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Simparica Chewables for Dogs vs NexGard PLUS Chewable

Both are monthly beef-flavored chews that kill fleas and ticks, but they are not the same job. Simparica is a single-ingredient sarolaner tablet that does fleas and ticks only, and it starts killing fleas fast. NexGard PLUS adds moxidectin and pyrantel, so it also prevents heartworm disease and treats roundworm infections, and it is labeled for puppies from 8 weeks. Choose Simparica for a straightforward flea-and-tick chew for a dog already covered for heartworm. Choose NexGard PLUS to cover fleas, ticks, heartworm and roundworms in one monthly chew.

  • Choose the Simparica if your dog already gets a separate heartworm preventive and you want a simple monthly flea-and-tick chew that acts quickly.
  • Choose the NexGard PLUS if you want one monthly chew that covers fleas, ticks, heartworm disease and roundworms, or you have a puppy at least 8 weeks old.

Prices

  • Simparica Chewables for Dogs: $69.37 at Chewy.com (last seen Nov 9)
  • NexGard PLUS Chewable: $45.09 at Amazon (checked today)
  • Difference: the NexGard PLUS Chewable is $24.28 cheaper than the Simparica Chewables for Dogs at the latest prices (Nov 9 and Nov 11)
Simparica
Simparica Chewables for Dogs

Simparica Chewables for Dogs

5(3 ratings)
$69.37at Chewy.comChecked Nov 9
See all prices and details
Visit Chewy.com
Pros
  • Kills fleas and ticks for a full month per chew
  • Fast flea kill after dosing
  • Small liver-flavored chew that can be broken into food
  • Simple single-ingredient formula
Cons
  • No heartworm or worm coverage
  • Not for puppies under 6 months
  • Needs a vet prescription
NexGard
NexGard PLUS

NexGard PLUS Chewable

NexGard PLUS

$45.09at AmazonChecked 1 h ago
See all prices and details
Visit Amazon

As an Amazon Associate, Deal.ai earns from qualifying purchases.

Pros
  • Covers fleas, ticks, heartworm and roundworms in one chew
  • Can be given to puppies from 8 weeks
  • Beef flavor most dogs accept
  • Fewer separate products to remember each month
Cons
  • Contains three drugs, so more to check with your vet
  • Not for dogs with a known sensitivity to any ingredient
  • Needs a vet prescription and a heartworm test first

What separates them

Simparica Chewables for DogsNexGard PLUS Chewable
Parasites coveredFleas and ticks onlyFleas, ticks, heartworm disease and roundworms
Active ingredientsSarolaner aloneAfoxolaner, moxidectin and pyrantel
Minimum ageOver 6 months8 weeks
Flea kill speedStarts killing fleas within hours of dosingKills fleas, with afoxolaner acting within hours too
Heartworm preventionNoneYes, via moxidectin
DosingOne chew monthly by weightOne chew monthly by weight
FlavorLiver-flavored chewBeef-flavored chew
PrescriptionRequiredRequired

Price history

$235.59$20.99
Nov 4Nov 11
  • Simparica Chewables for Dogs: lowest $20.99 on Nov 11 at Bandana Rx.
  • NexGard PLUS Chewable: lowest $45.09 on Nov 11 at Amazon.

Prices at every store

Simparica Chewables for Dogs

  • Chewy.comNew

    Availability unknown

    $69.37Checked Nov 9
    Visit Chewy.com
  • Heartland Veterinary Supply and PharmacyNew

    Availability unknown

    $79.24Checked Nov 9
    Visit Heartland Veterinary Supply and Pharmacy
  • VetRxDirect a Pet PharmacyNew

    Availability unknown

    $128.55Checked Nov 9
    Visit VetRxDirect a Pet Pharmacy
  • Koala HealthNew

    Availability unknown

    $128.55Checked Nov 9
    Visit Koala Health

Also available at

  • Allivet Pet PharmacyCheck price at Allivet Pet Pharmacy
  • AmazonCheck price at Amazon
  • Bandana RxCheck price at Bandana Rx
All 7 stores and price history →

NexGard PLUS Chewable

  • Petco.comNew

    In stock

    $45.29Free shippingChecked 11 h ago
    Visit Petco.com
  • Chewy.comNew

    In stock

    $48.99+ $4.95 shippingChecked 11 h ago
    Visit Chewy.com
  • PetSmartNew

    In stock

    $48.99+ $6.99 shippingChecked 11 h ago
    Visit PetSmart
  • AmazonNew

    Availability unknown

    As an Amazon Associate, Deal.ai earns from qualifying purchases.

