StoreDeal.ai store
Shop
  • Deals
  • Deal checker
  • Black Friday
  • Buying guides
  • Brands
  • Stores
Travel
  • Flight deals
  • Hotel deals
Company
  • Research
  • Press
  • Use in AI assistants
  • Contact
  • deal.ai apps
Black Friday 2026
  • Walmart
  • Best Buy
  • Target
  • TVs
  • Laptops
  • Headphones
  • Apple
  • Gaming
  • Vacuums
  • Kitchen
  • Toys
  • Smartwatches
  • Tablets
  • Furniture
  • Mattresses
© Deal.ai Inc.·2222 Ponce de Leon Blvd, Miami, FL 33134·support@deal.ai
TermsPrivacy
Deal.ai › Compare

Simparica Trio Chewable Tablets for Dogs vs Simparica Trio Chewable Tablet for Dogs

These are the same drug, sarolaner, moxidectin and pyrantel, in the same monthly liver chew. The only real difference is the weight band: A doses dogs from 88.1 to 132 lb, B doses dogs from 11.1 to 22 lb. Buy the one that matches your dog's weight and never split or combine tablets to hit a dose. Owners and reviewers rate the formula highly for fast flea kill and broad coverage, and most dogs eat the chew without a fight.

  • Choose the Simparica Trio 88.1-132 lb 6-month supply if you have a large dog in that weight range and want six months of protection in one box.
  • Choose the Simparica Trio 11.1-22 lb 6-pack if you have a small dog or a puppy at least 8 weeks old within that weight band.

Prices

  • Simparica Trio Chewable Tablets for Dogs: $40.05 at Amazon (last seen Nov 14)
  • Simparica Trio Chewable Tablet for Dogs: $40.05 at Amazon (last seen Nov 14)
  • Difference: both cost the same at the latest prices (Nov 14)
Zoetis
Zoetis Simparica Trio Chewable Tablets for Dogs 88.1-132 lb 6 Month Supply

Simparica Trio Chewable Tablets for Dogs

Zoetis Simparica Trio Chewable Tablets for Dogs 88.1-132 lb 6 Month Supply

4.6(628 ratings)
$40.05at AmazonChecked 13 h ago
See all prices and details
Visit Amazon

Store links may earn us a commission. As an Amazon Associate, Deal.ai earns from qualifying purchases.

Pros
  • Covers a large-dog weight band in a single monthly chew
  • Same six-way parasite protection as the small-dog version
  • Liver flavor that most dogs take willingly
  • Six-month box cuts down on reordering
Cons
  • Needs a prescription before it ships
  • Non-returnable once dispensed
  • Wrong for any dog under 88.1 lb
Zoetis
Zoetis Simparica Trio Chewable Tablet 11.1-22 lbs 6 pcs

Simparica Trio Chewable Tablet for Dogs

Zoetis Simparica Trio Chewable Tablet 11.1-22 lbs 6 pcs

5(4 ratings)
$40.05at AmazonChecked 13 h ago
See all prices and details
Visit Amazon

Store links may earn us a commission. As an Amazon Associate, Deal.ai earns from qualifying purchases.

Pros
  • Doses small dogs and puppies from 8 weeks
  • Kills fleas within 4 hours and reaches 100% in 8 hours in studies
  • First combo preventative FDA-approved against six tick types, including deer ticks
  • Liver and beef flavor; 9 of 10 dogs took it voluntarily in a study
Cons
  • Needs a prescription before it ships
  • Non-returnable once dispensed
  • Wrong for any dog over 22 lb

What separates them

Simparica Trio Chewable Tablets for DogsSimparica Trio Chewable Tablet for Dogs
Dog weight bandDogs 88.1 to 132 lbDogs 11.1 to 22 lb
Active ingredientsSarolaner, moxidectin, pyrantelSarolaner, moxidectin, pyrantel
Supply length6 monthly chews6 monthly chews
FlavorLiverLiver and beef
Age suitabilityLabeled for dogs from 8 weeks at the minimum weight for the doseMarketed for adult dogs and puppies
Parasite coverageHeartworm, fleas, ticks, roundworms, hookworms, flea tapewormsHeartworm, fleas, ticks, roundworms, hookworms, flea tapeworms
Dosing flexibilityOne chew for the whole bandOne chew for the whole band
PrescriptionRequires vet approvalRequires vet approval

Price history

  • Simparica Trio Chewable Tablets for Dogs: lowest $40.05 on Nov 15 at Amazon.
  • Simparica Trio Chewable Tablet for Dogs: lowest $40.05 on Nov 15 at Amazon.

