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Bravecto for Dogs - 12-week dose (Rx) vs NexGard PLUS

Pick Bravecto if you want the fewest doses and the lowest upfront cost: it is one topical dose every 12 weeks and the best new price is $80.99 at Amazon as of November 4, 2026. Pick NexGard PLUS if you want a monthly beef-flavored chew that also covers roundworms and heartworm prevention, at $115.19 at Chewy.com as of November 4, 2026. Bravecto is cheaper per box but covers fleas and ticks only; NexGard PLUS costs more and is dosed monthly.

Today the Bravecto for Dogs - 12-week dose (Rx) costs $34.20 less at its best price.

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Bravecto
Bravecto for Dogs - 12-week dose (Rx)

Bravecto for Dogs - 12-week dose (Rx)

$80.99at AmazonObserved at 5:11 AM
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Choose the Bravecto 12-week dose if you want flea and tick protection from a single topical dose every 12 weeks and want to spend less upfront.

Pros
  • One dose lasts 12 weeks, so four doses a year
  • Lowest best new price of the two: $80.99 at Amazon
  • Kills fleas and ticks for the full 12 weeks
  • No pill to hide in food
Cons

What separates them

Bravecto for Dogs - 12-week dose (Rx)NexGard PLUS
FormTopical liquid between the shoulder bladesBeef-flavored chewable tablet
Dosing intervalEvery 12 weeksEvery month
Pests coveredFleas and ticksFleas, ticks, roundworms, plus heartworm prevention
Minimum age6 months8 weeks
Lone star tick protection8 weeksMonthly coverage while dosed
Water resistanceWater resistant 3 days after applicationWater-resistant and waterproof
Price as of November 4, 2026$80.99 at Amazon$115.19 at Chewy.com

Price history

  • Bravecto for Dogs - 12-week dose (Rx): lowest $80.99 on Nov 4 at Amazon.
  • NexGard PLUS: lowest $115.19 on Nov 4 at Chewy.com.

Prices at every store

Bravecto for Dogs - 12-week dose (Rx)

  • AmazonNew

    Availability unknown

    As an Amazon Associate, Deal.ai earns from qualifying purchases.

    $80.99Observed at 5:11 AM
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Also available at

  • Chewy.comCheck price at Chewy.com
  • DutchCheck price at Dutch
  • FBNCheck price at FBN
Prices and history →

NexGard PLUS

  • Chewy.comNew

    In stock

    $115.19Free shippingObserved at 5:09 AM
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  • PetMart PharmacyNew

    In stock

    $115.20Free shippingObserved at 5:09 AM
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Also available at

  • AmazonCheck price at Amazon

Specs compared

SpecBravecto for Dogs - 12-week dose (Rx)NexGard PLUS
Active ingredientfluralanerMoxidectin, Afoxolaner, Pyrantel
AnimalDog—
Formtopical solution—
Minimum dose11.4 mg/lb (25 mg/kg) body weight—
Fluralaner concentration280 mg—
Dosing intervalevery 12 weeks—
Flea protection duration12 weeks—
Tick protection duration12 weeks—
Lone star tick duration8 weeks—
Minimum age6 months of age and older

What reviewers say

Bravecto for Dogs - 12-week dose (Rx)

Owners generally rate Bravecto topical highly for lasting flea and tick control and the convenience of quarterly dosing. Complaints center on application mess and residue at the application site, and some dogs show temporary skin irritation there.

Pros
  • Long 12-week coverage between doses
  • Effective flea control reported by most owners
  • Easy to apply between the shoulder blades
Cons
  • Greasy residue and mess at the application site
  • Occasional skin irritation or reaction at the spot
  • Cost per dose is high even though doses are infrequent

NexGard PLUS

Owners of NexGard PLUS generally report it is easy to give and effective against fleas and ticks, and they like dropping a separate heartworm pill. Complaints center on cost and the occasional dog that vomits or spits it out.

