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K9 Advantix
K9 Advantix II Flea and Tick Prevention for Dogs

K9 Advantix II Flea and Tick Prevention for Dogs

4.5· 136 ratings

Best price now

$19.97at WalmartObserved at 5:11 AM

45% under what the other stores charge

Compared across 4 stores. Prices are checked against each store and labelled with when.

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Our take on the K9 Advantix II Flea and Tick Prevention for Dogs

K9 Advantix II is a monthly spot-on treatment for dogs that kills and repels fleas, ticks and mosquitoes, and also controls biting flies and chewing lice. It combines imidacloprid, permethrin and pyriproxyfen, kills fleas within 12 hours, and becomes waterproof 24 hours after application. The 4-tube pack for dogs 21-55 lbs is $19.97 at Walmart as of November 4, 2026, the lowest of the four stores listing it new.

Best forDog owners who want flea, tick and mosquito control in one productDogs 21-55 lbs, 7 weeks or olderOwners who prefer a topical over an oral pillHouseholds that need a waterproof, fragrance-free option
Pros
  • Kills fleas within 12 hours and newly arriving fleas within 2 hours
  • Repels ticks and mosquitoes rather than only killing them
  • Pyriproxyfen stops flea eggs and larvae from developing
  • Waterproof after 24 hours; fragrance-free; no prescription needed
  • Four monthly doses per pack
Cons
  • Not for cats and toxic to them; keep treated dogs separated from cats
  • Permethrin-based, so not for dogs with a permethrin sensitivity
  • Needs 24 hours to become waterproof, so no swimming or bathing right away
  • Monthly reapplication required; one pack lasts about four months per dog

K9 Advantix II Flea and Tick Prevention for Dogs prices at every store

  • WalmartNew

    In stock

    $19.97+ $6.99 shippingObserved at 5:11 AM
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  • PetsenseNew

    In stockReturn policy

    $35.99Observed at 5:09 AM
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  • PetSmartNew

    In stock

    $35.68+ $6.99 shippingObserved at 5:09 AM
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  • Chewy.comNew

    In stock

    $135.96Free shippingObserved at 5:09 AM
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Also available at

  • JeffersCheck price at Jeffers
  • AmazonCheck price at Amazon
  • Petco.comCheck price at Petco.com
  • TargetCheck price at Target
  • Tractor Supply CompanyCheck price at Tractor Supply Company
  • Lambert Vet SuppliesCheck price at Lambert Vet Supplies
  • Pet Supplies 4 LessCheck price at Pet Supplies 4 Less

K9 Advantix II Flea and Tick Prevention for Dogs price history

Lowest price we've seen: $19.97 on Nov 4 at Walmart. Tracked across 7 stores since Nov 4.

What reviewers say

Owners rate it 4.5 out of 5 across 136 ratings, with most reporting fewer fleas and ticks and easy application. Complaints center on the smell of the liquid going on and on skin reactions in a minority of dogs.

Pros
  • Clears fleas quickly
  • Easy to apply between the shoulder blades
  • Holds up through swimming and rain after the first day
Cons
  • Strong smell at application
  • Occasional itching or redness at the application site
  • Some owners report fleas returning before the month is up

From Petsense

  • Protects dogs 21-55 lbs. from fleas, ticks, mosquitoes, biting flies and lice
  • Kills fleas within 12 hours of application
  • Vet-recommended formula kills and repels on contact so fleas don't have to bite your dog to die
  • Easy-to-apply topical treatment is fragrance-free
  • Waterproof after 24 hours
  • No prescription needed
Sizing
For dogs at least 7 weeks old weighing 21-55 lbs.
Packs
2 Month, 4 Month and 6 Month options

About the K9 Advantix II Flea and Tick Prevention for Dogs

K9 Advantix II for Dogs

K9 Advantix® II is a monthly topical treatment that kills and repels fleas, ticks, and mosquitoes while also controlling biting flies and chewing lice. Its three active ingredients—imidacloprid, permethrin, and pyriproxyfen—work together to kill existing fleas, help prevent flea reinfestation, and provide protection against multiple external parasites.

This easy-to-apply, fragrance-free formula kills fleas on dogs within 12 hours of initial application and kills newly arriving fleas within 2 hours. It remains effective for up to four weeks and becomes waterproof after 24 hours when used as directed.

