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Simparica Trio is a monthly oral chew for puppies that combines three drugs: sarolaner for fleas and ticks, moxidectin for heartworm and hookworm, and pyrantel for roundworms and hookworms. It is one of the few single chews that covers heartworm, fleas, ticks and intestinal worms together, which saves owners from stacking separate products. It suits puppies from 8 weeks old weighing 2.8–5.5 lbs, and the liver-flavored chew is easier to give than a topical. Compared with flea-only chews or separate heartworm preventives, it covers more parasites per dose, though it is not a dewormer for tapeworm and does not repel ticks.
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Lowest price we've seen: $38.90 on Nov 15 at Lambert Vet Supply. Tracked across 6 stores since Nov 15.
Owners of young puppies generally report the chew is easy to give and that flea problems clear quickly. Some note picky puppies refuse the liver flavor, and a few mention mild stomach upset after the first dose.
Simparica Trio is a monthly liver-flavored chewable for puppies and small dogs weighing 2.8 to 5.5 lbs (1.25 to 2.5 kg). It can be given from 8 weeks of age.
It combines three active ingredients.









