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Simparica Trio Chewable Tablet for Dogs vs Simparica Trio Chewables for Medium Dogs

Both products are the same drug: sarolaner, moxidectin and pyrantel in a liver-flavored monthly chew. The only real difference is the weight band, so the choice comes down to your dog's weight, not to which product is better. The brown box covers dogs from 88.1 to 132 lbs; the blue pack covers 22.1 to 44 lbs. Owners and vets rate Simparica Trio highly for its broad coverage and fast flea kill, and the chew is well accepted. Dosing the wrong band risks under- or overdosing, so match the pack to the dog.

  • Choose the Simparica Trio brown box if your dog weighs between 88.1 and 132 lbs and you want one monthly chew that covers heartworm, fleas, ticks, roundworms and hookworms.
  • Choose the Simparica blue pack if your dog weighs between 22.1 and 44 lbs and you want the same monthly combination protection in the correct dose for a medium dog.

Prices

  • Simparica Trio Chewable Tablet for Dogs: $45.20 at Amazon (last seen Nov 14)
  • Simparica Trio Chewables for Medium Dogs: $43.48 at Allivet Pet Pharmacy (last seen Nov 14)
  • Difference: the Simparica Trio Chewables for Medium Dogs is $1.72 cheaper than the Simparica Trio Chewable Tablet for Dogs at the latest prices (Nov 14)
Simparica Trio
Simparica Trio Chewable Tablet for Dogs 88.1-132.0 lbs Brown Box

Simparica Trio Chewable Tablet for Dogs

Simparica Trio Chewable Tablet for Dogs 88.1-132.0 lbs Brown Box

$45.20at AmazonChecked 14 h ago
See all prices and details
Visit Amazon

Store links may earn us a commission. As an Amazon Associate, Deal.ai earns from qualifying purchases.

Pros
  • Correct dose for large and giant dogs up to 132 lbs
  • Same three active ingredients as the medium pack
  • One monthly chew covers heartworm, fleas, ticks and two worm types
  • Liver flavor and pentagon shape are easy to give
  • Minimum age of 8 weeks suits most puppies once they reach the weight band
Cons
  • Wrong dose for any dog under 88.1 lbs
  • Only covers one weight band, so multi-dog homes need several packs
  • Requires consistent monthly dosing to keep heartworm protection
Simparica
Simparica Trio Chewables For Medium Dogs 22.1–44lbs (10.1-20Kg) Blue

Simparica Trio Chewables for Medium Dogs

Simparica Trio Chewables For Medium Dogs 22.1–44lbs (10.1-20Kg) Blue

4.8(39 ratings)
$43.48at Allivet Pet PharmacyChecked 14 h ago
See all prices and details
Visit Allivet Pet Pharmacy
Pros
  • Correct dose for medium dogs from 22.1 to 44 lbs
  • Fast flea kill, starting within 4–8 hours
  • 35 days of flea efficacy from one chew
  • Kills 98.9% of pre-existing paralysis ticks within 24 hours
  • Rated 4.8 out of 5 by owners
Cons
  • Wrong dose for dogs outside 22.1–44 lbs
  • Only covers one weight band
  • Requires consistent monthly dosing to keep heartworm protection

What separates them

Simparica Trio Chewable Tablet for DogsSimparica Trio Chewables for Medium Dogs
Dog weight band88.1–132 lbs (large/giant dogs)22.1–44 lbs (medium dogs)
Active ingredientsSarolaner, moxidectin, pyrantelSarolaner, moxidectin, pyrantel
Sarolaner strength12 mg per chewNot stated for this pack
Pyrantel strength50 mg per chewNot stated for this pack
Dosing frequencyOnce a monthOne chew per month
Minimum age8 weeks8 weeks
Flea kill speedNot statedStarts within 4–8 hours; 35-day efficacy
Flavor and formLiver-flavored pentagon chew, 14 mmLiver-flavored pentagon chew

Price history

  • Simparica Trio Chewable Tablet for Dogs: lowest $40.05 on Nov 15 at Tractor Supply Company.
  • Simparica Trio Chewables for Medium Dogs: lowest $39.47 on Nov 15 at Amazon.

Prices at every store

Simparica Trio Chewable Tablet for Dogs

  • Tractor Supply CompanyNew

    In stock

    $40.05+ $6.95 shippingChecked 14 h ago
    Visit Tractor Supply Company
  • ChewyNew

    In stock

    $236.48Free shippingChecked 12 h ago
    Visit Chewy
  • AmazonNew

    Availability unknown

    As an Amazon Associate, Deal.ai earns from qualifying purchases.

