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Frontline
Frontline Plus

Frontline Plus

4.2· 13,774 ratings

Best price now

$41.16at WalmartObserved at 5:11 AM

Compared across 2 stores. Prices are checked against each store and labelled with when.

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Our take on the Frontline Plus

Frontline Plus is a monthly topical flea and tick treatment for dogs and cats, built on fipronil (9.8%) plus S-methoprene (8.8%). The second ingredient is the difference from plain Frontline: it kills flea eggs and larvae, not just adult fleas, which helps break the life cycle. It kills fleas, ticks and chewing lice for 30 days and stays waterproof 24 hours after application. The best new price is $41.16 at Walmart as of November 4, 2026, for the 3-treatment pack.

Best forDog or cat owners fighting an active flea problemMulti-pet households treating every animal monthlyPets that swim or get bathed oftenOwners who prefer a topical over an oral pill
Pros
  • Kills adult fleas plus eggs and larvae, unlike plain Frontline
  • Covers fleas, ticks and chewing lice for a full 30 days
  • Waterproof after 24 hours, so swimming and baths are fine
  • Safe for puppies and kittens from 8 weeks old
  • Single-spot application is quick and easy
Cons
  • Monthly reapplication is easy to forget
  • Does not kill ticks as fast as some oral products
  • Leaves a greasy spot and a strong smell for a day or two
  • Flea resistance to fipronil is reported in some regions
  • Dogs under 5 lb and cats under 1.5 lb need a different product

Frontline Plus prices at every store

  • WalmartNew

    In stock

    $41.16Free shippingObserved at 5:11 AM
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  • Chewy.comNew

    In stock

    $40.98+ $4.95 shippingObserved at 5:11 AM
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Also available at

  • eBayCheck price at eBay
  • AmazonCheck price at Amazon
  • Petco.comCheck price at Petco.com
  • PetSmartCheck price at PetSmart
  • TargetCheck price at Target
  • Tractor Supply CompanyCheck price at Tractor Supply Company

Frontline Plus price history

Lowest price we've seen: $40.98 on Nov 4 at Petco.com. Tracked across 7 stores since Nov 4.

What reviewers say

Rated 4.2 out of 5 from about 13,800 ratings. Most owners say it clears fleas within a day or two and keeps them away with monthly use. Complaints center on the greasy residue, the smell, and fleas returning in areas with resistant populations.

Pros
  • Fast knockdown of fleas
  • Works for a full month
  • Easy single-spot application
  • Safe for young puppies and kittens
Cons
  • Greasy, smelly spot after application
  • Some report fleas surviving in resistant areas
  • Not as fast on ticks as oral chews
  • Price adds up for multi-pet homes

About the Frontline Plus

Keep your dog protected with the #1 name in flea & tick protection*, FRONTLINE. FRONTLINE Plus for Dogs is a fast-acting, long-lasting waterproof flea & tick topical that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease. Break the flea life cycle — FRONTLINE Plus for Dogs is specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea control. Trusted by pet owners for over 20 years**— FRONTLINE Plus for Dogs can be used on puppies as young as eight weeks old, weighing 5 pounds or more, and is easy to apply. Applied to a single point on your pet, the flea and tick control treatment covers your dog's entire body and deposits in the sebaceous glands. These glands act as a reservoir, continuously replenishing the treatment onto your pet, working even if your dog gets wet. Just one dose of FRONTLINE Plus each month protects against fleas & ticks for a full 30 days. FRONTLINE Plus also comes in a formula designed for cats and kittens eight weeks of age and older, 1.5lbs. and over, so you can protect the dogs or cats in your house from fleas and ticks with FRONTLINE Brand Products. Treat all dogs or cats in your household monthly to effectively control fleas and ticks and prevent the establishment of new flea infestations and keep your pets protected year-round. References: *Data on file at Boehringer Ingelheim. **Data showing 20 years of trust in killing fleas and ticks is on file at Boehringer Ingelheim.

Specifications

Active ingredients
fipronil + S-methopreneSource
Fipronil concentration
9.8%Source
S-methoprene concentration
8.8%Source
Dosage form
TopicalSource

Questions and answers

Is Frontline Plus worth it over plain Frontline?
Yes, if fleas keep coming back. Frontline Plus adds S-methoprene, which kills eggs and larvae, so it breaks the life cycle instead of only killing adults. Plain Frontline has fipronil alone.
How long does one dose last?
30 days. Reapply once a month, and treat every dog and cat in the house on the same schedule to keep fleas from re-establishing.
Can I bathe my dog after applying it?
Yes, after 24 hours. The product spreads into the sebaceous glands and keeps replenishing, so it stays effective through baths and swimming once it has dried in.
What size pet is it for?
Puppies from 8 weeks and 5 lb and up, and kittens from 8 weeks and 1.5 lb and up. Pick the dose band that matches your pet's weight; smaller pets need a different formula.
When is the best price?
The 3-pack was $41.16 at Walmart as of November 4, 2026. Multi-pet owners usually save more with the 6-pack, so compare per-treatment cost across both sizes.
Does it kill ticks?
Yes, including ticks that can carry Lyme disease. It works more slowly on ticks than oral products, so check your pet after walks in tall grass.
Where is the Frontline Plus cheapest?
At Walmart, for $41.16, as of our latest check.
What do buyers say about the Frontline Plus?
Rated 4.2 out of 5 from 13,774 ratings.
Where can I buy the Frontline Plus?
8 stores we checked sell it, including Walmart, Chewy.com, eBay, Amazon, Petco.com.

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All Frontline deals and products →
Protection duration
30 daysSource
Application frequency
once a monthSource
Waterproof after
24 hours after applicationSource
Minimum age dogs
8 weeks and olderSource
Minimum age cats
8 weeks and olderSource
Target pests
fleas, flea eggs, flea larvae, chewing lice, & ticksSource
Animal
Cat, Dog
Quantity
3 pack, 6 pack
Count Per Pack
3
color
Purple
size
3 Treatments