Features:

Broad-spectrum pest control: Kills and repels fleas, ticks, and mosquitoes; also controls biting flies and chewing lice.

Fast flea control: Kills existing fleas within 12 hours and newly arriving fleas within 2 hours.

Flea life-cycle control: Pyriproxyfen helps prevent flea development for up to four weeks.

Monthly protection: Provides up to four weeks of protection per application.

Convenient topical formula: Easy-to-apply, fragrance-free treatment with no pills required.

Waterproof: Becomes waterproof after 24 hours when used as directed.

• No prescription required.

Active Ingredients:

• Imidacloprid 8.80%

• Permethrin 44.00%

• Pyriproxyfen 0.44%

Directions:

Apply the contents of one weight-appropriate tube topically as directed on the product label. Use only on dogs and puppies at least 7 weeks old and weighing 4 lb or more.

For best results, avoid bathing your dog for 48 hours before and after application. Swimming or frequent bathing may reduce the duration of protection. Follow the package instructions for application sites and retreatment intervals.

Cautions/Warnings:

For dogs only. Do not use on cats. Keep treated dogs away from cats until the application site is completely dry, and follow all label precautions to prevent cat exposure. Do not allow the product to contact the dog's eyes or mouth. Keep out of reach of children.

Monitor your dog after application. Possible adverse reactions include skin redness, scratching, discomfort, vomiting, or diarrhea. If signs persist or become severe, contact a veterinarian. Consult your veterinarian before use on debilitated, elderly, pregnant, or nursing dogs, or if your dog is taking medication. Individual sensitivities to pesticide products may occur.

Available Sizes:

Dog Weight

Size

Specifications

Active ingredients
Imidacloprid - 8.80% Permethrin - 44.00% Pyriproxyfen - 0.44%Source
Application frequency
Apply on your pet once a monthSource
Minimum dog age
7 weeks of age or olderSource
Minimum dog weight
4 lbsSource

Questions and answers

Is K9 Advantix II worth it over a cheaper flea-only product?
It covers fleas, ticks and mosquitoes plus biting flies and lice, which most cheaper flea-only drops do not. If ticks and mosquitoes are a real problem where you live, the extra coverage is the reason to pay more.
How does it compare with Frontline Plus?
Both are monthly topicals that kill fleas and ticks and stop flea eggs from developing. K9 Advantix II adds mosquito repellency and biting fly control; Frontline Plus does not.
Can I use it on my cat?
No. It contains permethrin, which is toxic to cats. Use a cat-labeled product and keep treated dogs away from cats until the application site is dry.
How soon can my dog swim or get a bath?
Wait 24 hours after application. The product becomes waterproof after that point and stays effective through bathing and swimming.
What weight range does this pack fit?
This pack is for dogs 21-55 lbs. K9 Advantix II comes in separate sizes for smaller and larger dogs, so match the tube to your dog's weight.
When is the price lowest?
The best new price was $19.97 at Walmart as of November 4, 2026. Multi-pack and seasonal flea-season promotions are the usual times to stock up.
Where is the K9 Advantix II Flea and Tick Prevention for Dogs cheapest?
At Walmart, for $19.97, 45% under what the other stores charge, as of our latest check.
What do buyers say about the K9 Advantix II Flea and Tick Prevention for Dogs?
Rated 4.5 out of 5 from 136 ratings.
Where can I buy the K9 Advantix II Flea and Tick Prevention for Dogs?
11 stores we checked sell it, including Walmart, Petsense, PetSmart, Chewy.com, Jeffers.

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Package contents
4 applicator tubesSource
Waterproof
WaterproofSource
Flea kill time
within 12 hoursSource
Protection duration
up to 4 weeksSource
Targeted Pests
Fleas, Mosquitoes, Ticks
Active Ingredient
Imidacloprid, Permethrin, Pyriproxyfen
Administration Method
Topical, Spot-on
Life Stage Age
Adult
Treatment Frequency
Monthly
Dosage Concentration
0.44% (pyriproxyfen)
Dosage Duration
30 days
Formulation Type
Topical Solution
Formulation
Waterproof (after 24 hours)
Lifecycle Targeted
Flea eggs, All life stages of fleas, Larvae, Pupae
Animal Type
Dogs
Suitable For Health Status
Sensitive skin
Treatment Type
Treatment, Prevention
Supply Duration
1 month supply
Supply Amount
1 dose
Weight Range
21-55 lbs