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Bravecto for Dogs - 12-week dose (Rx) vs Simparica TRIO Chewable Tablets for Dogs

Bravecto is the cheaper, less frequent choice: one topical dose every 12 weeks for $80.99 at Amazon as of November 4, 2026. Simparica TRIO is a monthly liver-flavored chew that also kills hookworms and roundworms and prevents heartworm, at $234.77 at Amazon as of November 4, 2026. Pick Bravecto if you want flea and tick cover only and dosing four times a year. Pick Simparica TRIO if you want one monthly chew that covers fleas, ticks, heartworm and intestinal worms.

Today the Bravecto for Dogs - 12-week dose (Rx) costs $153.78 less at its best price.

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Bravecto
Bravecto for Dogs - 12-week dose (Rx)

Bravecto for Dogs - 12-week dose (Rx)

$80.99at AmazonObserved at 5:11 AM
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Choose the Bravecto if you want flea and tick protection only, dosed every 12 weeks, and you would rather not give a monthly pill.

Pros
  • One dose covers 12 weeks, so four doses a year
  • Lowest price of the two at $80.99 at Amazon as of November 4, 2026
  • Kills fleas and ticks, including 8 weeks against lone star tick
  • No pill to hide in food
Cons
  • No heartworm or intestinal worm coverage
  • Needs a prescription
  • Keep the dog from swimming or bathing for 3 days after each dose
  • Not for puppies under 6 months
Simparica
Simparica TRIO Chewable Tablets for Dogs

Simparica TRIO Chewable Tablets for Dogs

$234.77at AmazonObserved at 5:09 AM
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Choose the Simparica TRIO if you want a single monthly chew that also prevents heartworm and treats roundworms and hookworms.

Pros
  • Covers fleas, ticks, heartworm, roundworms and hookworms in one chew
  • Flea kill within 4 to 8 hours; paralysis tick kill within 24 hours
  • Can start at 8 weeks of age
  • No bathing or swimming restrictions
Cons
  • Monthly dosing, 12 chews a year
  • Costs $234.77 at Amazon as of November 4, 2026, about $154 more than Bravecto
  • Needs a prescription
  • Some dogs refuse or spit out chews

What separates them

Bravecto for Dogs - 12-week dose (Rx)Simparica TRIO Chewable Tablets for Dogs
FormTopical liquid applied between the shoulder bladesLiver-flavored chewable tablet given by mouth
Dosing intervalEvery 12 weeksEvery month
CoverageFleas and ticks onlyFleas, ticks, heartworm, roundworms, hookworms
Minimum age6 months8 weeks
Tick protection length12 weeks for most ticks, 8 weeks for lone star tickMonthly, with paralysis tick kill within 24 hours
Flea kill speedNot stated on the label dataWithin 4 to 8 hours
Water resistanceHold off bathing or swimming for 3 days after applicationOral, so swimming and bathing are not restricted
Price$80.99 at Amazon as of November 4, 2026$234.77 at Amazon as of November 4, 2026

Price history

  • Bravecto for Dogs - 12-week dose (Rx): lowest $80.99 on Nov 4 at Amazon.
  • Simparica TRIO Chewable Tablets for Dogs: lowest $44.63 on Nov 4 at Petco.com.

Prices at every store

Bravecto for Dogs - 12-week dose (Rx)

  • AmazonNew

    Availability unknown

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    $80.99Observed at 5:11 AM
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Also available at

  • Chewy.comCheck price at Chewy.com
  • DutchCheck price at Dutch
  • FBNCheck price at FBN
Prices and history →

Simparica TRIO Chewable Tablets for Dogs

  • Petco.comNew

    In stock

    $44.63Free shippingObserved at 5:09 AM
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  • AmazonNew

    Availability unknown

    As an Amazon Associate, Deal.ai earns from qualifying purchases.

