Simparica TRIO Chewable Tablets for Dogs vs NexGard PLUS
Both are monthly oral chewables covering fleas, ticks, roundworms and heartworm, so the choice comes down to price and tick coverage. NexGard PLUS is far cheaper at the latest prices: $115.19 at Chewy.com versus $234.77 at Amazon as of November 4, 2026. Simparica TRIO adds sarolaner, which kills paralysis ticks within 24 hours, so pick it if you live where paralysis ticks are a risk. Otherwise NexGard PLUS does the same core job for about $120 less per pack.
Today the NexGard PLUS costs $119.58 less at its best price.
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Simparica TRIO Chewable Tablets for Dogs
Choose the Simparica TRIO if you need fast paralysis tick kill and want a liver-flavored chew for a dog 8 weeks or older.
- Kills fleas within 4 to 8 hours
- Kills paralysis ticks within 24 hours
- Flea efficacy lasts 35 days, past the monthly dose
- Liver-flavored chew dogs often take readily
- About $120 more per pack at the latest prices
What separates them
| Simparica TRIO Chewable Tablets for Dogs | NexGard PLUS | |
|---|---|---|
| Latest price | $234.77 at Amazon as of November 4, 2026 | $115.19 at Chewy.com as of November 4, 2026 |
| Active ingredients | Sarolaner, moxidectin, pyrantel | Afoxolaner, moxidectin, pyrantel |
| Paralysis tick kill | Within 24 hours of treatment | Not stated as a paralysis tick claim |
| Flea kill speed | Within 4 to 8 hours | Not stated |
| Flea efficacy duration | 35 days | Monthly dosing |
| Flavor | Liver-flavored chew | Beef-flavored chew |
| Minimum age | 8 weeks | 8 weeks |
| MDR1 gene deficient dogs |
Price history
- Simparica TRIO Chewable Tablets for Dogs: lowest $44.63 on Nov 4 at Petco.com.
- NexGard PLUS: lowest $115.19 on Nov 4 at Chewy.com.
Prices at every store
Simparica TRIO Chewable Tablets for Dogs
- Petco.comNew
In stock
$44.63Free shippingObserved at 5:09 AM - AmazonNew
Availability unknown
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$234.77Observed at 5:09 AM
NexGard PLUS
- Chewy.comNew
In stock
$115.19Free shippingObserved at 5:09 AM - PetMart PharmacyNew
In stock
$115.20Free shippingObserved at 5:09 AM
Also available at
- AmazonCheck price at Amazon
Specs compared
| Spec | Simparica TRIO Chewable Tablets for Dogs | NexGard PLUS |
|---|---|---|
| Animal | Dog | — |
| Minimum age | 8 weeks of age and older | — |
| Dosing frequency | once a month | — |
| Sarolaner dosage | 0.54 mg/lb (1.2 mg/kg) | — |
| Moxidectin dosage | 0.011 mg/lb (24 μg/kg) | — |
| Pyrantel dosage | 2.27 mg/lb (5 mg/kg) | — |
| Administration route | FOR ORAL USE IN DOGS ONLY | — |
| Form | flavored, chewable tablet | — |
| Flea kill speed | within 4 to 8 hours after treatment | — |
| Flea efficacy duration | 35 days |
What reviewers say
Simparica TRIO Chewable Tablets for Dogs
Owners and vets generally rate Simparica Trio highly for convenience and fast flea control, and many report their dogs take the chew without fuss. The main complaints are cost and occasional stomach upset or refusal of the chew in picky dogs.
- One chew replaces several separate products
- Fast flea and tick knockdown
- Most dogs accept the liver flavor
- Simple monthly schedule
- Higher cost than buying single-purpose products
- Some dogs vomit or have loose stool after dosing
- Picky dogs may spit out the chew
- No tapeworm coverage
NexGard PLUS
Owners of NexGard PLUS generally report it is easy to give and effective against fleas and ticks, and they like dropping a separate heartworm pill. Complaints center on cost and the occasional dog that vomits or spits it out.
Questions and answers
- Which is better for paralysis ticks?
- Simparica TRIO. It states paralysis tick kill within 24 hours of treatment. NexGard PLUS does not make that claim.
- Is NexGard PLUS worth the savings?
- Yes for most dogs. It covers fleas, ticks, roundworms and heartworm at $115.19 at Chewy.com versus $234.77 at Amazon as of November 4, 2026.
- Which kills fleas faster?
- Simparica TRIO states flea kill within 4 to 8 hours and flea efficacy for 35 days. NexGard PLUS does not state a flea kill speed.
- Can puppies take either one?
- Both are labeled for puppies 8 weeks and older. Check the weight range on the pack before dosing.
- Which is safer for an MDR1 gene deficient dog?
- NexGard PLUS is listed as suitable for MDR1 gene deficient dogs. Simparica TRIO does not state that, so ask your vet first.
- Do both prevent heartworm?
- Both contain moxidectin, which is used for heartworm prevention. Both are given once a month as a chewable tablet.