
Zoetis Simparica Trio Chewable Tablets for Dogs
Best price now
96% under what the other stores charge
Compared across 8 stores. Prices are checked against each store and labelled with when.

96% under what the other stores charge
Compared across 8 stores. Prices are checked against each store and labelled with when.
It checks today's price at every store, compares the alternatives and answers in about a minute.
Simparica Trio is a monthly prescription chew that combines three drugs — sarolaner, moxidectin and pyrantel — to prevent heartworm disease and control fleas, ticks, roundworms and hookworms in one dose. It starts killing fleas within four hours and is the first combination product FDA-approved to kill six tick species, including the deer tick linked to Lyme disease. It suits owners who want one chew instead of separate flea, tick, heartworm and dewormer products, and it is approved for puppies from eight weeks old at the labeled minimum weight. Vets prescribe it heavily, and most dogs take the liver-flavored chew willingly, though some owners report digestive upset or reluctance in picky dogs.
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Lowest price we've seen: $38.90 on Nov 15 at Tractor Supply Co. Tracked across 20 stores since Nov 15.
Owners and vets rate Simparica Trio highly for combining flea, tick, heartworm and worm protection in one monthly chew, and most say their dogs eat it without fuss. Complaints center on stomach upset in some dogs and the need for a prescription.
| Weight (lb.) | Sarolaner per Tablet (mg | Moxidectin per Tablet (m | Pyrantel per Tablet (mg) | Number of Tablets Admini |
|---|---|---|---|---|
| 2.8 to 5.5 lb. | 3.0 | 0.06 | 12.5 | 1 |
| 5.5 to 11 lb. | 6.0 | 0.12 | 25 | |
| 11-22 lb. | 12 | 0.24 | 50 | |
| 22-44 lb. | 24 | 0.48 | 100 | |
| 44-88 lb. | 48 | 0.96 | 200 | |
| 88-132 lb. | 72 | 1.44 | 300 |
Simparica Trio is a monthly liver-flavored chewable tablet for dogs. It protects against heartworm disease, fleas, ticks, flea tapeworms, roundworms and hookworms. The active ingredients are sarolaner, moxidectin and pyrantel (as pyrantel pamoate).
It starts killing fleas within 4 hours and kills fleas before they can lay eggs. It is FDA-approved to kill six types of tick, including the deer tick that may carry Lyme infections. It is approved for puppies as young as eight weeks old that weigh at least the minimum weight for the dose.
Give one tablet orally once a month, with or without food. The dose is chosen by the dog's weight. Make sure the dog eats the whole dose. If a dose is missed, give it right away and resume monthly dosing. It is for oral use in dogs only and requires a valid prescription.