Prices at every store

Simparica Trio Chewable Tablets for Dogs

  • Tractor Supply CoNew

    In stock

    $236.48Free shippingChecked 8 h ago
    Visit Tractor Supply Co
  • BaxterBooNew

    In stock

    $236.48Checked 8 h ago
    Visit BaxterBoo
  • Valley Vet SupplyNew

    In stock

    $236.48Checked 8 h ago
    Visit Valley Vet Supply
  • AmazonNew

    Availability unknown

    As an Amazon Associate, Deal.ai earns from qualifying purchases.

    $40.05Checked 13 h ago
    Visit Amazon

Store links may earn us a commission. Some prices via Klarna.

All 5 stores and price history →

Simparica Trio Chewable Tablet for Dogs

  • Tractor Supply CoNew

    In stock

    $210.09Free shippingChecked 8 h ago
    Visit Tractor Supply Co
  • ChewyNew

    In stock

    $210.09Free shippingChecked 8 h ago
    Visit Chewy
  • BaxterBooNew

    In stock

    $210.09Checked 8 h ago
    Visit BaxterBoo
  • AmazonNew

    Availability unknown

    As an Amazon Associate, Deal.ai earns from qualifying purchases.

    $40.05Checked 13 h ago
    Visit Amazon

Store links may earn us a commission. Some prices via Klarna.

All 6 stores and price history →

Specs compared

SpecSimparica Trio Chewable Tablets for DogsSimparica Trio Chewable Tablet for Dogs
Food TypeDog ChewDog Chew
IngredientsLiverLiver, Beef
Special DietsFur & Skin CareFur & Skin Care
No. of Packs (pack)—6
Age Group—Adult, Puppy

What reviewers say

Simparica Trio Chewable Tablets for Dogs

  • 4.6 / 5628 ratings

Owners generally report that Simparica Trio is easy to give and that their dogs stay free of fleas and ticks. The most common complaints are digestive upset after dosing and the need for a vet prescription.

What people mention
  • Ease of dosingPraisedOwners say most dogs take the liver-flavored chew like a treat, without hiding it in food.
  • Flea and tick controlPraisedUsers report fewer fleas and attached ticks on dogs that spend time outdoors.
  • Digestive upsetCriticisedSome owners report vomiting or loose stool in the day or two after a dose.
  • PrescriptionMixedOwners note it needs a vet prescription and a heartworm test, which some find inconvenient.

Simparica Trio Chewable Tablet for Dogs

Owners and veterinarians generally rate Simparica Trio as a reliable, easy monthly all-in-one. The most common complaints are stomach upset in sensitive dogs and occasional refusal of the chew.

What people mention
  • ConveniencePraisedOwners like replacing separate flea, tick and heartworm products with a single monthly chew.
  • Stomach upsetCriticisedSome owners report vomiting or loose stools, especially in dogs with sensitive digestion.
  • PalatabilityMixedMost dogs take the liver and beef chew readily, but some refuse it or spit it out.
  • Flea controlPraisedUsers report fleas dying quickly and staying away with monthly dosing.

Questions and answers

Are these two products the same medication?
Yes. Both are Simparica Trio with the same three active ingredients. They differ only in the weight band each tablet is dosed for.
Can I give the large-dog chew to a small dog?
No. Giving a chew sized for 88.1 to 132 lb to an 11 to 22 lb dog overdoses it. Use the chew that matches your dog's weight.
Which is better for a puppy?
The 11.1-22 lb version fits puppies from 8 weeks old that weigh at least 11.1 lb. The large-dog chew is only for dogs in its own weight band.
Does Simparica Trio protect against heartworm?
Yes. Both sizes protect against heartworm disease along with fleas, ticks, roundworms, hookworms and flea tapeworms.
Do dogs actually eat it?
In a study, 9 out of 10 dogs took the chew voluntarily. It can be given with or without food.
Why does it need a prescription?
It is a prescription parasite preventative, so a vet has to approve the order. The product is also non-returnable once dispensed.

Ask our shopping agent

It checks today's price at every store, compares the alternatives and answers in about a minute.

Enter to send, Shift+Enter for a new line

More comparisons

  • Simparica Trio Dog Chewable Tablets 2.8-5.5 lb 6 Treatments vs Zoetis Simparica Trio Chewable Tablets for Dogs 88.1-132 lb 6 Month Supply
  • Simparica Trio Dog Chewable Tablets 2.8-5.5 lb 6 Treatments vs Zoetis Simparica Trio Chewable Tablet 11.1-22 lbs 6 pcs
  • Zoetis Simparica Trio Chewable Tablet 11.1-22 lbs 6 pcs vs Simparica Trio For Dogs 88.1-132 lbs (40-60 kg)

Buying guides that pick them

  • Best flea, tick and heartworm prevention for dogs