewable tablets
    • Number of sizes: five sizes
    • Minimum lotilaner dose: 9 mg/lb (20 mg/kg)
    • Minimum moxidectin dose: 0.009 mg/lb (0.02 mg/kg)
    $217.15at AmazonObserved at 5:09 AMPrices and history →
  • Simparica
    Simparica Chewables for Dogs
    #6

    Simparica Chewables for Dogs

    • Animal: Dog
    • Active ingredient: sarolaner
    • Minimum dosage: 0.91 mg/lb (2 mg/kg)
    • Dosing frequency: once a month
    • Minimum age: over 6 months of age
    • Tablet strengths: 5, 10, 20, 40, 80, 120
    $29.04at Allivet Pet PharmacyObserved at 5:34 AMCompare 4 stores →
  • Revolution
    Revolution Topical Solution for Dogs
    #7

    Revolution Topical Solution for Dogs

    • Animal: Dog
    • Active ingredient: selamectin
    • Minimum dose: 2.7 mg/lb (6 mg/kg) of body weight
    • Minimum dog age: six weeks of age
    • Flea control duration: one month
    • Dose volume 5.1–10 lb: 0.25 mL
    $76.30at Heartland Veterinary Supply and PharmacyObserved at 5:09 AMCompare 3 stores →
  • K9 Advantix
    K9 Advantix II Flea and Tick Prevention for Dogs
    #8

    K9 Advantix II Flea and Tick Prevention for Dogs

    • Active ingredients: Imidacloprid - 8.80% Permethrin - 44.00% Pyriproxyfen - 0.44%
    • Application frequency: Apply on your pet once a month
    • Minimum dog age: 7 weeks of age or older
    • Minimum dog weight: 4 lbs
    • Package contents: 4 applicator tubes
    • Waterproof: Waterproof
    $19.97at WalmartObserved at 5:11 AMCompare 4 stores →
  • Advantix
    Advantix Dog 4 Month Topical Flea Treatment
    #9

    Advantix Dog 4 Month Topical Flea Treatment

    • Targeted Pests: Fleas, Mosquitoes, Ticks
    • Active Ingredient: Imidacloprid, Permethrin, Pyriproxyfen
    • Administration Method: Topical, Spot-on
    • Life Stage Age: Adult
    • Treatment Frequency: Monthly
    • Dosage Concentration: 0.44% (pyriproxyfen)
    $79.92at AmazonObserved at 5:09 AMPrices and history →
  • Advantage
    Advantage II for Dogs
    #10

    Advantage II for Dogs

    • Active ingredients: Imidacloprid - 9.10% Pyriproxyfen - 0.46%
    • Target pests: Adult Fleas, Flea Larvae, Flea Eggs
    • For use in: Cats & Kittens
    • Flea kill time: within 12 hours of application
    • Protection duration: up to one month
    • Waterproof: Waterproof
    $66.99at Revival Animal HealthObserved at 5:09 AMPrices and history →