Simparica Trio Chewable Tablet for Dogs vs Simparica TRIO Chewable

These are the same drug: sarolaner, moxidectin and pyrantel in a liver-flavored, five-sided chew given once a month. The brown box is simply the 88.1–132 lb (40.1–60 kg) size band of Simparica Trio, so the choice is about matching your dog's weight, not picking a better formula. Both start killing fleas within 4–8 hours, cover fleas for about 35 days, kill most paralysis ticks within 24 hours, and are safe from 8 weeks. Owners and reviewers rate it highly for convenience and palatability; the main complaints are the prescription requirement and that chews are non-returnable.

• Choose the Simparca Trio brown box if your dog weighs 88.1–132 lb and you want the correct XL dose band.
• Choose the Simparica Trio chew if your dog falls in a different weight band, from 1.25–2.5 kg puppies up to 40.1–60 kg.