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Simparica Trio Chewable Tablet for Dogs vs Simparica Trio XL Chew for Dogs

These are the same drug, Simparica Trio, in two different dose sizes. The 11.1–22 lb six-pack suits small adult dogs and puppies from 8 weeks; the 88.1–132 lb version suits large dogs. Both are liver-flavored monthly chews that kill fleas fast and cover ticks, heartworm and intestinal worms. Owners consistently say dogs eat them willingly and that flea control is quick. The main practical difference is pack size and the prescription requirement, not the formula.

  • Choose the Simparica Trio 11.1–22 lbs 6-pack if your dog falls in that weight band and you want a full six months of protection in one box.
  • Choose the Simparica Trio 88.1–132 lbs if you have a large dog in that range and want the same protection in the matching dose.

Prices

  • Simparica Trio Chewable Tablet for Dogs: $40.05 at Amazon (last seen Nov 14)
  • Simparica Trio XL Chew for Dogs: $66.95 at 79Pets.com (last seen Nov 14)
  • Difference: the Simparica Trio Chewable Tablet for Dogs is $26.90 cheaper than the Simparica Trio XL Chew for Dogs at the latest prices (Nov 14)
Zoetis
Zoetis Simparica Trio Chewable Tablet 11.1-22 lbs 6 pcs

Simparica Trio Chewable Tablet for Dogs

Zoetis Simparica Trio Chewable Tablet 11.1-22 lbs 6 pcs

5(4 ratings)
$40.05at AmazonChecked 15 h ago
See all prices and details
Visit Amazon

Store links may earn us a commission. As an Amazon Associate, Deal.ai earns from qualifying purchases.

Pros
  • Six-month supply in one box
  • Kills fleas fast, 100% in 8 hours in studies
  • Covers heartworm, ticks, fleas and three intestinal worms
  • Liver chew most dogs take voluntarily
  • Approved from 8 weeks
Cons
  • Needs a vet prescription
  • Non-returnable once shipped
  • Wrong dose if your dog is outside 11.1–22 lbs
Zoetis
Simparica Trio For Dogs 88.1-132 lbs (40-60 kg)

Simparica Trio XL Chew for Dogs

Simparica Trio For Dogs 88.1-132 lbs (40-60 kg)

4.9(13 ratings)
$66.95at 79Pets.comChecked 14 h ago
See all prices and details
Visit 79Pets.com
Pros
  • Correct dose for large dogs
  • Same broad parasite coverage as the small-dog version
  • Rated 4.9 out of 5 by buyers
  • Chewable liver flavor is easy to give
  • Works with or without food
Cons
  • Only 3 chews per box
  • Needs a vet prescription
  • Some orders ship from abroad and take longer

What separates them

Simparica Trio Chewable Tablet for DogsSimparica Trio XL Chew for Dogs
Dog weight range11.1–22 lbs88.1–132 lbs (40–60 kg)
Supply in the box6 monthly chews3 monthly chews
Active ingredientsSarolaner, moxidectin, pyrantel (small-dog dose)Sarolaner 72 mg, moxidectin 1.44 mg, pyrantel 300 mg
Minimum age8 weeks, at the dose's minimum weight8 weeks, at least 2.8 lbs
Flea kill speedStarts within 4 hours, 100% in 8 hours in studiesWithin 4 to 8 hours
Tick coverageSix tick types including deer tickSame label; 98.9% of paralysis ticks killed in 24 hours
Dosing with foodWith or without foodWith or without food
PrescriptionRequires vet approval; non-returnableRequires vet approval

Price history

  • Simparica Trio Chewable Tablet for Dogs: lowest $40.05 on Nov 15 at Amazon.

Prices at every store

Simparica Trio Chewable Tablet for Dogs

  • Tractor Supply CoNew

    In stock

    $210.09Free shippingChecked 11 h ago
    Visit Tractor Supply Co
  • ChewyNew

    In stock

    $210.09Free shippingChecked 11 h ago
    Visit Chewy
  • BaxterBooNew

    In stock

    $210.09Checked 11 h ago
    Visit BaxterBoo
  • AmazonNew

    Availability unknown

    As an Amazon Associate, Deal.ai earns from qualifying purchases.