    $45.20Checked 14 h ago
    Visit Amazon

Store links may earn us a commission. Some prices via Klarna.

All 3 stores and price history →

Simparica Trio Chewables for Medium Dogs

  • Allivet Pet PharmacyNew

    In stock

    $43.48Free shippingChecked 14 h ago
    Visit Allivet Pet Pharmacy
  • Smartway Pet SuppliesNew

    In stockReturn policy

    $80.00Checked 12 h ago
    Visit Smartway Pet Supplies

Also available at

  • AmazonCheck price at Amazon
  • Tractor Supply CompanyCheck price at Tractor Supply Company

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All 2 stores and price history →

Specs compared

SpecSimparica Trio Chewable Tablet for DogsSimparica Trio Chewables for Medium Dogs
Active ingredientssarolaner, moxidectin, and pyrantelsarolaner, moxidectin, and pyrantel
Tablet colorbrown (reddish brown)brown (reddish brown)
Tablet shapePENTAGON (5 sided) (rounded edges)PENTAGON (5 sided) (rounded edges)
Route of administrationORALORAL
Dosing frequencyonce a monthone chew per month
Flavorliver flavoredTasty liver flavoured chew
AnimalDogDog
Food TypeSupplements—
Sarolaner strength12 mg—
Pyrantel strength50 mg—
Tablet size14mm—
Minimum puppy ageeight weeks old—
Show all 18 specsShow fewer specs
SpecSimparica Trio Chewable Tablet for DogsSimparica Trio Chewables for Medium Dogs
Minimum age—8 weeks of age
Flea kill speed—within 4 to 8 hours after treatment
Flea efficacy duration—35 days
Paralysis tick kill—98.9% of pre-existing paralysis ticks killed wi…
Puppy weight range—1.25-2.5 kg
XL weight range—40.1-60 kg

What reviewers say

Simparica Trio Chewable Tablet for Dogs

Owners generally rate Simparica Trio highly for convenience and broad coverage, and many report their dogs take the chew without fuss. Complaints center on digestive upset in some dogs and on the prescription requirement.

What people mention
  • ConveniencePraisedOwners like replacing separate flea, heartworm and worm products with a single monthly chew.
  • PalatabilityMixedMany dogs take the liver-flavored chew readily, but some owners say their dog refuses it.
  • Digestive upsetCriticisedSome owners report vomiting or loose stools after dosing, usually mild and short-lived.
  • CoveragePraisedOwners value the broad spectrum against fleas, ticks, heartworm and common intestinal worms.

Simparica Trio Chewables for Medium Dogs

  • 4.8 / 539 ratings

Owners rate it highly, with 4.8 out of 5 from 39 ratings. Buyers value getting the genuine Zoetis product sealed and in date, and many switched because it replaces several separate preventives with one monthly chew.

What people mention
  • CoveragePraisedOwners like that one chew covers heartworm, fleas, ticks and intestinal worms.
  • Flea and tick speedPraisedReviewers note fleas die within hours and paralysis ticks are killed quickly.
  • FlavorPraisedThe liver-flavored chew is taken readily by most dogs.

Questions and answers

Are the brown box and the blue pack the same product?
Yes. Both are Simparica Trio chews with sarolaner, moxidectin and pyrantel. They differ only in the weight band they are dosed for, so pick the pack that matches your dog's weight.
Which one should I give a 100 lb dog?
The brown box. It is dosed for dogs from 88.1 to 132 lbs. The blue pack is only for dogs from 22.1 to 44 lbs and would underdose a 100 lb dog.
Which pack suits a Border Collie or Bulldog?
The blue pack, if the dog weighs between 22.1 and 44 lbs. Those breeds typically fall in that range, but weigh your dog first because the band is what matters.
How fast does it kill fleas?
The blue pack starts killing adult fleas within 4 to 8 hours and keeps killing for 35 days. The brown box uses the same ingredients, so expect similar speed.
Is it safe for puppies?
Both are labeled for puppies from 8 weeks old, provided the puppy is within the pack's weight band. Ask your vet before starting any parasite preventive.
Do I need a prescription?
Simparica Trio is a veterinary product, and some sellers ship it without a prescription. Check your local rules and confirm with your vet, especially for heartworm prevention.

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More comparisons

  • Simparica Trio Chewable Tablet for Dogs 88.1-132.0 lbs Brown Box vs Simparica TRIO Chewable
  • Simparica Trio Chewables For Medium Dogs 22.1–44lbs (10.1-20Kg) Blue vs Simparica TRIO Chewable
  • Monthly routineMixedOwners find monthly dosing simple but say a missed month leaves gaps.