    $234.77Observed at 5:09 AM
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All 2 stores and price history →

Specs compared

SpecBravecto for Dogs - 12-week dose (Rx)Simparica TRIO Chewable Tablets for Dogs
AnimalDogDog
Formtopical solutionflavored, chewable tablet
Minimum age6 months of age and older8 weeks of age and older
Active ingredientfluralaner—
Minimum dose11.4 mg/lb (25 mg/kg) body weight—
Fluralaner concentration280 mg—
Dosing intervalevery 12 weeks—
Flea protection duration12 weeks—
Tick protection duration12 weeks—
Lone star tick duration8 weeks—
Administration sitebetween the shoulder blades—
Water resistance3 days after administration—
Show all 21 specsShow fewer specs
SpecBravecto for Dogs - 12-week dose (Rx)Simparica TRIO Chewable Tablets for Dogs
Dosing frequency—once a month
Sarolaner dosage—0.54 mg/lb (1.2 mg/kg)
Moxidectin dosage—0.011 mg/lb (24 μg/kg)
Pyrantel dosage—2.27 mg/lb (5 mg/kg)
Administration route—FOR ORAL USE IN DOGS ONLY
Flea kill speed—within 4 to 8 hours after treatment
Flea efficacy duration—35 days
Paralysis tick kill—within 24 hours of treatment
Flavor—liver flavoured chew

What reviewers say

Bravecto for Dogs - 12-week dose (Rx)

Owners generally rate Bravecto topical highly for lasting flea and tick control and the convenience of quarterly dosing. Complaints center on application mess and residue at the application site, and some dogs show temporary skin irritation there.

Pros
  • Long 12-week coverage between doses
  • Effective flea control reported by most owners
  • Easy to apply between the shoulder blades
Cons
  • Greasy residue and mess at the application site
  • Occasional skin irritation or reaction at the spot
  • Cost per dose is high even though doses are infrequent

Simparica TRIO Chewable Tablets for Dogs

Owners and vets generally rate Simparica Trio highly for convenience and fast flea control, and many report their dogs take the chew without fuss. The main complaints are cost and occasional stomach upset or refusal of the chew in picky dogs.

Pros
  • One chew replaces several separate products
  • Fast flea and tick knockdown
  • Most dogs accept the liver flavor
  • Simple monthly schedule
Cons
  • Higher cost than buying single-purpose products
  • Some dogs vomit or have loose stool after dosing
  • Picky dogs may spit out the chew
  • No tapeworm coverage

Questions and answers

Which is better for a dog that hates pills?
Bravecto, because it is a topical liquid applied between the shoulder blades instead of a chew. The trade-off is that it covers only fleas and ticks.
Does Bravecto cover heartworm?
No. Bravecto covers fleas and ticks only. If you need heartworm prevention, Simparica TRIO includes it, or your vet can pair Bravecto with a separate heartworm preventive.
Which lasts longer per dose?
Bravecto. One dose protects for 12 weeks against fleas and most ticks, and 8 weeks against the lone star tick. Simparica TRIO is dosed every month.
Is Simparica TRIO worth the extra cost?
It is if you want heartworm and intestinal worm coverage in the same monthly chew. At $234.77 at Amazon as of November 4, 2026, it costs about $154 more than Bravecto at $80.99, so compare that with buying a separate heartworm preventive.
Can I bathe my dog after either product?
After Simparica TRIO, yes, since it is oral. After Bravecto, wait 3 days after application before bathing or swimming.
Which can I start on a young puppy?
Simparica TRIO is labeled for dogs 8 weeks and older. Bravecto is for dogs 6 months and older.

More comparisons

  • Bravecto for Dogs - 12-week dose (Rx) vs NexGard PLUS
  • Bravecto for Dogs - 12-week dose (Rx) vs Bravecto Chews for Dogs
  • Simparica TRIO Chewable Tablets for Dogs vs NexGard PLUS
  • Simparica TRIO Chewable Tablets for Dogs vs Bravecto Chews for Dogs

Buying guides that pick them

  • Best flea treatments for dogs