    $45.09Checked 1 h ago
    Visit Amazon
All 17 stores and price history →

Specs compared

SpecSimparica Chewables for DogsNexGard PLUS Chewable
AnimalDogDog
Active ingredientsarolanerMoxidectin, Afoxolaner, Pyrantel
Food TypeDog ChewSupplements
ColorGreenPurple
No. of Packs (pack)66
Minimum dosage0.91 mg/lb (2 mg/kg)—
Dosing frequencyonce a month—
Minimum ageover 6 months of age—
Tablet strengths5, 10, 20, 40, 80, 120—
Formflavored, chewable tablet—
RouteFOR ORAL USE IN DOGS ONLY—
Flea protection durationone month—
Show all 36 specsShow fewer specs
SpecSimparica Chewables for DogsNexGard PLUS Chewable
Tick protection durationone month—
Tablet shapesquare shaped chewable tablets with rounded edg…—
Onset for fleaswithin 8 hours of attachment—
Targeted Pests—Fleas, Roundworms, Ticks
Administration Method—Chewable tablet, Oral
Life Stage Age—Puppies as young as 8 weeks of age
Treatment Frequency—Monthly
Dosage Concentration—75 mg Afoxolaner
Dosage Duration—Monthly

What reviewers say

Simparica Chewables for Dogs

Owners generally report Simparica works well, with fleas and ticks clearing quickly and few side effects. A minority describe vomiting, lethargy or loose stools after the chew, and some dogs refuse the flavor.

What people mention
  • EfficacyPraisedOwners say fleas and ticks are gone within a day or two of the first dose.
  • TasteMixedMany dogs eat it as a treat, but some owners say their dog refuses the flavor.
  • Stomach upsetCriticisedA minority report vomiting or loose stool after dosing, usually short-lived.
  • ConveniencePraisedOwners like skipping topical application and not worrying about baths or swimming.

NexGard PLUS Chewable

Owners of NexGard PLUS generally report it is easy to give and effective against fleas and ticks, and they like replacing a separate heartworm pill. Complaints center on stomach upset in some dogs and the need for a prescription.

What people mention
  • Ease of dosingPraisedOwners say most dogs take the beef chew without a fight.
  • Flea and tick controlPraisedUsers report fleas and ticks gone and staying gone with monthly use.
  • Stomach upsetCriticisedSome owners report vomiting or diarrhea after the first dose.
  • Heartworm coveragePraisedBuyers like combining heartworm prevention with flea and tick control in one chew.

Questions and answers

Which is better for a dog that already takes a heartworm preventive?
Simparica. It handles fleas and ticks, and your existing heartworm product covers the rest, so you avoid paying for overlapping coverage.
Does NexGard PLUS replace a heartworm preventive?
Yes. The moxidectin in NexGard PLUS prevents heartworm disease, so you do not need a separate monthly heartworm pill. Your vet will usually want a negative heartworm test before starting.
Can I give either to a puppy?
NexGard PLUS is labeled for puppies from 8 weeks. Simparica is only for dogs over 6 months, so a young puppy needs the NexGard product or another puppy-safe option.
Which one kills fleas faster?
Both act within hours of dosing. Simparica is documented to start killing fleas within about 3 hours of administration, and afoxolaner in NexGard PLUS also kills fleas quickly. Neither is a instant fix for an infested home.
Is one worth stepping up to?
Step up to NexGard PLUS if you want heartworm and roundworm coverage in the same chew and do not already use a heartworm preventive. Stay with Simparica if your dog is already covered and tolerates it well.
Do both need a prescription?
Yes. Both are prescription products, so you need a vet's authorization before ordering.

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Buying guides that pick them

  • Best flea treatments for dogs
Formulation Type—Chewable
Formulation—Water-Resistant, Waterproof
Lifecycle Targeted—Adults (fleas)
Animal Type—Dogs, Puppies
Suitable For Health Status—MDR1 gene deficient dogs
Treatment Type—Prevention, Treatment
Supply Duration—1 month supply
Supply Amount—6 tablets
Weight Range—33.1-66 lbs
Contains—Afoxolaner, Moxidectin, Pyrantel
Package Type—Box (Purple)
Scent—Beef-flavored
Age Group—Adult, Puppy
Special Diets—Joints & Mobility
Supplements—Joint & Bone