    $40.05Checked 15 h ago
    Visit Amazon

Store links may earn us a commission. Some prices via Klarna.

All 6 stores and price history →

Simparica Trio XL Chew for Dogs

  • 79Pets.comNew

    In stockReturn policy

    $66.95Checked 14 h ago
    Visit 79Pets.com
Prices and history →

Specs compared

SpecSimparica Trio Chewable Tablet for DogsSimparica Trio XL Chew for Dogs
Food TypeDog Chew—
IngredientsLiver, Beef—
No. of Packs (pack)6—
Age GroupAdult, Puppy—
Special DietsFur & Skin Care—
Minimum age—8 weeks of age
Administration frequency—one chew per month
Flea kill speed—within 4 to 8 hours after treatment
Flea re-infestation efficacy—35 days
Paralysis tick kill rate—98.9% of pre-existing paralysis ticks killed wi…
Form—Tasty liver flavoured chew
Sarolaner dosage—0.54 mg/lb (1.2 mg/kg)
Show all 16 specsShow fewer specs
SpecSimparica Trio Chewable Tablet for DogsSimparica Trio XL Chew for Dogs
Moxidectin dosage—0.011 mg/lb (24 μg/kg)
Pyrantel dosage—2.27 mg/lb (5 mg/kg)
Administration with food—with or without food
Weight range (XL)—40.1 – 60 kg

What reviewers say

Simparica Trio Chewable Tablet for Dogs

Owners and veterinarians generally rate Simparica Trio as a reliable, easy monthly all-in-one. The most common complaints are stomach upset in sensitive dogs and occasional refusal of the chew.

What people mention
  • ConveniencePraisedOwners like replacing separate flea, tick and heartworm products with a single monthly chew.
  • Stomach upsetCriticisedSome owners report vomiting or loose stools, especially in dogs with sensitive digestion.
  • PalatabilityMixedMost dogs take the liver and beef chew readily, but some refuse it or spit it out.
  • Flea controlPraisedUsers report fleas dying quickly and staying away with monthly dosing.

Simparica Trio XL Chew for Dogs

  • 4.9 / 513 ratings

Owners rate it 4.9 out of 5 and describe it as effective flea and tick protection that is easy to give as a chew.

What people mention
  • EffectivenessPraisedOwners say it works well against fleas and ticks.
  • Ease of givingPraisedThe liver-flavored chew is easy to give and dogs take it readily.
  • ValuePraisedBuyers feel the combined coverage is good value.

Questions and answers

Are these the same product?
Yes. Both are Simparica Trio; only the dose size and pack count differ. Pick the one that matches your dog's weight.
Which is better for a puppy?
Both are approved from 8 weeks, but only at the minimum weight for the dose. A puppy under 11.1 lbs needs a smaller dose than either of these.
Which lasts longer?
Each chew protects for one month. The 11.1–22 lb box covers six months; the large-dog box covers three.
Does my dog need a vet prescription?
Yes. Simparica Trio is prescription-only, so you will need your vet to approve the order.
Is the large-dog version worth stepping up to?
Only if your dog weighs 88.1–132 lbs. Giving a large-dog chew to a smaller dog overdoses it, so match the weight band.
What if my dog is between the two weight ranges?
Neither of these fits. Simparica Trio comes in intermediate sizes for dogs between 22 and 88 lbs.

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More comparisons

  • Simparica Trio Dog Chewable Tablets 2.8-5.5 lb 6 Treatments vs Zoetis Simparica Trio Chewable Tablet 11.1-22 lbs 6 pcs
  • Zoetis Simparica Trio Chewable Tablets for Dogs 88.1-132 lb 6 Month Supply vs Zoetis Simparica Trio Chewable Tablet 11.1-22 lbs 6 pcs
  • Simparica Trio Dog Chewable Tablets 2.8-5.5 lb 6 Treatments vs Simparica Trio For Dogs 88.1-132 lbs (40-60 kg)

Buying guides that pick them

  • Best flea, tick and heartworm prevention for dogs