Is Advantix safe for cats?

No. Permethrin is highly toxic to cats, so never apply Advantix to a cat or let a cat lick a treated dog. Keep treated dogs away from cats until the product dries.

How often do I apply it?

Apply one tube every 30 days. The 4-month pack gives four monthly doses.

Does it work after swimming or a bath?

Yes, once the solution has dried for 24 hours it is waterproof and stays effective through bathing and swimming.

What weight of dog is this for?

This size is for dogs weighing 21–55 lbs. Use a different size for smaller or larger dogs.

Is it cheaper than a vet-prescribed flea treatment?

At $79.92 for four doses at Amazon as of November 4, 2026, it costs about $20 per month and needs no prescription, which is often less than prescription oral products.

Where can I buy the Advantix Dog 4 Month Topical Flea Treatment?

8 stores we checked sell it, including Amazon, Chewy.com, Petco.com, PetSmart, Target.

Advantix Dog 4 Month Topical Flea Treatment

Q: Where is the Advantix Dog 4 Month Topical Flea Treatment cheapest?

At Amazon, for $79.92, as of our latest check.

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$79.92at AmazonObserved at 5:09 AM

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Our take on the Advantix Dog 4 Month Topical Flea Treatment

Advantix is a monthly spot-on flea and tick treatment for dogs weighing 21–55 lbs. It combines imidacloprid, permethrin and pyriproxyfen to kill adult fleas and stop eggs and larvae from developing, and it also repels and kills ticks and mosquitoes. The tube is waterproof after 24 hours and fragrance-free. The best new price is $79.92 at Amazon as of November 4, 2026, for a 4-month supply, or about $20 per dose.

Best forDogs 21–55 lbs with fleas or ticks