How often do I give Trifexis?

Once a month, with a meal. Each chewable protects for about 30 days.

Does Trifexis protect against ticks?

No. It covers fleas, heartworm and intestinal worms only. Add a tick product if your dog is exposed.

What age can puppies start Trifexis?

Puppies 8 weeks and older can take it, dosed by weight.

Why do dogs refuse Trifexis?

The tablets are large and have a strong smell. Many owners hide them in food or crush them.

Is Trifexis a soft chew?

No, it is a firm beef-flavored chewable tablet, which some owners find harder to give than a soft chew.

How does Trifexis differ from a topical flea product?

It is oral, so there is no residue and no greasy coat, and it also prevents heartworm and treats intestinal worms.

Where is the Trifexis Tablets for Dogs cheapest?

At Chewy.com, for $154.09, as of our latest check.

What do buyers say about the Trifexis Tablets for Dogs?

Rated 5 out of 5 from 212 ratings. Buyers like: Keeps dogs flea-free, some for many years; One monthly pill covers fleas, heartworm and intestinal worms; No GI upset or side effects for many dogs. Common complaints: Tablets are huge and hard to give, especially for large dogs; Dogs dislike the taste and smell; owners must hide or crush the pill.

Where can I buy the Trifexis Tablets for Dogs?

5 stores we checked sell it, including PetCareRx, Chewy.com, PetSmart, EntirelyPets Pharmacy, Heartland Veterinary Supply and Pharmacy.

Trifexis Tablets for Dogs Price History: Lowest $154.09 at Chewy.com

What reviewers say

5 / 5212 ratings

Owners report years of flea-free dogs and clean heartworm tests on one monthly pill, and many switched after topicals caused reactions. The main complaints are the tablet size, the taste dogs refuse, and the lack of tick coverage.

What people mention

Flea controlPraisedOwners say it keeps dogs flea-free, some for many years.
Tablet sizeCriticisedThe tablets are large and hard to give, especially to big dogs.
TasteCriticisedMany dogs dislike the taste and smell, so owners hide or crush the pill.
Side effectsMixedMany dogs have no GI upset, but some owners report stomach problems.
Tick coverageCriticisedIt does not protect against ticks, so tick-prone dogs need another product.
ConveniencePraisedOne monthly dose replaces separate flea, heartworm and worm products.

From PetCareRx

Kills adult fleas and prevents flea infestations
Prevents heartworm disease
Treats and controls adult hookworm, roundworm and whipworm infections
One beef-flavored chewable tablet given orally once a month for 30 days of protection
Safe for dogs and puppies 8 weeks and older
Two active ingredients: spinosad and milbemycin oxime

Sizes: 5-10 lbs., 10.1-20 lbs., 20.1-40 lbs., 40.1-60 lbs., 60.1-120 lbs.
Materials: Beef-flavored chewable tablets made with pork-based proteins and hydrolyzed soy; active ingredients spinosad and milbemycin oxime
Sizing: Dosage is based on the dog's weight; pills increase in size with the dog's weight, and reviewers note the tablets are large and hard to give
Care: Store at room temperature (68–77°F or 20–25°C), dry, out of reach of children and animals, in original packaging
Shipping: Free shipping over a minimum order; arrives in 1-3 days on average
Packs: 6-month supply; weight-based sizes from 5-10 lbs. up to 60.1-120 lbs.
In the box: 6-month supply of chewable tablets

About the Trifexis Tablets for Dogs

Trifexis is a monthly chewable tablet for dogs that protects against heartworm, fleas and intestinal parasites. It contains two active ingredients, spinosad and milbemycin oxime. It kills adult fleas and prevents flea infestations, prevents heartworm disease, and treats and controls adult hookworm, roundworm and whipworm infections.

Each dose is one round, brown, beef-flavored chewable tablet given by mouth once a month, with a meal. The tablets are made with pork-based proteins and hydrolyzed soy. Flea killing starts within 30 minutes, and each tablet gives 30 days of protection.

The dose is based on the dog's weight, and the tablets get larger as the weight range increases. The product is for dogs and puppies 8 weeks of age or older. It comes in five sizes.

Active ingredients: Spinosad and milbemycin oxime
Spinosad dose: 13.5 mg/lb (30 mg/kg)
Milbemycin dose: 0.2 mg/lb (0.5 mg/kg)
Form: Beef-flavored chewable tablet, round, brown
Dosing: One tablet once a month, given with a meal
Minimum age: 8 weeks or older
Weight sizes: 5-10 lbs., 10.1-20 lbs., 20.1-40 lbs., 40.1-60 lbs., 60.1-120 lbs.
Storage: Room temperature (68–77°F / 20–25°C), dry, in original packaging, out of reach of children and animals
In the box: 6-month supply of chewable tablets