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NexGard PLUS

NexGard PLUS

Best price now

$115.19at Chewy.comObserved at 5:09 AM

Compared across 2 stores. Prices are checked against each store and labelled with when.

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Our take on the NexGard PLUS

NexGard PLUS is a monthly beef-flavored chew that protects dogs against fleas, ticks, roundworms and heartworm disease. It combines afoxolaner, moxidectin and pyrantel in one tablet, so it replaces a separate heartworm preventive and dewormer. The 33.1–66 lb box of 6 chews is $115.19 at Chewy.com as of November 4, 2026, the lowest of the two stores listing it new. That works out to about $19 per month of protection.

Best forDogs 33.1–66 lbs on a monthly all-in-one preventiveOwners who want to skip a separate heartworm pillPuppies from 8 weeks oldDogs that take chewables more easily than topicals
Pros
  • Covers fleas, ticks, roundworms and heartworm in one chew
  • Beef-flavored and given orally, no topical residue
  • Monthly dosing, 6 chews per box
  • Puppies can start at 8 weeks
  • Listed as suitable for MDR1 gene deficient dogs
Cons
  • One-month supply per box, so repeat purchases add up
  • Only for dogs in the 33.1–66 lb weight band; other sizes need a different box
  • Requires a prescription in most US states
  • Does not cover tapeworms or whipworms
  • Some dogs vomit or refuse the chew

NexGard PLUS prices at every store

  • Chewy.comNew

    In stock

    $115.19Free shippingObserved at 5:09 AM
    Visit store
  • PetMart PharmacyNew

    In stock

    $115.20Free shippingObserved at 5:09 AM
    Visit store

Also available at

  • AmazonCheck price at Amazon

NexGard PLUS price history

Lowest price we've seen: $115.19 on Nov 4 at Chewy.com. Tracked across 3 stores since Nov 4.

What reviewers say

Owners of NexGard PLUS generally report it is easy to give and effective against fleas and ticks, and they like dropping a separate heartworm pill. Complaints center on cost and the occasional dog that vomits or spits it out.

Pros
  • Easy to give as a beef chew
  • Flea and tick control holds up between doses
  • One chew replaces two products
  • Works for puppies and MDR1 dogs
Cons
  • Higher price than older NexGard alone
  • Some dogs vomit after dosing
  • Not every dog likes the taste
  • Prescription requirement adds a vet visit

Specifications

Targeted Pests
Fleas, Roundworms, Ticks
Active Ingredient
Moxidectin, Afoxolaner, Pyrantel
Administration Method
Chewable tablet, Oral
Life Stage Age
Puppies as young as 8 weeks of age
Treatment Frequency
Monthly
Dosage Concentration
75 mg Afoxolaner
Dosage Duration
Monthly
Formulation Type
Chewable
Formulation
Water-Resistant, Waterproof
Lifecycle Targeted
Adults (fleas)
Animal Type
Dogs, Puppies
Suitable For Health Status
MDR1 gene deficient dogs
Treatment Type
Prevention, Treatment
Supply Duration
1 month supply
Supply Amount
6 tablets
Weight Range
33.1-66 lbs
Contains
Afoxolaner, Moxidectin, Pyrantel
Package Type
Box (Purple)
Scent
Beef-flavored

Questions and answers

Is NexGard PLUS worth it over plain NexGard?
Yes if you also want heartworm and roundworm coverage. Plain NexGard handles fleas and ticks only, so PLUS saves you a second monthly product. If your dog is already on a separate heartworm preventive, plain NexGard may cost less.
What weight of dog is this box for?
This purple box is for dogs 33.1–66 lbs. NexGard PLUS comes in other box colors for smaller and larger dogs, so match the weight band to your dog's current weight.
Can puppies take NexGard PLUS?
Yes, puppies can start at 8 weeks of age. Use the correct weight band, and check with your vet for puppies under the minimum weight for the smallest box.
Does it cover tapeworms?
No. NexGard PLUS covers roundworms, not tapeworms or whipworms. If tapeworms are a concern, ask your vet about a separate dewormer.
How often do I give it?
One chew once a month, ideally on the same date each month. Each box holds 6 chews, a six-month supply.
When is the price lowest?
The best new price was $115.19 at Chewy.com as of November 4, 2026. Multi-box bundles and autoship discounts are the usual ways to lower the per-chew cost.
Where is the NexGard PLUS cheapest?
At Chewy.com, for $115.19, as of our latest check.
Where can I buy the NexGard PLUS?
3 stores we checked sell it, including Chewy.com, PetMart Pharmacy, Amazon.

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