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Simparica TRIO Chewable Tablets for Dogs

Simparica TRIO Chewable Tablets for Dogs

Best price now

$234.77at AmazonObserved at 5:09 AM

Compared across 2 stores. Prices are checked against each store and labelled with when.

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Our take on the Simparica TRIO Chewable Tablets for Dogs

Simparica Trio is a monthly oral chew that combines three drugs in one tablet: sarolaner for fleas and ticks, moxidectin for heartworm and roundworms/hookworms, and pyrantel for roundworms and hookworms. It kills fleas within 4 to 8 hours and keeps killing for 35 days, and it kills paralysis ticks within 24 hours. It is for dogs 8 weeks and older, dosed by weight, and comes in a liver-flavored chew. The best new price is $234.77 at Amazon as of November 4, 2026, with two stores listing it new.

Best forOwners who want flea, tick, heartworm and worm cover in one monthly chewDogs that take tablets easily and refuse topical treatmentsMulti-dog households wanting one simple monthly routinePuppies from 8 weeks old, dosed by weight
Pros
  • Three parasite classes covered in a single monthly dose
  • Fast flea kill, within 4 to 8 hours
  • 35 days of flea efficacy, so a monthly dose leaves margin
  • Kills paralysis ticks within 24 hours
  • Liver-flavored chew is easy to give for most dogs
Cons
  • Prescription required in most markets
  • Must be given with food or shortly after for reliable absorption
  • Not for dogs under 8 weeks or under the labeled weight minimum
  • Does not cover tapeworm, so tapeworm risk needs a separate plan
  • Chewable only; no topical or injectable version

Simparica TRIO Chewable Tablets for Dogs prices at every store

  • Petco.comNew

    In stock

    $44.63Free shippingObserved at 5:09 AM
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  • AmazonNew

    Availability unknown

    As an Amazon Associate, Deal.ai earns from qualifying purchases.

    $234.77Observed at 5:09 AM
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Simparica TRIO Chewable Tablets for Dogs price history

Lowest price we've seen: $44.63 on Nov 4 at Petco.com. Tracked across 2 stores since Nov 4.

What reviewers say

Owners and vets generally rate Simparica Trio highly for convenience and fast flea control, and many report their dogs take the chew without fuss. The main complaints are cost and occasional stomach upset or refusal of the chew in picky dogs.

Pros
  • One chew replaces several separate products
  • Fast flea and tick knockdown
  • Most dogs accept the liver flavor
  • Simple monthly schedule
Cons
  • Higher cost than buying single-purpose products
  • Some dogs vomit or have loose stool after dosing
  • Picky dogs may spit out the chew
  • No tapeworm coverage

Specifications

Animal
Dog
Minimum age
8 weeks of age and olderSource
Dosing frequency
once a monthSource
Sarolaner dosage
0.54 mg/lb (1.2 mg/kg)Source
Moxidectin dosage
0.011 mg/lb (24 μg/kg)Source
Pyrantel dosage
2.27 mg/lb (5 mg/kg)Source
Administration route
FOR ORAL USE IN DOGS ONLYSource
Form
flavored, chewable tabletSource
Flea kill speed
within 4 to 8 hours after treatmentSource
Flea efficacy duration
35 daysSource
Paralysis tick kill
within 24 hours of treatmentSource
Flavor
liver flavoured chewSource

Questions and answers

Is Simparica Trio worth it compared with separate products?
It replaces a flea/tick product, a heartworm preventive and a dewormer with one monthly chew. That convenience is the main reason owners pay more. If your dog already tolerates separate products well and cost matters, compare the totals.
How does it compare with NexGard or Bravecto?
Simparica Trio adds heartworm and roundworm/hookworm coverage in the same chew, which NexGard and Bravecto do not. Bravecto lasts longer per dose but does not cover heartworm. Choose based on which parasites matter in your area.
Does my dog need to take it with food?
Yes. Giving the chew with a meal or shortly after improves absorption of the moxidectin. The label dosing is by body weight, so weigh your dog before choosing a tablet size.
Can puppies take it?
It is labeled for dogs 8 weeks and older, dosed by weight. Younger puppies or dogs below the smallest weight band need a different product and a vet's advice.
Does it cover tapeworms?
No. Simparica Trio covers roundworms and hookworms but not tapeworms. Dogs with flea exposure or hunting habits may need a separate tapeworm treatment.
When is the best time to buy it?
It is a prescription product, so prices move with the pharmacy rather than seasonal sales. The best new price was $234.77 at Amazon as of November 4, 2026, across two stores; check the price history before ordering a multi-pack.
Where is the Simparica TRIO Chewable Tablets for Dogs cheapest?
At Amazon, for $234.77, as of our latest check.
Where can I buy the Simparica TRIO Chewable Tablets for Dogs?
2 stores we checked sell it, including Petco.com, Amazon.

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Compare the Simparica TRIO Chewable Tablets for Dogs

  • Simparica TRIO Chewable Tablets for Dogs vs NexGard PLUS
  • Bravecto for Dogs - 12-week dose (Rx) vs Simparica TRIO Chewable Tablets for Dogs
  • Simparica TRIO Chewable Tablets for Dogs vs Bravecto Chews for Dogs

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