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Frontline Plus is a monthly topical flea and tick treatment for dogs, applied to one spot between the shoulder blades. Its two active ingredients, fipronil and (S)-methoprene, kill adult fleas and also stop eggs and larvae from developing, which breaks the flea life cycle rather than just clearing live fleas. The formula collects in the dog's oil glands and keeps replenishing onto the skin, and it stays effective after swimming or bathing. It is approved for puppies from 8 weeks old weighing at least 5 pounds. Compared with chewable oral products it is slower to start and leaves a greasy spot for a day or two, but it covers the environment's flea stages and costs less than most prescription chewables. Owners rate it well overall, though some report fleas returning and complain about the applicator and the residue.
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Lowest price we've seen: $32.78 on Nov 11 at Petco.com; highest $34.89 on Nov 4; $40.98 now. Tracked across 27 stores since Nov 4.
With over 26,000 ratings averaging 4.2 out of 5, most owners say it keeps their dogs flea-free month after month and holds up through swimming and baths. Complaints center on fleas that survive or come back, the greasy residue and smell, and the applicator.
Frontline Plus for Dogs is a topical flea and tick treatment. It kills adult fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease. It contains fipronil and (S)-methoprene, which work together to break the flea life cycle and guard against further infestations.
The treatment is applied to a single point on the dog. It covers the entire body and deposits in the sebaceous glands, which act as a reservoir that continuously replenishes it on the coat. The formula is waterproof, so it keeps working if the dog gets wet, swims, or is bathed.
One dose each month protects against fleas and ticks for a full 30 days. It can be used on puppies 8 weeks and older that weigh 5 pounds or more. A separate Frontline Plus formula is made for cats and kittens 8 weeks and older that weigh 1.5 pounds or more.








