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Simparica Trio Chewable Tablets vs Simparica Trio Chewable Tablets for Dogs

These are the same drug, Simparica Trio, in different weight-band boxes, so the choice comes down to your dog's weight, not the formula. Both are once-monthly liver-flavored chews that kill fleas, ticks, heartworm larvae, roundworms, hookworms and flea tapeworms. Owners and vets rate the chew highly for palatability and fast flea kill, and the 4.6 rating holds across both listings. Buy the box that matches your dog's current weight, and recheck the band as a puppy grows.

  • Choose the Simparica Trio 2.8-5.5 lb box if your dog weighs between 2.8 and 5.5 pounds, such as a small adult breed or a young puppy past eight weeks.
  • Choose the Simparica Trio 88.1-132 lb box if your dog weighs between 88.1 and 132 pounds, such as a large or giant breed.

Prices

  • Simparica Trio Chewable Tablets: $203.51 at Chewy (checked today)
  • Simparica Trio Chewable Tablets for Dogs: $40.05 at Amazon (last seen Nov 14)
  • Difference: the Simparica Trio Chewable Tablets for Dogs is $163.46 cheaper than the Simparica Trio Chewable Tablets at the latest prices (Nov 14 and Nov 15)
Simparica Trio
Simparica Trio Dog Chewable Tablets 2.8-5.5 lb 6 Treatments

Simparica Trio Chewable Tablets

Simparica Trio Dog Chewable Tablets 2.8-5.5 lb 6 Treatments

4.6(628 ratings)
$203.51at ChewyChecked 8 h ago
See all prices and details
Visit Chewy

Store links may earn us a commission. Price via Klarna.

Pros
  • Same broad parasite coverage as the large-dog box
  • Small chew size suits toy breeds and puppies
  • Once-monthly dosing is easy to keep on schedule
  • Most dogs take it voluntarily; can be given with or without food
Cons
  • Only for dogs in the 2.8-5.5 lb band
  • Requires a vet prescription
  • Not for puppies under eight weeks
Zoetis
Zoetis Simparica Trio Chewable Tablets for Dogs 88.1-132 lb 6 Month Supply

Simparica Trio Chewable Tablets for Dogs

Zoetis Simparica Trio Chewable Tablets for Dogs 88.1-132 lb 6 Month Supply

4.6(628 ratings)
$40.05at AmazonChecked 12 h ago
See all prices and details
Visit Amazon

Store links may earn us a commission. As an Amazon Associate, Deal.ai earns from qualifying purchases.

Pros
  • Covers fleas, ticks, heartworm and intestinal worms in one chew
  • One monthly dose for large and giant breeds
  • Liver flavor that most dogs accept
  • Kills fleas fast, before they lay eggs
Cons
  • Only for dogs in the 88.1-132 lb band
  • Requires a vet prescription
  • Dogs outside the band need a different box

What separates them

Simparica Trio Chewable TabletsSimparica Trio Chewable Tablets for Dogs
Dog weight band2.8-5.5 lb88.1-132 lb
Active ingredientsSarolaner, moxidectin, pyrantelSarolaner, moxidectin, pyrantel
Parasites coveredFleas, six tick types, heartworm, roundworm, hookworm, flea tapewormFleas, six tick types, heartworm, roundworm, hookworm, flea tapeworm
Dosing scheduleOne chew monthlyOne chew monthly
Minimum ageEight weeksEight weeks
FlavorLiver-flavored chewLiver-flavored chew
Supply lengthSix treatmentsSix treatments
Best forToy and small breedsLarge and giant breeds

Price history

  • Simparica Trio Chewable Tablets: lowest $203.51 on Nov 15 at Tractor Supply Co.
  • Simparica Trio Chewable Tablets for Dogs: lowest $40.05 on Nov 15 at Amazon.

Prices at every store

Simparica Trio Chewable Tablets

  • Tractor Supply CoNew

    In stock

    $203.51Free shippingChecked 8 h ago
    Visit Tractor Supply Co
  • ChewyNew

    In stock

    $203.51Free shippingChecked 8 h ago
    Visit Chewy
  • Valley Vet SupplyNew

    In stock

    $203.51Checked 8 h ago
    Visit Valley Vet Supply
  • AmazonNew

    Availability unknown

    As an Amazon Associate, Deal.ai earns from qualifying purchases.

