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Simparica Trio Chewable Tablets vs Simparica Trio XL Chew for Dogs

Both are the same drug, Simparica Trio, so the real difference is the weight band and pack size, not the formula. Product A is the 2.8–5.5 lb chew in a 6-month supply, built for small adult dogs. Product B is the 88.1–132 lb chew, a 3-pack for very large dogs. Owners and reviewers report the same things on both: fast flea kill, easy liver-flavored chews, and solid tick and heartworm coverage. Pick by your dog's weight, not by rating.

  • Choose the Simparica Trio 2.8–5.5 lb 6-pack if you have a small dog in that weight band and want a six-month supply in one box.
  • Choose the Simparica Trio 88.1–132 lb if your dog is a large or giant breed in that range and you want a three-month supply.

Prices

  • Simparica Trio Chewable Tablets: $203.51 at Chewy (checked today)
  • Simparica Trio XL Chew for Dogs: $66.95 at 79Pets.com (last seen Nov 14)
  • Difference: the Simparica Trio XL Chew for Dogs is $136.56 cheaper than the Simparica Trio Chewable Tablets at the latest prices (Nov 14 and Nov 15)
Simparica Trio
Simparica Trio Dog Chewable Tablets 2.8-5.5 lb 6 Treatments

Simparica Trio Chewable Tablets

Simparica Trio Dog Chewable Tablets 2.8-5.5 lb 6 Treatments

4.6(628 ratings)
$203.51at ChewyChecked 11 h ago
See all prices and details
Visit Chewy

Store links may earn us a commission. Price via Klarna.

Pros
  • Six-month supply in one box
  • Covers flea tapeworm as well as the other parasites
  • Large review base backs the rating
  • Small chew size suits toy and small breeds
Cons
  • Wrong dose for any dog over 5.5 lb
  • Small dogs can be fussy about chew size
Zoetis
Simparica Trio For Dogs 88.1-132 lbs (40-60 kg)

Simparica Trio XL Chew for Dogs

Simparica Trio For Dogs 88.1-132 lbs (40-60 kg)

4.9(13 ratings)
$66.95at 79Pets.comChecked 14 h ago
See all prices and details
Visit 79Pets.com
Pros
  • Dosed for large and giant breeds up to 132 lb
  • Same fast flea and tick kill as the small size
  • High owner rating, though from few reviews
  • Chew is sized for big mouths
Cons
  • Only a 3-month supply
  • Listing does not mention flea tapeworm coverage
  • Few ratings, so the score is less settled

What separates them

Simparica Trio Chewable TabletsSimparica Trio XL Chew for Dogs
Dog weight band2.8–5.5 lb (small dogs)88.1–132 lb (large and giant dogs)
Supply length6 monthly chews3 monthly chews
Active ingredientsSarolaner, moxidectin, pyrantelSarolaner, moxidectin, pyrantel
Parasite coverageFleas, ticks, heartworm, roundworm, hookworm, flea tapewormFleas, ticks, heartworm, roundworm, hookworm
Flea kill speedStarts within 4 hours, 100% in 8 hours in studiesWithin 4 to 8 hours
Minimum age8 weeks8 weeks
AdministrationLiver-flavored chew, with or without foodLiver-flavored chew, with or without food
Review volume4.6 from 628 ratings4.9 from 13 ratings

Price history

  • Simparica Trio Chewable Tablets: lowest $203.51 on Nov 15 at Tractor Supply Co.

Prices at every store

Simparica Trio Chewable Tablets

  • Tractor Supply CoNew

    In stock

    $203.51Free shippingChecked 11 h ago
    Visit Tractor Supply Co
  • ChewyNew

    In stock

    $203.51Free shippingChecked 11 h ago
    Visit Chewy
  • Valley Vet SupplyNew

    In stock

    $203.51Checked 11 h ago
    Visit Valley Vet Supply
  • AmazonNew

    Availability unknown

    As an Amazon Associate, Deal.ai earns from qualifying purchases.

    $203.51Checked 14 h ago
    Visit Amazon

Store links may earn us a commission. Some prices via Klarna.

