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Simparica Trio is a monthly oral parasite preventive for dogs weighing 22.1–44 lbs. One liver-flavored chew combines sarolaner, moxidectin and pyrantel to cover heartworm, fleas, six tick species including paralysis tick, roundworms and hookworms, and it is the combination most often prescribed by US veterinarians. It starts killing fleas within 4 to 8 hours and keeps flea efficacy for about 35 days, so timing between doses matters. Compared with separate monthly products, it replaces a flea/tick chew plus a heartworm preventive plus a dewormer with one dose, which is why owners and vets favor it for medium breeds like Cocker Spaniels, Bulldogs and Border Collies.
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Lowest price we've seen: $39.47 on Nov 15 at Amazon. Tracked across 3 stores since Nov 15.
Owners rate it highly, with 4.8 out of 5 from 39 ratings. Buyers value getting the genuine Zoetis product sealed and in date, and many switched because it replaces several separate preventives with one monthly chew.
Simparica Trio is a monthly chewable parasite preventive for medium dogs weighing 22.1–44 lbs (10.1–20 kg). One chew protects against heartworm disease, fleas, six species of ticks, roundworms and hookworms. It also helps prevent infections that may cause Lyme disease by killing black-legged (deer) ticks.
It combines three active ingredients. Sarolaner kills fleas and ticks. Moxidectin prevents heartworm larvae from developing into adult heartworms. Pyrantel pamoate treats and controls intestinal roundworms and hookworms. The chew is liver flavored.
Fleas start dying within 4 hours, and 100% are killed within 8 hours.