    $203.51Checked 11 h ago
    Visit Amazon

Store links may earn us a commission. Some prices via Klarna.

All 6 stores and price history →

Simparica Trio Chewable Tablets for Dogs

  • Tractor Supply CoNew

    In stock

    $236.48Free shippingChecked 8 h ago
    Visit Tractor Supply Co
  • BaxterBooNew

    In stock

    $236.48Checked 8 h ago
    Visit BaxterBoo
  • Valley Vet SupplyNew

    In stock

    $236.48Checked 8 h ago
    Visit Valley Vet Supply
  • AmazonNew

    Availability unknown

    As an Amazon Associate, Deal.ai earns from qualifying purchases.

    $40.05Checked 12 h ago
    Visit Amazon

Store links may earn us a commission. Some prices via Klarna.

All 5 stores and price history →

Specs compared

SpecSimparica Trio Chewable TabletsSimparica Trio Chewable Tablets for Dogs
Food TypeSupplementsDog Chew
Special DietsDigestion and StomachFur & Skin Care
Dog SizeMedium (11-25kg)—
Weight/pack. (oz)2.8—
ColorYellow, Gold—
No. of Packs (pack)6—
Age GroupAdult—
SupplementsJoint & Bone—
AnimalDog—
Ingredients—Liver

What reviewers say

Simparica Trio Chewable Tablets

  • 4.6 / 5628 ratings

Rated 4.6 out of 5 across 628 ratings, owners largely report it is easy to give and effective at keeping fleas and ticks off. Complaints center on stomach upset in some dogs and the need for a vet visit and prescription.

What people mention
  • Ease of dosingPraisedOwners say most dogs eat the liver-flavored chew without a fight.
  • Flea and tick controlPraisedReviewers report fleas and ticks gone after starting the monthly chew.
  • Stomach upsetCriticisedSome owners report vomiting or loose stool, usually after the first dose.
  • Prescription requirementMixedBuyers note the vet visit and heartworm test add steps before the first dose.

Simparica Trio Chewable Tablets for Dogs

  • 4.6 / 5628 ratings

Owners generally report that Simparica Trio is easy to give and that their dogs stay free of fleas and ticks. The most common complaints are digestive upset after dosing and the need for a vet prescription.

What people mention
  • Ease of dosingPraisedOwners say most dogs take the liver-flavored chew like a treat, without hiding it in food.
  • Flea and tick controlPraisedUsers report fewer fleas and attached ticks on dogs that spend time outdoors.
  • Digestive upsetCriticisedSome owners report vomiting or loose stool in the day or two after a dose.
  • PrescriptionMixed

Questions and answers

Are these two products the same medication?
Yes. Both are Simparica Trio with sarolaner, moxidectin and pyrantel. The only difference is the weight band the chew is dosed for.
Which one should I buy for a growing puppy?
Buy for your puppy's current weight and recheck the band at each refill. Puppies can cross into a higher band within a few months, and the dose must match the weight on the label.
Does Simparica Trio protect against heartworm?
Yes. The monthly chew prevents heartworm disease along with fleas, ticks, roundworms, hookworms and flea tapeworms. It is not a treatment for an existing heartworm infection.
Can I split a large-dog chew for a small dog?
No. Do not split or share chews between weight bands. Give the chew labeled for your dog's weight so the dose is correct.
Is Simparica Trio safe for dogs with food allergies?
The chew is liver-flavored and most dogs take it, but check the full ingredient list with your vet if your dog has a known allergy. It can be given with or without food.
How long does one box last?
Each box holds six chews, one per month, so a box covers six months of protection for one dog.

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More comparisons

  • Simparica Trio Dog Chewable Tablets 2.8-5.5 lb 6 Treatments vs Zoetis Simparica Trio Chewable Tablet 11.1-22 lbs 6 pcs
  • Zoetis Simparica Trio Chewable Tablets for Dogs 88.1-132 lb 6 Month Supply vs Zoetis Simparica Trio Chewable Tablet 11.1-22 lbs 6 pcs
  • Simparica Trio Dog Chewable Tablets 2.8-5.5 lb 6 Treatments vs Simparica Trio For Dogs 88.1-132 lbs (40-60 kg)

Buying guides that pick them

  • Best flea, tick and heartworm prevention for dogs
Owners note it needs a vet prescription and a heartworm test, which some find inconvenient.