All 6 stores and price history →

Simparica Trio XL Chew for Dogs

  • 79Pets.comNew

    In stockReturn policy

    $66.95Checked 14 h ago
    Visit 79Pets.com
Prices and history →

Specs compared

SpecSimparica Trio Chewable TabletsSimparica Trio XL Chew for Dogs
Food TypeSupplements—
Dog SizeMedium (11-25kg)—
Weight/pack. (oz)2.8—
ColorYellow, Gold—
No. of Packs (pack)6—
Age GroupAdult—
Special DietsDigestion and Stomach—
SupplementsJoint & Bone—
AnimalDog—
Minimum age—8 weeks of age
Administration frequency—one chew per month
Flea kill speed—within 4 to 8 hours after treatment
Show all 20 specsShow fewer specs
SpecSimparica Trio Chewable TabletsSimparica Trio XL Chew for Dogs
Flea re-infestation efficacy—35 days
Paralysis tick kill rate—98.9% of pre-existing paralysis ticks killed wi…
Form—Tasty liver flavoured chew
Sarolaner dosage—0.54 mg/lb (1.2 mg/kg)
Moxidectin dosage—0.011 mg/lb (24 μg/kg)
Pyrantel dosage—2.27 mg/lb (5 mg/kg)
Administration with food—with or without food
Weight range (XL)—40.1 – 60 kg

What reviewers say

Simparica Trio Chewable Tablets

  • 4.6 / 5628 ratings

Rated 4.6 out of 5 across 628 ratings, owners largely report it is easy to give and effective at keeping fleas and ticks off. Complaints center on stomach upset in some dogs and the need for a vet visit and prescription.

What people mention
  • Ease of dosingPraisedOwners say most dogs eat the liver-flavored chew without a fight.
  • Flea and tick controlPraisedReviewers report fleas and ticks gone after starting the monthly chew.
  • Stomach upsetCriticisedSome owners report vomiting or loose stool, usually after the first dose.
  • Prescription requirementMixedBuyers note the vet visit and heartworm test add steps before the first dose.

Simparica Trio XL Chew for Dogs

  • 4.9 / 513 ratings

Owners rate it 4.9 out of 5 and describe it as effective flea and tick protection that is easy to give as a chew.

What people mention
  • EffectivenessPraisedOwners say it works well against fleas and ticks.
  • Ease of givingPraisedThe liver-flavored chew is easy to give and dogs take it readily.
  • ValuePraisedBuyers feel the combined coverage is good value.

Questions and answers

Are these the same product in different sizes?
Yes. Both are Simparica Trio with sarolaner, moxidectin and pyrantel. The dose scales with body weight, so the only real choice is the band that matches your dog.
Which one lasts longer?
Product A covers six months and Product B covers three. Each chew protects for one month, so the box size sets how long you are covered.
Can I split a large chew for a small dog?
No. Do not split or share chews. Give the chew labeled for your dog's weight band, and ask your vet if your dog sits near a band boundary.
Is one better for puppies?
Both are approved from 8 weeks old, as long as the puppy meets the labeled minimum weight. Use the band that fits the puppy's current weight.
Do these cover tapeworms?
Product A's listing names flea tapeworms. Product B's listing names roundworms and hookworms but not tapeworm, so check with your vet if tapeworm coverage matters.
Is the higher rating on B meaningful?
It comes from 13 ratings against 628 for A. Treat it as a small sample. The drug and its performance are the same.

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More comparisons

  • Simparica Trio Dog Chewable Tablets 2.8-5.5 lb 6 Treatments vs Zoetis Simparica Trio Chewable Tablet 11.1-22 lbs 6 pcs
  • Simparica Trio Dog Chewable Tablets 2.8-5.5 lb 6 Treatments vs Zoetis Simparica Trio Chewable Tablets for Dogs 88.1-132 lb 6 Month Supply
  • Zoetis Simparica Trio Chewable Tablet 11.1-22 lbs 6 pcs vs Simparica Trio For Dogs 88.1-132 lbs (40-60 kg)

Buying guides that pick them

  • Best flea, tick and heartworm prevention for dogs