Pros

Questions and answers

Which is better for a dog that hates pills?
Bravecto. It is a topical liquid applied between the shoulder blades every 12 weeks, so there is no pill to swallow. NexGard PLUS is a chew, which suits dogs that take treats readily.
Does NexGard PLUS cover more parasites than Bravecto?
Yes. NexGard PLUS adds roundworms and heartworm prevention to flea and tick coverage. Bravecto covers fleas and ticks only, so you would need a separate heartworm product.
Which lasts longer between doses?
Bravecto. One dose protects for 12 weeks, including 8 weeks against lone star ticks. NexGard PLUS is given monthly, so protection depends on dosing every 30 days.
Is Bravecto worth the savings over NexGard PLUS?
Bravecto is $80.99 at Amazon and NexGard PLUS is $115.19 at Chewy.com as of November 4, 2026. Bravecto is cheaper per box, but it does not replace a heartworm preventive, so add that cost before comparing.
Can I use either on a young puppy?
NexGard PLUS is labeled for puppies as young as 8 weeks. Bravecto is for dogs 6 months and older, so a young puppy needs the NexGard PLUS or another puppy-safe product.
Can my dog swim after either product?
NexGard PLUS is waterproof, so swimming is fine. Bravecto is water resistant for 3 days after application, so avoid bathing or swimming during that window.

More comparisons

  • Bravecto for Dogs - 12-week dose (Rx) vs Bravecto Chews for Dogs
  • Bravecto Chews for Dogs vs NexGard PLUS
  • Bravecto for Dogs - 12-week dose (Rx) vs Simparica TRIO Chewable Tablets for Dogs
  • Simparica TRIO Chewable Tablets for Dogs vs NexGard PLUS

Buying guides that pick them

  • Best flea treatments for dogs
Topical can leave a greasy spot and needs 3 days before swimming or bathing
  • Not for puppies under 6 months
  • No roundworm or heartworm coverage
  • Lone star tick protection drops to 8 weeks
  • NexGard
    NexGard PLUS

    NexGard PLUS

    $115.19at Chewy.comObserved at 5:09 AM
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    Choose the NexGard PLUS if your dog takes chews easily and you want flea, tick and roundworm coverage plus heartworm prevention in one monthly tablet.

    Pros
    • Covers fleas, ticks and roundworms and prevents heartworm disease
    • Beef-flavored chew most dogs take as a treat
    • Can start at 8 weeks of age
    • Waterproof, so swimming and bathing are not restricted
    Cons
    • Monthly dosing means 12 doses a year
    • Higher price: $115.19 at Chewy.com as of November 4, 2026
    • Not for dogs that refuse chews or have beef sensitivity
    • Prescription required
    Prescription
    Rx required
    Prescription product
    All 2 stores and price history →
    —
    Administration sitebetween the shoulder blades—
    Water resistance3 days after administration—
    Show all 30 specsShow fewer specs
    SpecBravecto for Dogs - 12-week dose (Rx)NexGard PLUS
    Targeted Pests—Fleas, Roundworms, Ticks
    Administration Method—Chewable tablet, Oral
    Life Stage Age—Puppies as young as 8 weeks of age
    Treatment Frequency—Monthly
    Dosage Concentration—75 mg Afoxolaner
    Dosage Duration—Monthly
    Formulation Type—Chewable
    Formulation—Water-Resistant, Waterproof
    Lifecycle Targeted—Adults (fleas)
    Animal Type—Dogs, Puppies
    Suitable For Health Status—MDR1 gene deficient dogs
    Treatment Type—Prevention, Treatment
    Supply Duration—1 month supply
    Supply Amount—6 tablets
    Weight Range—33.1-66 lbs
    Contains—Afoxolaner, Moxidectin, Pyrantel
    Package Type—Box (Purple)
    Scent—Beef-flavored
  • Easy to give as a beef chew
  • Flea and tick control holds up between doses
  • One chew replaces two products
  • Works for puppies and MDR1 dogs
  • Cons
    • Higher price than older NexGard alone
    • Some dogs vomit after dosing
    • Not every dog likes the taste
    • Prescription requirement adds a vet visit