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Simparica Trio is a once-monthly prescription chew that combines three drugs in one dose: sarolaner for fleas and ticks, moxidectin for heartworm and hookworm, and pyrantel for roundworm and hookworm. It is the first combination product FDA-approved to kill six tick species, including the deer tick that can carry Lyme disease, and studies cited by the maker show fleas dying within 4 hours and full flea kill by 8 hours. The liver-flavored chew suits dogs that take tablets willingly, and most dogs in the maker's study ate it free-choice. Against rivals, it replaces a separate flea/tick product plus a heartworm preventive, though it does not cover tapeworms other than flea tapeworms and needs a veterinarian's prescription.
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Lowest price we've seen: $203.51 on Nov 15 at Tractor Supply Co. Tracked across 6 stores since Nov 15.
Rated 4.6 out of 5 across 628 ratings, owners largely report it is easy to give and effective at keeping fleas and ticks off. Complaints center on stomach upset in some dogs and the need for a vet visit and prescription.
| Weight (lb.) | Sarolaner per Tablet (mg | Moxidectin per Tablet (m | Pyrantel per Tablet (mg) | Number of Tablets Admini |
|---|---|---|---|---|
| 2.8 to 5.5 lb. | 3.0 | 0.06 | 12.5 | 1 |
| 5.5 to 11 lb. | 6.0 | 0.12 | 25 | |
| 11-22 lb. | 12 | 0.24 | 50 | |
| 22-44 lb. | 24 | 0.48 | 100 | |
| 44-88 lb. | 48 | 0.96 | 200 | |
| 88-132 lb. | 72 | 1.44 | 300 |
Simparica Trio is a once-monthly, liver-flavored chewable tablet for dogs. This package is for dogs weighing 2.8 to 5.5 lb and contains 6 treatments. One chew protects against heartworm disease, ticks, fleas, flea tapeworms, roundworms and hookworms.
It kills fleas before they can lay eggs. In studies, it started killing fleas within 4 hours and reached 100% effectiveness in 8 hours. It is the first combination preventative FDA-approved to kill six types of ticks, including the deer tick that may carry Lyme infections.
It can be given with or without food. In a study, 9 out of 10 dogs took it voluntarily. It is approved for puppies as young as eight weeks old who weigh at least the labeled minimum.
